Polymorphisms in radio-responsive genes and its association with acute toxicity among head and neck cancer patients

Goutham Hassan Venkatesh, Vadhiraja Bejadi Manjunath, Kamalesh Dattaram Mumbrekar, Hitendra Negi, Donald Jerard Fernandes, Krishna Sharan, Sourjya Banerjee, Satish Rao Bola Sadashiva

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Cellular and molecular approaches are being explored to find a biomarker which can predict the development of radiation induced acute toxicity prior to radiation therapy. SNPs in radiation responsive genes may be considered as an approach to develop tools for finding the inherited basis of clinical radiosensitivity. The current study attempts to screen single nucleotide polymorphisms/deletions in DNA damage response, DNA repair, profibrotic cytokine as well as antioxidant response genes and its predictive potential with the normal tissue adverse reactions from 183 head and neck cancer patients undergoing platinum based chemoradiotherapy or radiotherapy alone. We analysed 22 polymorphisms in 17 genes having functional relevance to radiation response. Radiation therapy induced oral mucositis and skin erythema was considered as end point for clinical radiosensitivity. Direct correlation of heterozygous and mutant alleles with acute reactions as well as haplotype correlation revealed NBN variants to be of predictive significance in analysing oral mucositis prior to radiotherapy. In addition, genetic linkage disequilibrium existed in XRCC1 polymorphisms for >grade 2 oral mucositis and skin reaction indicating the complex inheritance pattern. The current study indicates an association for polymorphism in NBN with normal tissue radiosensitivity and further warrants the replication of such studies in a large set of samples.

Original languageEnglish
Article numbere89079
JournalPLoS One
Volume9
Issue number3
DOIs
Publication statusPublished - 04-03-2014

Fingerprint

Radiotherapy
radiotherapy
acute toxicity
Head and Neck Neoplasms
Polymorphism
Radio
radio
Stomatitis
Toxicity
Radiation Tolerance
Genes
Association reactions
genetic polymorphism
mouth
Radiation
skin (animal)
Single Nucleotide Polymorphism
Chemoradiotherapy
Skin
genes

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Venkatesh, Goutham Hassan ; Manjunath, Vadhiraja Bejadi ; Mumbrekar, Kamalesh Dattaram ; Negi, Hitendra ; Fernandes, Donald Jerard ; Sharan, Krishna ; Banerjee, Sourjya ; Sadashiva, Satish Rao Bola. / Polymorphisms in radio-responsive genes and its association with acute toxicity among head and neck cancer patients. In: PLoS One. 2014 ; Vol. 9, No. 3.
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Polymorphisms in radio-responsive genes and its association with acute toxicity among head and neck cancer patients. / Venkatesh, Goutham Hassan; Manjunath, Vadhiraja Bejadi; Mumbrekar, Kamalesh Dattaram; Negi, Hitendra; Fernandes, Donald Jerard; Sharan, Krishna; Banerjee, Sourjya; Sadashiva, Satish Rao Bola.

In: PLoS One, Vol. 9, No. 3, e89079, 04.03.2014.

Research output: Contribution to journalArticle

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