Power of BODE index in predicting future exacerbations of COPD: A prospective observational study in Indian population

Chittaluru K. Praveen, Mohan K. Manu, Aswini Kumar Mohapatra, Kalyana C. Pentapati

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Abstract

Background: BODE index is a multidimensional measure of survival in chronic obstructive pulmonary disease (COPD). It is composed of body mass index (B), the degree of airflow obstruction (O), dyspnoea (D), and exercise capacity (E). Studies have shown that BODE index can predict future exacerbations, but similar data in Indian population is unavailable. This study was aimed at evaluating the power of BODE index to predict the frequency of exacerbations of COPD in Indian cohort. Methods: We conducted a prospective observational cohort study that included stable COPD subjects aged above 40 years. We assessed the BODE index at baseline and recorded the number of exacerbations at the end of 12 months. Spearman’s Rho and Poisson regression model were used to correlate the BODE index with the frequency of exacerbations. Results: We analysed 78 COPD patients. A significant correlation was seen between BODE index at baseline and number of exacerbations at 12 months (Spearman’s Rho 0.738). A unit change in BODE index at baseline would have 1.25 times higher number of exacerbations at 12 months (95% CI: 1.17-1.33). Conclusions: BODE index has significant power to predict the frequency of future exacerbations in Indian COPD patients.

Original languageEnglish
Pages (from-to)14-16
Number of pages3
JournalJournal of Association of Physicians of India
Volume67
Issue numberJune
Publication statusPublished - 01-06-2019

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Chronic Obstructive Pulmonary Disease
Observational Studies
Prospective Studies
Population
Dyspnea
Body Mass Index
Cohort Studies
Exercise
Survival

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Power of BODE index in predicting future exacerbations of COPD: A prospective observational study in Indian population",
abstract = "Background: BODE index is a multidimensional measure of survival in chronic obstructive pulmonary disease (COPD). It is composed of body mass index (B), the degree of airflow obstruction (O), dyspnoea (D), and exercise capacity (E). Studies have shown that BODE index can predict future exacerbations, but similar data in Indian population is unavailable. This study was aimed at evaluating the power of BODE index to predict the frequency of exacerbations of COPD in Indian cohort. Methods: We conducted a prospective observational cohort study that included stable COPD subjects aged above 40 years. We assessed the BODE index at baseline and recorded the number of exacerbations at the end of 12 months. Spearman’s Rho and Poisson regression model were used to correlate the BODE index with the frequency of exacerbations. Results: We analysed 78 COPD patients. A significant correlation was seen between BODE index at baseline and number of exacerbations at 12 months (Spearman’s Rho 0.738). A unit change in BODE index at baseline would have 1.25 times higher number of exacerbations at 12 months (95{\%} CI: 1.17-1.33). Conclusions: BODE index has significant power to predict the frequency of future exacerbations in Indian COPD patients.",
author = "Praveen, {Chittaluru K.} and Manu, {Mohan K.} and Mohapatra, {Aswini Kumar} and Pentapati, {Kalyana C.}",
year = "2019",
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TY - JOUR

T1 - Power of BODE index in predicting future exacerbations of COPD

T2 - A prospective observational study in Indian population

AU - Praveen, Chittaluru K.

AU - Manu, Mohan K.

AU - Mohapatra, Aswini Kumar

AU - Pentapati, Kalyana C.

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Background: BODE index is a multidimensional measure of survival in chronic obstructive pulmonary disease (COPD). It is composed of body mass index (B), the degree of airflow obstruction (O), dyspnoea (D), and exercise capacity (E). Studies have shown that BODE index can predict future exacerbations, but similar data in Indian population is unavailable. This study was aimed at evaluating the power of BODE index to predict the frequency of exacerbations of COPD in Indian cohort. Methods: We conducted a prospective observational cohort study that included stable COPD subjects aged above 40 years. We assessed the BODE index at baseline and recorded the number of exacerbations at the end of 12 months. Spearman’s Rho and Poisson regression model were used to correlate the BODE index with the frequency of exacerbations. Results: We analysed 78 COPD patients. A significant correlation was seen between BODE index at baseline and number of exacerbations at 12 months (Spearman’s Rho 0.738). A unit change in BODE index at baseline would have 1.25 times higher number of exacerbations at 12 months (95% CI: 1.17-1.33). Conclusions: BODE index has significant power to predict the frequency of future exacerbations in Indian COPD patients.

AB - Background: BODE index is a multidimensional measure of survival in chronic obstructive pulmonary disease (COPD). It is composed of body mass index (B), the degree of airflow obstruction (O), dyspnoea (D), and exercise capacity (E). Studies have shown that BODE index can predict future exacerbations, but similar data in Indian population is unavailable. This study was aimed at evaluating the power of BODE index to predict the frequency of exacerbations of COPD in Indian cohort. Methods: We conducted a prospective observational cohort study that included stable COPD subjects aged above 40 years. We assessed the BODE index at baseline and recorded the number of exacerbations at the end of 12 months. Spearman’s Rho and Poisson regression model were used to correlate the BODE index with the frequency of exacerbations. Results: We analysed 78 COPD patients. A significant correlation was seen between BODE index at baseline and number of exacerbations at 12 months (Spearman’s Rho 0.738). A unit change in BODE index at baseline would have 1.25 times higher number of exacerbations at 12 months (95% CI: 1.17-1.33). Conclusions: BODE index has significant power to predict the frequency of future exacerbations in Indian COPD patients.

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