PPAR-gamma receptor mediated severe thyroid toxicity in mice

Mridula Sharma, Shivanand Bhushan, A. Nath

    Research output: Contribution to journalArticle

    Abstract

    Pioglitazone a synthetic ligand of peroxisome proliferator activated receptor-Y (PPAR-Y) is currently used in the treatment of type-2 diabetes as an efficient insulin sensitizer. The aim of this study was to establish a Pre-clinical experimental setting to investigate the possible link between prolong use of PPAR-Y agonist and development of thyroid carcinoma in swiss albino mice. Mice were treated with 75 mg/kg body weight of Pioglitazone for four and twelve weeks. As a result, under Light microscopy thyroid carcinoma were observed as four distinct pathways of oncogenesis in form of four lineages after twelve weeks of treatment. Under Electron microscopy after four weeks of treatments had shown only cellular injury and hydropic degenarations but after twelve weeks had shown necrotic oncosis. The level of TSH in Serum were severely elevated after twelve weeks of treatment. Thus, chronic consumption of pioglitazone was not seemed to be safe and had been provided sufficient stimulus to induce carcinogenicity in thyroid gland of mice.

    Original languageEnglish
    Pages (from-to)85-91
    Number of pages7
    JournalJournal of Ecophysiology and Occupational Health
    Volume9
    Issue number1-2
    Publication statusPublished - 01-01-2009

    Fingerprint

    pioglitazone
    diabetes
    PPAR gamma
    electron microscopy
    ligand
    Toxicity
    microscopy
    serum
    Thyroid Gland
    Peroxisome Proliferator-Activated Receptors
    toxicity
    Thyroid Neoplasms
    Insulin
    Medical problems
    Electron microscopy
    Optical microscopy
    Ligands
    Type 2 Diabetes Mellitus
    Microscopy
    Edema

    All Science Journal Classification (ASJC) codes

    • Ecology
    • Pollution
    • Public Health, Environmental and Occupational Health

    Cite this

    Sharma, Mridula ; Bhushan, Shivanand ; Nath, A. / PPAR-gamma receptor mediated severe thyroid toxicity in mice. In: Journal of Ecophysiology and Occupational Health. 2009 ; Vol. 9, No. 1-2. pp. 85-91.
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    PPAR-gamma receptor mediated severe thyroid toxicity in mice. / Sharma, Mridula; Bhushan, Shivanand; Nath, A.

    In: Journal of Ecophysiology and Occupational Health, Vol. 9, No. 1-2, 01.01.2009, p. 85-91.

    Research output: Contribution to journalArticle

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