Predictors of severity of scrub typhus in the Indian subcontinent

Suman Suryanarayana Karanth, Krishna Chaitanya Marupudi, Varun Pal Reddy Sama, Anurag Gupta, Kirthinath Ballal, Asha Kamath

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To identify the factors for predicting severity in scrub typhus which is an acute febrile illness caused by Orientia tsutsugamushi. Methods: A prospective study of 220 patients with scrub typhus was conducted at Kasturba hospital during May 2012 to April 2013, out of which 116 patients were in the severe disease group and 104 in the non-severe group. Results: Using univariate analysis, the presence of the following factors, namely age>40 years, haemoglobin<12 g/L, white blood cell count>10 000 cells/mm3, platelet<150 000 cells/mm3, albumin<3.5 g/dL and the absence of eschar were correlated with severe disease. However, on multivariate analysis, haemoglobin<12 g/dL (OR=2; P=0.037; CI=1.04-3.82); white blood cell count>10 000 cells/mm3 (OR=3; P=0.001; CI=1.5-5.8), platelet<150 000 cell/mm3 (OR=6.2; P<0.001; CI=3.1-12.4) and absence of eschar (OR=0.4; P=0.01; CI=0.2-0.8) were found to be predictors of severity. Conclusions: We conclude haemoglobin<12 g/dL, WBC count>10 000/mm3, platelet<150 000/mm3 and absence of eschar to be independent predictors of severity of illness in scrub typhus.

Original languageEnglish
Pages (from-to)S674-S678
JournalAsian Pacific Journal of Tropical Disease
Volume4
Issue numberS2
DOIs
Publication statusPublished - 01-02-2014

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Predictors of severity of scrub typhus in the Indian subcontinent'. Together they form a unique fingerprint.

  • Cite this