Polymorphous low-grade adenocarcinoma of maxillary alveolus metastasising to the abdomen: The role of immunomarkers in diagnosis

Aatish Thennavan, Lakshmi Rao, Raghu Radhakrishnan

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Polymorphous low-grade adenocarcinoma (PLGA) originating mostly in the minor salivary glands of the posterior hard and soft palate is characterised by its indolent growth and a slower rate of metastasis. Seldom does the PLGA present an aggressive behaviour and demonstrate distant metastasis, as in the present case where a 73-year-old female patient with a swelling in the maxillary alveolus was diagnosed as PLGA exhibiting high-grade transformation, subsequently metastasizing to the abdomen and lungs. The importance of immunomarkers, c-kit and ki-67 in deciphering the clinical behaviour of this PLGA is highlighted. Distant metastasis to the abdomen has not yet been reported; hence, this case of PLGA emphasises the importance of immunohistochemistry in assessing its aggressiveness and understanding a novel aspect of its pathogenesis.

Original languageEnglish
JournalBMJ Case Reports
Publication statusPublished - 2013


All Science Journal Classification (ASJC) codes

  • Medicine(all)

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