Predictors for incidence of primary open-angle glaucoma in a south Indian population

The Chennai eye disease incidence study

Lingam Vijaya, Asokan Rashima, Manish Panday, Nikhil S. Choudhari, Sathyamangalam Ve Ramesh, Velumuri Lokapavani, Sachi Devi Boddupalli, Govindan T. Sunil, Ronnie George

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective To determine the 6-year incidence of primary open-angle glaucoma (POAG) and its associated predictors. Design Population-based cohort study. Participants A total of 4316 subjects without POAG at baseline who were 40 years of age and older from a south Indian population. Methods Participants were examined at baseline and after a 6-year interval. Detailed ophthalmic examination included applanation tonometry, gonioscopy, pachymetry, optic disc evaluation, and automated perimetry. Glaucoma was defined using the International Society of Geographical and Epidemiological Ophthalmology Classification. Multivariable logistic regression was performed to identify the baseline risk factors that could predict the incident POAG. Main Outcome Measures Six-year incidence of POAG and its associated risk factors. Results In 6 years, incident POAG developed in 129 subjects (2.9%; 95% confidence interval [CI], 2.4-3.4; male-to-female ratio, 65:64). Baseline age was a risk factor. In reference to the group 40 to 49 years of age, the incidence increased from 2.3 (95% CI, 1.4-3.7) for the group 50 to 59 years of age to 3.5 (95% CI, 2.2-5.7) for the group 60 to 69 years of age (P < 0.001). Other baseline risk predictors were urban residence (odds ratio [OR], 1.6; 95% CI, 1.1-2.2; P = 0.01), higher intraocular pressure (IOP; OR, 2.0; 95% CI, 1.5-2.6 per 10 mmHg; P < 0.001), myopia (OR, 1.7; 95%, CI, 1.1-2.5; P < 0.001), and axial length (OR, 1.5; 95% CI, 1.0-2.2 per millimeter; P = 0.03). Thinner corneas with higher IOP at baseline had the highest incidence of POAG. In 80% of the urban population and 100% of the rural population, incident glaucoma was previously undetected. Conclusions A significant proportion of this population demonstrated incident POAG. The baseline risk factors could help in identifying those at highest risk of disease.

Original languageEnglish
Pages (from-to)1370-1376
Number of pages7
JournalOphthalmology
Volume121
Issue number7
DOIs
Publication statusPublished - 01-01-2014

Fingerprint

Eye Diseases
Cohort Studies
Confidence Intervals
Incidence
Population
Odds Ratio
Glaucoma
Gonioscopy
Visual Field Tests
Urban Population
Optic Disk
Myopia
Manometry
Rural Population
Ophthalmology
Primary Open Angle Glaucoma
Intraocular Pressure
Cornea
Logistic Models
Outcome Assessment (Health Care)

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Vijaya, Lingam ; Rashima, Asokan ; Panday, Manish ; Choudhari, Nikhil S. ; Ramesh, Sathyamangalam Ve ; Lokapavani, Velumuri ; Boddupalli, Sachi Devi ; Sunil, Govindan T. ; George, Ronnie. / Predictors for incidence of primary open-angle glaucoma in a south Indian population : The Chennai eye disease incidence study. In: Ophthalmology. 2014 ; Vol. 121, No. 7. pp. 1370-1376.
@article{55da0a19fbb541119e2f8ee60949945e,
title = "Predictors for incidence of primary open-angle glaucoma in a south Indian population: The Chennai eye disease incidence study",
abstract = "Objective To determine the 6-year incidence of primary open-angle glaucoma (POAG) and its associated predictors. Design Population-based cohort study. Participants A total of 4316 subjects without POAG at baseline who were 40 years of age and older from a south Indian population. Methods Participants were examined at baseline and after a 6-year interval. Detailed ophthalmic examination included applanation tonometry, gonioscopy, pachymetry, optic disc evaluation, and automated perimetry. Glaucoma was defined using the International Society of Geographical and Epidemiological Ophthalmology Classification. Multivariable logistic regression was performed to identify the baseline risk factors that could predict the incident POAG. Main Outcome Measures Six-year incidence of POAG and its associated risk factors. Results In 6 years, incident POAG developed in 129 subjects (2.9{\%}; 95{\%} confidence interval [CI], 2.4-3.4; male-to-female ratio, 65:64). Baseline age was a risk factor. In reference to the group 40 to 49 years of age, the incidence increased from 2.3 (95{\%} CI, 1.4-3.7) for the group 50 to 59 years of age to 3.5 (95{\%} CI, 2.2-5.7) for the group 60 to 69 years of age (P < 0.001). Other baseline risk predictors were urban residence (odds ratio [OR], 1.6; 95{\%} CI, 1.1-2.2; P = 0.01), higher intraocular pressure (IOP; OR, 2.0; 95{\%} CI, 1.5-2.6 per 10 mmHg; P < 0.001), myopia (OR, 1.7; 95{\%}, CI, 1.1-2.5; P < 0.001), and axial length (OR, 1.5; 95{\%} CI, 1.0-2.2 per millimeter; P = 0.03). Thinner corneas with higher IOP at baseline had the highest incidence of POAG. In 80{\%} of the urban population and 100{\%} of the rural population, incident glaucoma was previously undetected. Conclusions A significant proportion of this population demonstrated incident POAG. The baseline risk factors could help in identifying those at highest risk of disease.",
author = "Lingam Vijaya and Asokan Rashima and Manish Panday and Choudhari, {Nikhil S.} and Ramesh, {Sathyamangalam Ve} and Velumuri Lokapavani and Boddupalli, {Sachi Devi} and Sunil, {Govindan T.} and Ronnie George",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.ophtha.2014.01.014",
language = "English",
volume = "121",
pages = "1370--1376",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "7",

}

Vijaya, L, Rashima, A, Panday, M, Choudhari, NS, Ramesh, SV, Lokapavani, V, Boddupalli, SD, Sunil, GT & George, R 2014, 'Predictors for incidence of primary open-angle glaucoma in a south Indian population: The Chennai eye disease incidence study', Ophthalmology, vol. 121, no. 7, pp. 1370-1376. https://doi.org/10.1016/j.ophtha.2014.01.014

Predictors for incidence of primary open-angle glaucoma in a south Indian population : The Chennai eye disease incidence study. / Vijaya, Lingam; Rashima, Asokan; Panday, Manish; Choudhari, Nikhil S.; Ramesh, Sathyamangalam Ve; Lokapavani, Velumuri; Boddupalli, Sachi Devi; Sunil, Govindan T.; George, Ronnie.

In: Ophthalmology, Vol. 121, No. 7, 01.01.2014, p. 1370-1376.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Predictors for incidence of primary open-angle glaucoma in a south Indian population

T2 - The Chennai eye disease incidence study

AU - Vijaya, Lingam

AU - Rashima, Asokan

AU - Panday, Manish

AU - Choudhari, Nikhil S.

AU - Ramesh, Sathyamangalam Ve

AU - Lokapavani, Velumuri

AU - Boddupalli, Sachi Devi

AU - Sunil, Govindan T.

AU - George, Ronnie

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objective To determine the 6-year incidence of primary open-angle glaucoma (POAG) and its associated predictors. Design Population-based cohort study. Participants A total of 4316 subjects without POAG at baseline who were 40 years of age and older from a south Indian population. Methods Participants were examined at baseline and after a 6-year interval. Detailed ophthalmic examination included applanation tonometry, gonioscopy, pachymetry, optic disc evaluation, and automated perimetry. Glaucoma was defined using the International Society of Geographical and Epidemiological Ophthalmology Classification. Multivariable logistic regression was performed to identify the baseline risk factors that could predict the incident POAG. Main Outcome Measures Six-year incidence of POAG and its associated risk factors. Results In 6 years, incident POAG developed in 129 subjects (2.9%; 95% confidence interval [CI], 2.4-3.4; male-to-female ratio, 65:64). Baseline age was a risk factor. In reference to the group 40 to 49 years of age, the incidence increased from 2.3 (95% CI, 1.4-3.7) for the group 50 to 59 years of age to 3.5 (95% CI, 2.2-5.7) for the group 60 to 69 years of age (P < 0.001). Other baseline risk predictors were urban residence (odds ratio [OR], 1.6; 95% CI, 1.1-2.2; P = 0.01), higher intraocular pressure (IOP; OR, 2.0; 95% CI, 1.5-2.6 per 10 mmHg; P < 0.001), myopia (OR, 1.7; 95%, CI, 1.1-2.5; P < 0.001), and axial length (OR, 1.5; 95% CI, 1.0-2.2 per millimeter; P = 0.03). Thinner corneas with higher IOP at baseline had the highest incidence of POAG. In 80% of the urban population and 100% of the rural population, incident glaucoma was previously undetected. Conclusions A significant proportion of this population demonstrated incident POAG. The baseline risk factors could help in identifying those at highest risk of disease.

AB - Objective To determine the 6-year incidence of primary open-angle glaucoma (POAG) and its associated predictors. Design Population-based cohort study. Participants A total of 4316 subjects without POAG at baseline who were 40 years of age and older from a south Indian population. Methods Participants were examined at baseline and after a 6-year interval. Detailed ophthalmic examination included applanation tonometry, gonioscopy, pachymetry, optic disc evaluation, and automated perimetry. Glaucoma was defined using the International Society of Geographical and Epidemiological Ophthalmology Classification. Multivariable logistic regression was performed to identify the baseline risk factors that could predict the incident POAG. Main Outcome Measures Six-year incidence of POAG and its associated risk factors. Results In 6 years, incident POAG developed in 129 subjects (2.9%; 95% confidence interval [CI], 2.4-3.4; male-to-female ratio, 65:64). Baseline age was a risk factor. In reference to the group 40 to 49 years of age, the incidence increased from 2.3 (95% CI, 1.4-3.7) for the group 50 to 59 years of age to 3.5 (95% CI, 2.2-5.7) for the group 60 to 69 years of age (P < 0.001). Other baseline risk predictors were urban residence (odds ratio [OR], 1.6; 95% CI, 1.1-2.2; P = 0.01), higher intraocular pressure (IOP; OR, 2.0; 95% CI, 1.5-2.6 per 10 mmHg; P < 0.001), myopia (OR, 1.7; 95%, CI, 1.1-2.5; P < 0.001), and axial length (OR, 1.5; 95% CI, 1.0-2.2 per millimeter; P = 0.03). Thinner corneas with higher IOP at baseline had the highest incidence of POAG. In 80% of the urban population and 100% of the rural population, incident glaucoma was previously undetected. Conclusions A significant proportion of this population demonstrated incident POAG. The baseline risk factors could help in identifying those at highest risk of disease.

UR - http://www.scopus.com/inward/record.url?scp=84903816043&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903816043&partnerID=8YFLogxK

U2 - 10.1016/j.ophtha.2014.01.014

DO - 10.1016/j.ophtha.2014.01.014

M3 - Article

VL - 121

SP - 1370

EP - 1376

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 7

ER -