Pre-transplant risk factors for renal allograft dysfunction at one year in Indian patients

Ravindra Prabhu A., G. T. John, V. Shankar, P. P. Thomas, Abi Abraham M., L. Jeyaseelan, C. K. Jacob

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Abstract

Background. Only a few patients with end-stage renal disease in the Indian subcontinent receive optimal treatment. Of these only a minority can afford a second renal transplant. Awareness of modifiable pre-transplant risk factors that influence allograft function is crucial before embarking on the first transplant. There are no reports from the Asian subcontinent describing the pre-transplant risk factors. Methods. We studied the effect of donor age, gender, and relation with the recipient, patient age, gender, HLA matching, native kidney disease and immunosuppression on one-year allograft function using data from 1177 consecutive primary living related donor renal transplants at the Christian Medical College Hospital, Vellore. We performed a univariate followed by a multivariate analysis using a logistic regression model to calculate the odds ratio for the effect of the above factors on two levels of graft function (serum creatinine > 1.4 mg/dl and > 2 mg/dl) at one year. Results. On univariate analysis, older donors, women donors, mother being the donor, men recipients, < 1 HLA antigen match, cyclosporine-based immunosuppression and patient age between 16 and 40 years were associated with serum creatinine levels > 1.4 mg/dl at one year. Multivariate analysis showed that donor-related factors, namely mother as donor, older donors, and a ≤1 HLA antigen match, were risk factors for graft dysfunction (serum creatinine level > 1.4 mg/dl) at one year. Recipient-related risk factors were male patients and those between the age of 16 and 40 years. Conclusion. In patients undergoing living related donor renal transplants from large extended families, a younger haplomatched donor, for instance, a brother, is a better choice than an older haplomatched donor, for instance, the mother, particularly in young male recipients at a higher risk of renal dysfunction.

Original languageEnglish
Pages (from-to)18-21
Number of pages4
JournalNational Medical Journal of India
Volume14
Issue number1
Publication statusPublished - 01-01-2001

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Allografts
Tissue Donors
Transplants
Kidney
Living Donors
Mothers
Creatinine
Multivariate Analysis
Logistic Models
Kidney Diseases
Interpersonal Relations
HLA Antigens
Serum
Immunosuppression
Chronic Kidney Failure
Siblings
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Prabhu A., R., John, G. T., Shankar, V., Thomas, P. P., Abraham M., A., Jeyaseelan, L., & Jacob, C. K. (2001). Pre-transplant risk factors for renal allograft dysfunction at one year in Indian patients. National Medical Journal of India, 14(1), 18-21.
Prabhu A., Ravindra ; John, G. T. ; Shankar, V. ; Thomas, P. P. ; Abraham M., Abi ; Jeyaseelan, L. ; Jacob, C. K. / Pre-transplant risk factors for renal allograft dysfunction at one year in Indian patients. In: National Medical Journal of India. 2001 ; Vol. 14, No. 1. pp. 18-21.
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Prabhu A., R, John, GT, Shankar, V, Thomas, PP, Abraham M., A, Jeyaseelan, L & Jacob, CK 2001, 'Pre-transplant risk factors for renal allograft dysfunction at one year in Indian patients', National Medical Journal of India, vol. 14, no. 1, pp. 18-21.

Pre-transplant risk factors for renal allograft dysfunction at one year in Indian patients. / Prabhu A., Ravindra; John, G. T.; Shankar, V.; Thomas, P. P.; Abraham M., Abi; Jeyaseelan, L.; Jacob, C. K.

In: National Medical Journal of India, Vol. 14, No. 1, 01.01.2001, p. 18-21.

Research output: Contribution to journalArticle

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AU - Shankar, V.

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Prabhu A. R, John GT, Shankar V, Thomas PP, Abraham M. A, Jeyaseelan L et al. Pre-transplant risk factors for renal allograft dysfunction at one year in Indian patients. National Medical Journal of India. 2001 Jan 1;14(1):18-21.