Predictors of malignancy in pancreatic head mass

a prospective study.

Arjun Sivarman, Ashok Muthukrishnan, Nagendra Boopathy Senguttvan, Suraj Anil Suchak, Umashankkar Kannan

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The objective of the study was to identify the predictive factors for malignancy in pancreatic head mass as a primary outcome and assess the value of CA 19-9 as a diagnostic tool for malignancy as a secondary outcome. A prospective study of patients presented with pancreatic head mass was conducted in a tertiary care referral hospital, Manipal, India from May 2006 to November 2008. The study population was divided into malignant and benign groups based on the final histopathology report. A univariate and multivariate analysis of potential predictive factors for malignancy were conducted. A total of 102 patients with pancreatic head mass were included in the study after fulfilling the inclusion/exclusion criteria. 78 were malignant and 24 were benign. There was significant weight loss (p<0.001) and high mean bilirubin levels (p=0.002) in the malignant group. Mean CA 19-9 was significantly higher in the malignant group (290.7 vs. 30.3 U/ml; p<0.001). Sensitivity and specificity of CA 19-9 for detecting malignancy in pancreatic head mass at a cut off of 35 U/ml was 86% and 79% respectively. CA 19-9 positivity rate was higher with increasing cut off values of 100, 200 and 300 U/ml but such high levels occurred in fewer patients. All the non-jaundiced patients (100%) with raised CA 19-9 levels were found to be malignant compared to 86% malignancy in jaundiced patients. In multivariate analysis, a combination of weight loss>10% of body weight and bilirubin>3 mg/dl and CA 19-9>35 U/ml had specificity and positive predictive value of 100% for predicting malignancy in pancreatic head mass. The presence of weight loss and jaundice and raised CA 19-9 levels together in a patient with pancreatic head mass can be predictive of malignancy. A very high CA 19-9 level can be an indicator of malignancy in a pancreatic head mass. A raised CA 19-9 level may be more predictive of malignancy in non-jaundiced patients than in jaundiced patients.

Original languageEnglish
Number of pages1
JournalThe Pan African medical journal
Volume9
Publication statusPublished - 01-12-2011
Externally publishedYes

Fingerprint

Prospective Studies
Neoplasms
Jaundice
Weight Loss
Tertiary Healthcare
Bilirubin
Tertiary Care Centers
India
Multivariate Analysis
Body Weight
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Sivarman, A., Muthukrishnan, A., Boopathy Senguttvan, N., Anil Suchak, S., & Kannan, U. (2011). Predictors of malignancy in pancreatic head mass: a prospective study. The Pan African medical journal, 9.
Sivarman, Arjun ; Muthukrishnan, Ashok ; Boopathy Senguttvan, Nagendra ; Anil Suchak, Suraj ; Kannan, Umashankkar. / Predictors of malignancy in pancreatic head mass : a prospective study. In: The Pan African medical journal. 2011 ; Vol. 9.
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Sivarman, A, Muthukrishnan, A, Boopathy Senguttvan, N, Anil Suchak, S & Kannan, U 2011, 'Predictors of malignancy in pancreatic head mass: a prospective study.', The Pan African medical journal, vol. 9.

Predictors of malignancy in pancreatic head mass : a prospective study. / Sivarman, Arjun; Muthukrishnan, Ashok; Boopathy Senguttvan, Nagendra; Anil Suchak, Suraj; Kannan, Umashankkar.

In: The Pan African medical journal, Vol. 9, 01.12.2011.

Research output: Contribution to journalArticle

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N2 - The objective of the study was to identify the predictive factors for malignancy in pancreatic head mass as a primary outcome and assess the value of CA 19-9 as a diagnostic tool for malignancy as a secondary outcome. A prospective study of patients presented with pancreatic head mass was conducted in a tertiary care referral hospital, Manipal, India from May 2006 to November 2008. The study population was divided into malignant and benign groups based on the final histopathology report. A univariate and multivariate analysis of potential predictive factors for malignancy were conducted. A total of 102 patients with pancreatic head mass were included in the study after fulfilling the inclusion/exclusion criteria. 78 were malignant and 24 were benign. There was significant weight loss (p<0.001) and high mean bilirubin levels (p=0.002) in the malignant group. Mean CA 19-9 was significantly higher in the malignant group (290.7 vs. 30.3 U/ml; p<0.001). Sensitivity and specificity of CA 19-9 for detecting malignancy in pancreatic head mass at a cut off of 35 U/ml was 86% and 79% respectively. CA 19-9 positivity rate was higher with increasing cut off values of 100, 200 and 300 U/ml but such high levels occurred in fewer patients. All the non-jaundiced patients (100%) with raised CA 19-9 levels were found to be malignant compared to 86% malignancy in jaundiced patients. In multivariate analysis, a combination of weight loss>10% of body weight and bilirubin>3 mg/dl and CA 19-9>35 U/ml had specificity and positive predictive value of 100% for predicting malignancy in pancreatic head mass. The presence of weight loss and jaundice and raised CA 19-9 levels together in a patient with pancreatic head mass can be predictive of malignancy. A very high CA 19-9 level can be an indicator of malignancy in a pancreatic head mass. A raised CA 19-9 level may be more predictive of malignancy in non-jaundiced patients than in jaundiced patients.

AB - The objective of the study was to identify the predictive factors for malignancy in pancreatic head mass as a primary outcome and assess the value of CA 19-9 as a diagnostic tool for malignancy as a secondary outcome. A prospective study of patients presented with pancreatic head mass was conducted in a tertiary care referral hospital, Manipal, India from May 2006 to November 2008. The study population was divided into malignant and benign groups based on the final histopathology report. A univariate and multivariate analysis of potential predictive factors for malignancy were conducted. A total of 102 patients with pancreatic head mass were included in the study after fulfilling the inclusion/exclusion criteria. 78 were malignant and 24 were benign. There was significant weight loss (p<0.001) and high mean bilirubin levels (p=0.002) in the malignant group. Mean CA 19-9 was significantly higher in the malignant group (290.7 vs. 30.3 U/ml; p<0.001). Sensitivity and specificity of CA 19-9 for detecting malignancy in pancreatic head mass at a cut off of 35 U/ml was 86% and 79% respectively. CA 19-9 positivity rate was higher with increasing cut off values of 100, 200 and 300 U/ml but such high levels occurred in fewer patients. All the non-jaundiced patients (100%) with raised CA 19-9 levels were found to be malignant compared to 86% malignancy in jaundiced patients. In multivariate analysis, a combination of weight loss>10% of body weight and bilirubin>3 mg/dl and CA 19-9>35 U/ml had specificity and positive predictive value of 100% for predicting malignancy in pancreatic head mass. The presence of weight loss and jaundice and raised CA 19-9 levels together in a patient with pancreatic head mass can be predictive of malignancy. A very high CA 19-9 level can be an indicator of malignancy in a pancreatic head mass. A raised CA 19-9 level may be more predictive of malignancy in non-jaundiced patients than in jaundiced patients.

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M3 - Article

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Sivarman A, Muthukrishnan A, Boopathy Senguttvan N, Anil Suchak S, Kannan U. Predictors of malignancy in pancreatic head mass: a prospective study. The Pan African medical journal. 2011 Dec 1;9.