Predictors of anemia among a cohort of people living with HIV on anti-retroviral therapy in a southern state of India

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Abstract

Anemia is the most prevalent hematological complication among people living with HIV (PLHIV), and its presence can affect the disease progression and mortality. This study aims to ascertain the prevalence of anemia and the factors predicting it in PLHIV on anti-retroviral therapy (ART). Material and methods: In this study, 228 PLHIV who were enrolled for ART in the study period of 3 years from 2012 (February) to 2015 (February) were selected and the data from their records were used for analysis. Factors predicting anemia in PLHIV were assessed using univariate and multivariate logistic regression. Results: The prevalence of anemia in our study was found to be 62.2% (n = 142). The mean hemoglobin among PLHIV was 11.8 g/dl. Age below 45 years, female gender, low body mass index (BMI), smoking, consumption of alcohol, stage 3 or 4 HIV, presence of opportunistic infections, low CD4 count and low total leukocyte count were the factors found to be associated with anemia among PLHIV. On multivariate analysis, low BMI, low CD4 count and low total leukocyte count were the factors significantly predicting anemia among PLHIV. Conclussions: Anemia is a common complication seen among PLHIV. Low CD4 count, low total leukocyte count and undernutrition significantly predict anemia among PLHIV.

Original languageEnglish
Pages (from-to)122-127
Number of pages6
JournalHIV and AIDS Review
Volume17
Issue number2
DOIs
Publication statusPublished - 01-01-2018

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Anemia
India
HIV
CD4 Lymphocyte Count
Leukocyte Count
Therapeutics
Body Mass Index
Opportunistic Infections
Malnutrition
Alcohol Drinking
Disease Progression
Hemoglobins
Multivariate Analysis
Logistic Models
Smoking
Mortality

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Infectious Diseases

Cite this

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title = "Predictors of anemia among a cohort of people living with HIV on anti-retroviral therapy in a southern state of India",
abstract = "Anemia is the most prevalent hematological complication among people living with HIV (PLHIV), and its presence can affect the disease progression and mortality. This study aims to ascertain the prevalence of anemia and the factors predicting it in PLHIV on anti-retroviral therapy (ART). Material and methods: In this study, 228 PLHIV who were enrolled for ART in the study period of 3 years from 2012 (February) to 2015 (February) were selected and the data from their records were used for analysis. Factors predicting anemia in PLHIV were assessed using univariate and multivariate logistic regression. Results: The prevalence of anemia in our study was found to be 62.2{\%} (n = 142). The mean hemoglobin among PLHIV was 11.8 g/dl. Age below 45 years, female gender, low body mass index (BMI), smoking, consumption of alcohol, stage 3 or 4 HIV, presence of opportunistic infections, low CD4 count and low total leukocyte count were the factors found to be associated with anemia among PLHIV. On multivariate analysis, low BMI, low CD4 count and low total leukocyte count were the factors significantly predicting anemia among PLHIV. Conclussions: Anemia is a common complication seen among PLHIV. Low CD4 count, low total leukocyte count and undernutrition significantly predict anemia among PLHIV.",
author = "Shodhan Aithal and Nithin Kumar and Bhaskaran Unnikrishnan and Rekha Thapar and Prasanna Mithra and Vaman Kulkarni and Ramesh Holla and Darshan Bhagwan",
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T1 - Predictors of anemia among a cohort of people living with HIV on anti-retroviral therapy in a southern state of India

AU - Aithal, Shodhan

AU - Kumar, Nithin

AU - Unnikrishnan, Bhaskaran

AU - Thapar, Rekha

AU - Mithra, Prasanna

AU - Kulkarni, Vaman

AU - Holla, Ramesh

AU - Bhagwan, Darshan

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Anemia is the most prevalent hematological complication among people living with HIV (PLHIV), and its presence can affect the disease progression and mortality. This study aims to ascertain the prevalence of anemia and the factors predicting it in PLHIV on anti-retroviral therapy (ART). Material and methods: In this study, 228 PLHIV who were enrolled for ART in the study period of 3 years from 2012 (February) to 2015 (February) were selected and the data from their records were used for analysis. Factors predicting anemia in PLHIV were assessed using univariate and multivariate logistic regression. Results: The prevalence of anemia in our study was found to be 62.2% (n = 142). The mean hemoglobin among PLHIV was 11.8 g/dl. Age below 45 years, female gender, low body mass index (BMI), smoking, consumption of alcohol, stage 3 or 4 HIV, presence of opportunistic infections, low CD4 count and low total leukocyte count were the factors found to be associated with anemia among PLHIV. On multivariate analysis, low BMI, low CD4 count and low total leukocyte count were the factors significantly predicting anemia among PLHIV. Conclussions: Anemia is a common complication seen among PLHIV. Low CD4 count, low total leukocyte count and undernutrition significantly predict anemia among PLHIV.

AB - Anemia is the most prevalent hematological complication among people living with HIV (PLHIV), and its presence can affect the disease progression and mortality. This study aims to ascertain the prevalence of anemia and the factors predicting it in PLHIV on anti-retroviral therapy (ART). Material and methods: In this study, 228 PLHIV who were enrolled for ART in the study period of 3 years from 2012 (February) to 2015 (February) were selected and the data from their records were used for analysis. Factors predicting anemia in PLHIV were assessed using univariate and multivariate logistic regression. Results: The prevalence of anemia in our study was found to be 62.2% (n = 142). The mean hemoglobin among PLHIV was 11.8 g/dl. Age below 45 years, female gender, low body mass index (BMI), smoking, consumption of alcohol, stage 3 or 4 HIV, presence of opportunistic infections, low CD4 count and low total leukocyte count were the factors found to be associated with anemia among PLHIV. On multivariate analysis, low BMI, low CD4 count and low total leukocyte count were the factors significantly predicting anemia among PLHIV. Conclussions: Anemia is a common complication seen among PLHIV. Low CD4 count, low total leukocyte count and undernutrition significantly predict anemia among PLHIV.

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