Post-radiation changes in oral tissues - An analysis of cancer irradiation cases

Jay Ashokkumar Pandya, N. Srikant, Karen Boaz, Nidhi Manaktala, Supriya Nikita Kapila, Shanmukha Raviteja Yinti

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: Radiation, commonly employed as neoadjuvant, primary, and adjuvant therapy for head and neck cancer causes numerous epithelial and stromal changes, prominent among which is fibrosis with its early and late consequences. Very little is known about the true nature of the fibrosed tissue and the type of fibers accumulated. Radiotherapy affects the supporting tumor stroma often resulting in a worsening grade of tumor post-radiation. Aim: To study epithelial, neoplastic, stromal, and glandular changes in oral cavity induced by radiation therapy for oral squamous cell carcinoma (OSCC) using special stains. Materials and Methods: The study included 27 samples of recurrent OSCC following completion of radiotherapy (recurrence within an average span of 11 months), and 26 non-irradiated cases of OSCC. Patients with a history of combined radiotherapy and chemotherapy were not included in the study. The epithelial changes assessed included epithelial atrophy, apoptosis, necrosis, dysplasia, and neoplasia. The connective tissue was evaluated for amount of fibrosis, quality of fibers (using picrosirius red staining), fibrinous exudate, necrosis, pattern of invasion, vessel wall thickening, and salivary gland changes. The aforementioned changes were assessed using light and polarizing microscopy and tabulated. Statistical Analysis: Epithelial and connective tissue parameters were compared between the irradiated and non-irradiated cases using chi square and t-tests. Results: Epithelial and connective tissue parameters were found to be increased in irradiated patients. Pattern of invasion by tumor cells varied from strands and cords between the two groups studied. The effect of radiation was seen to reflect on the maturity of fibers and the regularity of their distribution.

Original languageEnglish
Pages (from-to)159-162
Number of pages4
JournalSouth Asian Journal of Cancer
Volume3
Issue number3
DOIs
Publication statusPublished - 01-01-2014

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Radiotherapy
Connective Tissue
Radiation
Squamous Cell Carcinoma
Neoplasms
Fibrosis
Necrosis
Epithelium
Radiation Effects
Exudates and Transudates
Chi-Square Distribution
Head and Neck Neoplasms
Salivary Glands
Atrophy
Mouth
Microscopy
Coloring Agents
Apoptosis
Staining and Labeling
Light

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Pandya, Jay Ashokkumar ; Srikant, N. ; Boaz, Karen ; Manaktala, Nidhi ; Kapila, Supriya Nikita ; Yinti, Shanmukha Raviteja. / Post-radiation changes in oral tissues - An analysis of cancer irradiation cases. In: South Asian Journal of Cancer. 2014 ; Vol. 3, No. 3. pp. 159-162.
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Post-radiation changes in oral tissues - An analysis of cancer irradiation cases. / Pandya, Jay Ashokkumar; Srikant, N.; Boaz, Karen; Manaktala, Nidhi; Kapila, Supriya Nikita; Yinti, Shanmukha Raviteja.

In: South Asian Journal of Cancer, Vol. 3, No. 3, 01.01.2014, p. 159-162.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Post-radiation changes in oral tissues - An analysis of cancer irradiation cases

AU - Pandya, Jay Ashokkumar

AU - Srikant, N.

AU - Boaz, Karen

AU - Manaktala, Nidhi

AU - Kapila, Supriya Nikita

AU - Yinti, Shanmukha Raviteja

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Introduction: Radiation, commonly employed as neoadjuvant, primary, and adjuvant therapy for head and neck cancer causes numerous epithelial and stromal changes, prominent among which is fibrosis with its early and late consequences. Very little is known about the true nature of the fibrosed tissue and the type of fibers accumulated. Radiotherapy affects the supporting tumor stroma often resulting in a worsening grade of tumor post-radiation. Aim: To study epithelial, neoplastic, stromal, and glandular changes in oral cavity induced by radiation therapy for oral squamous cell carcinoma (OSCC) using special stains. Materials and Methods: The study included 27 samples of recurrent OSCC following completion of radiotherapy (recurrence within an average span of 11 months), and 26 non-irradiated cases of OSCC. Patients with a history of combined radiotherapy and chemotherapy were not included in the study. The epithelial changes assessed included epithelial atrophy, apoptosis, necrosis, dysplasia, and neoplasia. The connective tissue was evaluated for amount of fibrosis, quality of fibers (using picrosirius red staining), fibrinous exudate, necrosis, pattern of invasion, vessel wall thickening, and salivary gland changes. The aforementioned changes were assessed using light and polarizing microscopy and tabulated. Statistical Analysis: Epithelial and connective tissue parameters were compared between the irradiated and non-irradiated cases using chi square and t-tests. Results: Epithelial and connective tissue parameters were found to be increased in irradiated patients. Pattern of invasion by tumor cells varied from strands and cords between the two groups studied. The effect of radiation was seen to reflect on the maturity of fibers and the regularity of their distribution.

AB - Introduction: Radiation, commonly employed as neoadjuvant, primary, and adjuvant therapy for head and neck cancer causes numerous epithelial and stromal changes, prominent among which is fibrosis with its early and late consequences. Very little is known about the true nature of the fibrosed tissue and the type of fibers accumulated. Radiotherapy affects the supporting tumor stroma often resulting in a worsening grade of tumor post-radiation. Aim: To study epithelial, neoplastic, stromal, and glandular changes in oral cavity induced by radiation therapy for oral squamous cell carcinoma (OSCC) using special stains. Materials and Methods: The study included 27 samples of recurrent OSCC following completion of radiotherapy (recurrence within an average span of 11 months), and 26 non-irradiated cases of OSCC. Patients with a history of combined radiotherapy and chemotherapy were not included in the study. The epithelial changes assessed included epithelial atrophy, apoptosis, necrosis, dysplasia, and neoplasia. The connective tissue was evaluated for amount of fibrosis, quality of fibers (using picrosirius red staining), fibrinous exudate, necrosis, pattern of invasion, vessel wall thickening, and salivary gland changes. The aforementioned changes were assessed using light and polarizing microscopy and tabulated. Statistical Analysis: Epithelial and connective tissue parameters were compared between the irradiated and non-irradiated cases using chi square and t-tests. Results: Epithelial and connective tissue parameters were found to be increased in irradiated patients. Pattern of invasion by tumor cells varied from strands and cords between the two groups studied. The effect of radiation was seen to reflect on the maturity of fibers and the regularity of their distribution.

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