Pre morbid severity of chronic obstructive pulmonary disease as risk factor for carbon dioxide retention during acute exacerbation of chronic obstructive pulmonary disease

D. S. Harsha, M. Vishnu Sharma, S. Nanjesh Kumar, Alakachaitra Bhat, S. R. Chandrikbabu, Bibin Jose, N. Anupama

Research output: Contribution to journalArticle

Abstract

This was a case control study done in patients admitted with acute exacerbation of chronic obstructive pulmonary disease (COPD). Patients were grouped into categories, depending upon the arterial blood gas analysis. 30patients with carbon dioxide retention Paco2 level >46mmHg which was not a compensation for metabolic alkalosis were classified as cases. 30 patients without carbon dioxide retentionPaco2 level <46mmHg were classified as controls. Pre morbid severity of COPD as per GOLD 2010 was compared between the two groups as risk factor for carbon dioxide retention. The data was entered into the Microsoft Office Excel 2007 and odds ratio was calculated. Patients with severe and very severe COPD showed a risk of having carbon dioxide retention 116 times that of patient with mild and moderate COPD. 50% of cases were in 61-70 years age group. Patients with severe and very severe COPD have a greater risk of carbon dioxide retention during acute exacerbation than patients with mild and moderate COPD. Patients with severe and very severe COPD develop skeletal muscle wasting and skeletal muscle dysfunction, malnutrition, hyperinflation of lungs with poor diaphragm contractility. All these lead to hypoventilation and carbon dioxide retention during acute exacerbation of COPD when ventialtory demand increases.

Original languageEnglish
Pages (from-to)201-206
Number of pages6
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume5
Issue number4
Publication statusPublished - 01-01-2014

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Pulmonary diseases
Carbon Dioxide
Chronic Obstructive Pulmonary Disease
Muscle
Blood gas analysis
Skeletal Muscle
Hypoventilation
Alkalosis
Blood Gas Analysis
Diaphragms
Diaphragm
Malnutrition
Case-Control Studies
Age Groups
Odds Ratio
Lung

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Harsha, D. S. ; Vishnu Sharma, M. ; Nanjesh Kumar, S. ; Bhat, Alakachaitra ; Chandrikbabu, S. R. ; Jose, Bibin ; Anupama, N. / Pre morbid severity of chronic obstructive pulmonary disease as risk factor for carbon dioxide retention during acute exacerbation of chronic obstructive pulmonary disease. In: Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2014 ; Vol. 5, No. 4. pp. 201-206.
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Pre morbid severity of chronic obstructive pulmonary disease as risk factor for carbon dioxide retention during acute exacerbation of chronic obstructive pulmonary disease. / Harsha, D. S.; Vishnu Sharma, M.; Nanjesh Kumar, S.; Bhat, Alakachaitra; Chandrikbabu, S. R.; Jose, Bibin; Anupama, N.

In: Research Journal of Pharmaceutical, Biological and Chemical Sciences, Vol. 5, No. 4, 01.01.2014, p. 201-206.

Research output: Contribution to journalArticle

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