Predominance and influence of vitamin D deficiency on glycemic and lipid indices in type 2 diabetes patients

A case-control study

Y. Durgarao, Poornima A. Manjrekar, Prabha Adhikari, S. Arun, M. Chakrapani, M. S. Rukmini

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Abstract

Objective: To investigate the existence of vitamin D deficiency (VDD) among Type 2 diabetes, nondiabetes individuals and its effect on both glycemic and lipid profiles. Methods: A case-control study was conducted on 200 subjects of both genders (100 Type 2 diabetes and 100 nondiabetes individuals) aged 40-60 years. Fasting serum 25-hydroxycholecalciferol (25(OH) D) levels, fasting blood sugar (FBS), hemoglobin A1c (HbA1c), lipid profile including total cholesterol (TC), triglycerides (TGs), high density lipoprotein (HDL), low density lipoprotein (LDL), TC/HDL, and very LDL were estimated. Atherogenic index of plasma (AIP) was calculated. Group comparisons were done by one-way analysis of variance followed by post-hoc Tukey’s test and Student’s independent t-test. Chi-square test was performed for categorical variables. Correlation was done by Pearson’s analysis. p<0.05 was considered significant. Results: The average serum 25(OH) D levels were significantly (p<0.001) low in diabetes group. The prevalence of VDD and the percentage of insufficient and sufficient categories was significantly (p<0.001) high and low, respectively, in diabetes group. In the deficient category, diabetes group had severe VDD with significantly low-HDL and elevated TGs and there was an insignificant but negative association between serum vitamin D levels, FBS, HbA1c, TC, TG, LDL, TC/HDL, and AIP among diabetes patients. Conclusion: The occurrence of severe VDD coupled with the independent association of the same with the glycemic and lipid profiles in Type 2 diabetes may further add to the aggravation of complications.

Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalAsian Journal of Pharmaceutical and Clinical Research
Volume10
Issue number4
DOIs
Publication statusPublished - 01-04-2017

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Glycemic Index
Vitamin D Deficiency
Type 2 Diabetes Mellitus
Case-Control Studies
HDL Lipoproteins
Lipids
Fasting
Triglycerides
LDL Cholesterol
Blood Glucose
Hemoglobins
Serum
Calcifediol
VLDL Lipoproteins
Chi-Square Distribution
LDL Lipoproteins
Vitamin D
HDL Cholesterol
Analysis of Variance
Cholesterol

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

Cite this

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title = "Predominance and influence of vitamin D deficiency on glycemic and lipid indices in type 2 diabetes patients: A case-control study",
abstract = "Objective: To investigate the existence of vitamin D deficiency (VDD) among Type 2 diabetes, nondiabetes individuals and its effect on both glycemic and lipid profiles. Methods: A case-control study was conducted on 200 subjects of both genders (100 Type 2 diabetes and 100 nondiabetes individuals) aged 40-60 years. Fasting serum 25-hydroxycholecalciferol (25(OH) D) levels, fasting blood sugar (FBS), hemoglobin A1c (HbA1c), lipid profile including total cholesterol (TC), triglycerides (TGs), high density lipoprotein (HDL), low density lipoprotein (LDL), TC/HDL, and very LDL were estimated. Atherogenic index of plasma (AIP) was calculated. Group comparisons were done by one-way analysis of variance followed by post-hoc Tukey’s test and Student’s independent t-test. Chi-square test was performed for categorical variables. Correlation was done by Pearson’s analysis. p<0.05 was considered significant. Results: The average serum 25(OH) D levels were significantly (p<0.001) low in diabetes group. The prevalence of VDD and the percentage of insufficient and sufficient categories was significantly (p<0.001) high and low, respectively, in diabetes group. In the deficient category, diabetes group had severe VDD with significantly low-HDL and elevated TGs and there was an insignificant but negative association between serum vitamin D levels, FBS, HbA1c, TC, TG, LDL, TC/HDL, and AIP among diabetes patients. Conclusion: The occurrence of severe VDD coupled with the independent association of the same with the glycemic and lipid profiles in Type 2 diabetes may further add to the aggravation of complications.",
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TY - JOUR

T1 - Predominance and influence of vitamin D deficiency on glycemic and lipid indices in type 2 diabetes patients

T2 - A case-control study

AU - Durgarao, Y.

AU - Manjrekar, Poornima A.

AU - Adhikari, Prabha

AU - Arun, S.

AU - Chakrapani, M.

AU - Rukmini, M. S.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Objective: To investigate the existence of vitamin D deficiency (VDD) among Type 2 diabetes, nondiabetes individuals and its effect on both glycemic and lipid profiles. Methods: A case-control study was conducted on 200 subjects of both genders (100 Type 2 diabetes and 100 nondiabetes individuals) aged 40-60 years. Fasting serum 25-hydroxycholecalciferol (25(OH) D) levels, fasting blood sugar (FBS), hemoglobin A1c (HbA1c), lipid profile including total cholesterol (TC), triglycerides (TGs), high density lipoprotein (HDL), low density lipoprotein (LDL), TC/HDL, and very LDL were estimated. Atherogenic index of plasma (AIP) was calculated. Group comparisons were done by one-way analysis of variance followed by post-hoc Tukey’s test and Student’s independent t-test. Chi-square test was performed for categorical variables. Correlation was done by Pearson’s analysis. p<0.05 was considered significant. Results: The average serum 25(OH) D levels were significantly (p<0.001) low in diabetes group. The prevalence of VDD and the percentage of insufficient and sufficient categories was significantly (p<0.001) high and low, respectively, in diabetes group. In the deficient category, diabetes group had severe VDD with significantly low-HDL and elevated TGs and there was an insignificant but negative association between serum vitamin D levels, FBS, HbA1c, TC, TG, LDL, TC/HDL, and AIP among diabetes patients. Conclusion: The occurrence of severe VDD coupled with the independent association of the same with the glycemic and lipid profiles in Type 2 diabetes may further add to the aggravation of complications.

AB - Objective: To investigate the existence of vitamin D deficiency (VDD) among Type 2 diabetes, nondiabetes individuals and its effect on both glycemic and lipid profiles. Methods: A case-control study was conducted on 200 subjects of both genders (100 Type 2 diabetes and 100 nondiabetes individuals) aged 40-60 years. Fasting serum 25-hydroxycholecalciferol (25(OH) D) levels, fasting blood sugar (FBS), hemoglobin A1c (HbA1c), lipid profile including total cholesterol (TC), triglycerides (TGs), high density lipoprotein (HDL), low density lipoprotein (LDL), TC/HDL, and very LDL were estimated. Atherogenic index of plasma (AIP) was calculated. Group comparisons were done by one-way analysis of variance followed by post-hoc Tukey’s test and Student’s independent t-test. Chi-square test was performed for categorical variables. Correlation was done by Pearson’s analysis. p<0.05 was considered significant. Results: The average serum 25(OH) D levels were significantly (p<0.001) low in diabetes group. The prevalence of VDD and the percentage of insufficient and sufficient categories was significantly (p<0.001) high and low, respectively, in diabetes group. In the deficient category, diabetes group had severe VDD with significantly low-HDL and elevated TGs and there was an insignificant but negative association between serum vitamin D levels, FBS, HbA1c, TC, TG, LDL, TC/HDL, and AIP among diabetes patients. Conclusion: The occurrence of severe VDD coupled with the independent association of the same with the glycemic and lipid profiles in Type 2 diabetes may further add to the aggravation of complications.

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U2 - 10.22159/ajpcr.2017.v10i4.16437

DO - 10.22159/ajpcr.2017.v10i4.16437

M3 - Article

VL - 10

SP - 177

EP - 180

JO - Asian Journal of Pharmaceutical and Clinical Research

JF - Asian Journal of Pharmaceutical and Clinical Research

SN - 0974-2441

IS - 4

ER -