Potentiation of Hydroxyurea Cytotoxicity by Iron-Chelating Agent in Murine Tumor Models in vitro

K. Satyamoorthy, M. P. Chitnis, S. G. Pradhan

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    The biochemical modulation of tumor cell response to increase the cytotoxicity of Hydroxyurea (HU), directed at the ribonucleotide reductase enzyme, has been studied in in vitro. Mice bearing ascites tumor models such as L1210 leukemia, Sarcoma 180 (S180) and Ehrlich ascites tumor (EAT) were employed in this study. The cytotoxicity of HU alone at various concentrations was dose dependent and showed the following order of sensitivity: L1210 > EAT > S180. The hydrophobic iron-chelating agent 2,2bipyridyl significantly potentiated the antitumor activity of HU in all the murine tumor models studied. In contrast, hydrophilic iron-chelator, Desferal, did not show any cytotoxicity when combined with HU. The present study demonstrated the factors influencing the amelioration of HU cytotoxicity and possible therapeutic use of ironchelating agents alone and with HU for better therapeutic results in clinics.

    Original languageEnglish
    Pages (from-to)173-182
    Number of pages10
    JournalCancer Drug Delivery
    Issue number3
    Publication statusPublished - 1986


    All Science Journal Classification (ASJC) codes

    • Pharmacology
    • Cancer Research

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