Pre and post-Treatment effects: Estimation of serum testosterone and lipid peroxidation levels on Moringa olifera extract induced cadmium exposed rats

Pratik Kumar Chatterjee, Vinodini Nithyananda Madom Anantharaya, Rashmi Kaup Shiva, Nayanatara Arun Kumar, Sneha Bhoja Shetty, Suman Veerappa Budihal, Mangalore Ramesh Bhat, Kunal

Research output: Contribution to journalArticle

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Abstract

Background: Cadmium (Cd), is a toxic metal which affects various organs including testis. It produces oxidative stress leading to male infertility. Moringa tree, is a natural plant with a great therapeutic value and hence it is found to be effective both in prevention and treatment of various conditions including reducing toxicity of hazardous materials. The aim of the present study was to examine the effects of Pre-And Post-Treatment with Moringa oliefera leaf extract (MoE) on testis in cadmium exposed rats. Materials and Methods: The present study was conducted at the Department of Physiology, Kasturba Medical College (KMC), Mangalore, Manipal University (MU), Karnataka, India, between (2011-2013). This prospective study consisted a total of 30 rats. These were divided into 5 groups with group I being the control. Data were presented as mean ±SD. student's t test was used as statistical tool, p<0.05 considered statistically significant. Group IV and V were pre-And post-MoE treated groups respectively. Serum testosterone and tissue lipid peroxidation levels were estimated. Results: Treatment with MoE prior and after administration of cadmium, respectively showed an increase significantly in the testosterone levels and a decrease in the tissue lipid peroxidation as compared to the group treated with cadmium. However, the pre-Treatment showed better results in combatting the toxic effects of cadmium. Conclusion: This study shows that Moringa olifera leaf extract altered the testosterone and tissue lipid peroxidation levels. Also, pre-Treatment showed better outcome.

Original languageEnglish
Pages (from-to)846-849
Number of pages4
JournalPharmacognosy Journal
Volume9
Issue number6
DOIs
Publication statusPublished - 01-01-2014

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Moringa
Cadmium
Lipid Peroxidation
Testosterone
Serum
Poisons
Testis
Therapeutics
Hazardous Substances
Male Infertility
India
Oxidative Stress
Metals
Prospective Studies
Students

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

Chatterjee, Pratik Kumar ; Anantharaya, Vinodini Nithyananda Madom ; Shiva, Rashmi Kaup ; Kumar, Nayanatara Arun ; Shetty, Sneha Bhoja ; Budihal, Suman Veerappa ; Bhat, Mangalore Ramesh ; Kunal. / Pre and post-Treatment effects : Estimation of serum testosterone and lipid peroxidation levels on Moringa olifera extract induced cadmium exposed rats. In: Pharmacognosy Journal. 2014 ; Vol. 9, No. 6. pp. 846-849.
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Pre and post-Treatment effects : Estimation of serum testosterone and lipid peroxidation levels on Moringa olifera extract induced cadmium exposed rats. / Chatterjee, Pratik Kumar; Anantharaya, Vinodini Nithyananda Madom; Shiva, Rashmi Kaup; Kumar, Nayanatara Arun; Shetty, Sneha Bhoja; Budihal, Suman Veerappa; Bhat, Mangalore Ramesh; Kunal.

In: Pharmacognosy Journal, Vol. 9, No. 6, 01.01.2014, p. 846-849.

Research output: Contribution to journalArticle

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T2 - Estimation of serum testosterone and lipid peroxidation levels on Moringa olifera extract induced cadmium exposed rats

AU - Chatterjee, Pratik Kumar

AU - Anantharaya, Vinodini Nithyananda Madom

AU - Shiva, Rashmi Kaup

AU - Kumar, Nayanatara Arun

AU - Shetty, Sneha Bhoja

AU - Budihal, Suman Veerappa

AU - Bhat, Mangalore Ramesh

AU - Kunal,

PY - 2014/1/1

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