Pregnancy-associated asymptomatic bacteriuria and drug resistance

S. Khan, Rashmi, P. Singh, Z. Siddiqui, M. Ansari

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Abstract Objectives In developing countries, bacteriuria is associated with significant maternal and foetal risks. Rapid emergence of antibiotic resistance warrants continuous monitoring of the susceptibility patterns of bacterial isolates. In this study, we report our findings regarding the drug resistance patterns of bacteria isolates from pregnant women with urinary tract infections (UTI). Methods This study included 1358 pregnant women attending the antenatal clinic at the Department of Obstetrics and Gynecology between July 2013 and August 2014. Urine specimens were processed for isolation and identification of bacterial species following standard microbiological methods. The disc diffusion test was used to determine the antimicrobial resistance patterns of the recovered isolates at the Central Laboratory of Microbiology of Nepalgunj Medical College, Nepal. Results Three hundred and seventeen isolates were positive for significant bacteriuria. E. coli, K. pneumonia, P. aeruginosa, E. faecalis, S. aureus, P. mirabilis, CoNS, and P. vulgaris accounted for 61.5%, 17%, 7.5%, 5.3%, 2.8%, 2.5%, 1.8%, and 1.2% of bacterial isolates, respectively. Resistance to erythromycin (58.6%), co-trimoxazole (57.4%) and ciprofloxacin (50.1%) was observed. Among the 317 positive isolates, 203 (64%) were from women in the 21-30-year-old age group, and the rate of bacteriuria in this group was statistically significantly more than those for the other age groups (P < 0.05). Conclusions Bacteriuria is frequent among pregnant women, which generates a need for routine urine culture screening. In this study, E. coli was the most predominant bacterial species identified followed by K. pneumonia. Furthermore, women in the 21-30-year-old group were at a higher risk of UTI. Erythromycin, co-trimoxazole and ciprofloxacin should not be empirically used as first-line drugs in the treatment of UTIs. Continuous local monitoring of resistance patterns is necessary to determine the appropriate empirical antimicrobial therapy.

Original languageEnglish
Article number167
Pages (from-to)340-345
Number of pages6
JournalJournal of Taibah University Medical Sciences
Volume10
Issue number3
DOIs
Publication statusPublished - 01-09-2015
Externally publishedYes

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Bacteriuria
Drug Resistance
Pregnant Women
Pregnancy
Sulfamethoxazole Drug Combination Trimethoprim
Erythromycin
Ciprofloxacin
Urinary Tract Infections
Pneumonia
Age Groups
Mirabilis
Urine
Escherichia coli
Nepal
Hospital Obstetrics and Gynecology Department
Microbial Drug Resistance
Microbiology
Gynecology
Developing Countries
Mothers

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Khan, S. ; Rashmi ; Singh, P. ; Siddiqui, Z. ; Ansari, M. / Pregnancy-associated asymptomatic bacteriuria and drug resistance. In: Journal of Taibah University Medical Sciences. 2015 ; Vol. 10, No. 3. pp. 340-345.
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Pregnancy-associated asymptomatic bacteriuria and drug resistance. / Khan, S.; Rashmi; Singh, P.; Siddiqui, Z.; Ansari, M.

In: Journal of Taibah University Medical Sciences, Vol. 10, No. 3, 167, 01.09.2015, p. 340-345.

Research output: Contribution to journalArticle

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AB - Abstract Objectives In developing countries, bacteriuria is associated with significant maternal and foetal risks. Rapid emergence of antibiotic resistance warrants continuous monitoring of the susceptibility patterns of bacterial isolates. In this study, we report our findings regarding the drug resistance patterns of bacteria isolates from pregnant women with urinary tract infections (UTI). Methods This study included 1358 pregnant women attending the antenatal clinic at the Department of Obstetrics and Gynecology between July 2013 and August 2014. Urine specimens were processed for isolation and identification of bacterial species following standard microbiological methods. The disc diffusion test was used to determine the antimicrobial resistance patterns of the recovered isolates at the Central Laboratory of Microbiology of Nepalgunj Medical College, Nepal. Results Three hundred and seventeen isolates were positive for significant bacteriuria. E. coli, K. pneumonia, P. aeruginosa, E. faecalis, S. aureus, P. mirabilis, CoNS, and P. vulgaris accounted for 61.5%, 17%, 7.5%, 5.3%, 2.8%, 2.5%, 1.8%, and 1.2% of bacterial isolates, respectively. Resistance to erythromycin (58.6%), co-trimoxazole (57.4%) and ciprofloxacin (50.1%) was observed. Among the 317 positive isolates, 203 (64%) were from women in the 21-30-year-old age group, and the rate of bacteriuria in this group was statistically significantly more than those for the other age groups (P < 0.05). Conclusions Bacteriuria is frequent among pregnant women, which generates a need for routine urine culture screening. In this study, E. coli was the most predominant bacterial species identified followed by K. pneumonia. Furthermore, women in the 21-30-year-old group were at a higher risk of UTI. Erythromycin, co-trimoxazole and ciprofloxacin should not be empirically used as first-line drugs in the treatment of UTIs. Continuous local monitoring of resistance patterns is necessary to determine the appropriate empirical antimicrobial therapy.

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