Abstract
Objective: To investigate the existence of vitamin D deficiency (VDD) among Type 2 diabetes, nondiabetes individuals and its effect on both glycemic and lipid profiles. Methods: A case-control study was conducted on 200 subjects of both genders (100 Type 2 diabetes and 100 nondiabetes individuals) aged 40-60 years. Fasting serum 25-hydroxycholecalciferol (25(OH) D) levels, fasting blood sugar (FBS), hemoglobin A1c (HbA1c), lipid profile including total cholesterol (TC), triglycerides (TGs), high density lipoprotein (HDL), low density lipoprotein (LDL), TC/HDL, and very LDL were estimated. Atherogenic index of plasma (AIP) was calculated. Group comparisons were done by one-way analysis of variance followed by post-hoc Tukey’s test and Student’s independent t-test. Chi-square test was performed for categorical variables. Correlation was done by Pearson’s analysis. p<0.05 was considered significant. Results: The average serum 25(OH) D levels were significantly (p<0.001) low in diabetes group. The prevalence of VDD and the percentage of insufficient and sufficient categories was significantly (p<0.001) high and low, respectively, in diabetes group. In the deficient category, diabetes group had severe VDD with significantly low-HDL and elevated TGs and there was an insignificant but negative association between serum vitamin D levels, FBS, HbA1c, TC, TG, LDL, TC/HDL, and AIP among diabetes patients. Conclusion: The occurrence of severe VDD coupled with the independent association of the same with the glycemic and lipid profiles in Type 2 diabetes may further add to the aggravation of complications.
| Original language | English |
|---|---|
| Pages (from-to) | 177-180 |
| Number of pages | 4 |
| Journal | Asian Journal of Pharmaceutical and Clinical Research |
| Volume | 10 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 01-04-2017 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmaceutical Science
- Pharmacology (medical)
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Predominance and influence of vitamin D deficiency on glycemic and lipid indices in type 2 diabetes patients : A case-control study. / Durgarao, Y.; Manjrekar, Poornima A.; Adhikari, Prabha; Arun, S.; Chakrapani, M.; Rukmini, M. S.
In: Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, No. 4, 01.04.2017, p. 177-180.Research output: Contribution to journal › Article
TY - JOUR
T1 - Predominance and influence of vitamin D deficiency on glycemic and lipid indices in type 2 diabetes patients
T2 - A case-control study
AU - Durgarao, Y.
AU - Manjrekar, Poornima A.
AU - Adhikari, Prabha
AU - Arun, S.
AU - Chakrapani, M.
AU - Rukmini, M. S.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Objective: To investigate the existence of vitamin D deficiency (VDD) among Type 2 diabetes, nondiabetes individuals and its effect on both glycemic and lipid profiles. Methods: A case-control study was conducted on 200 subjects of both genders (100 Type 2 diabetes and 100 nondiabetes individuals) aged 40-60 years. Fasting serum 25-hydroxycholecalciferol (25(OH) D) levels, fasting blood sugar (FBS), hemoglobin A1c (HbA1c), lipid profile including total cholesterol (TC), triglycerides (TGs), high density lipoprotein (HDL), low density lipoprotein (LDL), TC/HDL, and very LDL were estimated. Atherogenic index of plasma (AIP) was calculated. Group comparisons were done by one-way analysis of variance followed by post-hoc Tukey’s test and Student’s independent t-test. Chi-square test was performed for categorical variables. Correlation was done by Pearson’s analysis. p<0.05 was considered significant. Results: The average serum 25(OH) D levels were significantly (p<0.001) low in diabetes group. The prevalence of VDD and the percentage of insufficient and sufficient categories was significantly (p<0.001) high and low, respectively, in diabetes group. In the deficient category, diabetes group had severe VDD with significantly low-HDL and elevated TGs and there was an insignificant but negative association between serum vitamin D levels, FBS, HbA1c, TC, TG, LDL, TC/HDL, and AIP among diabetes patients. Conclusion: The occurrence of severe VDD coupled with the independent association of the same with the glycemic and lipid profiles in Type 2 diabetes may further add to the aggravation of complications.
AB - Objective: To investigate the existence of vitamin D deficiency (VDD) among Type 2 diabetes, nondiabetes individuals and its effect on both glycemic and lipid profiles. Methods: A case-control study was conducted on 200 subjects of both genders (100 Type 2 diabetes and 100 nondiabetes individuals) aged 40-60 years. Fasting serum 25-hydroxycholecalciferol (25(OH) D) levels, fasting blood sugar (FBS), hemoglobin A1c (HbA1c), lipid profile including total cholesterol (TC), triglycerides (TGs), high density lipoprotein (HDL), low density lipoprotein (LDL), TC/HDL, and very LDL were estimated. Atherogenic index of plasma (AIP) was calculated. Group comparisons were done by one-way analysis of variance followed by post-hoc Tukey’s test and Student’s independent t-test. Chi-square test was performed for categorical variables. Correlation was done by Pearson’s analysis. p<0.05 was considered significant. Results: The average serum 25(OH) D levels were significantly (p<0.001) low in diabetes group. The prevalence of VDD and the percentage of insufficient and sufficient categories was significantly (p<0.001) high and low, respectively, in diabetes group. In the deficient category, diabetes group had severe VDD with significantly low-HDL and elevated TGs and there was an insignificant but negative association between serum vitamin D levels, FBS, HbA1c, TC, TG, LDL, TC/HDL, and AIP among diabetes patients. Conclusion: The occurrence of severe VDD coupled with the independent association of the same with the glycemic and lipid profiles in Type 2 diabetes may further add to the aggravation of complications.
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U2 - 10.22159/ajpcr.2017.v10i4.16437
DO - 10.22159/ajpcr.2017.v10i4.16437
M3 - Article
VL - 10
SP - 177
EP - 180
JO - Asian Journal of Pharmaceutical and Clinical Research
JF - Asian Journal of Pharmaceutical and Clinical Research
SN - 0974-2441
IS - 4
ER -