Abstract

One of the landmarks in clinical genetics is prenatal diagnosis of genetic disorders. The recent advances in the field have made it possible to diagnose the genetic conditions in the embryos before implantation in a setting of in vitro fertilization. Polymerase chain reaction and fluorescence in situ hybridization are the two common techniques employed on a single or two cells obtained via embryo biopsy. The couple who seek in vitro fertilization may screen their embryos for aneuploidy and the couple at risk for a monogenic disorder but averse to abortion of the affected fetuses after prenatal diagnosis, are likely to be the best candidates to undergo this procedure. This article reviews the technique, indications, benefits, and limitations of pre-implantation genetic testing in clinical practice.

Original languageEnglish
Pages (from-to)317-320
Number of pages4
JournalJournal of Postgraduate Medicine
Volume56
Issue number4
DOIs
Publication statusPublished - 10-2010

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Preimplantation Diagnosis
Inborn Genetic Diseases
Fertilization in Vitro
Prenatal Diagnosis
Embryonic Structures
Genetic Testing
Aneuploidy
Fluorescence In Situ Hybridization
Fetus
Biopsy
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "One of the landmarks in clinical genetics is prenatal diagnosis of genetic disorders. The recent advances in the field have made it possible to diagnose the genetic conditions in the embryos before implantation in a setting of in vitro fertilization. Polymerase chain reaction and fluorescence in situ hybridization are the two common techniques employed on a single or two cells obtained via embryo biopsy. The couple who seek in vitro fertilization may screen their embryos for aneuploidy and the couple at risk for a monogenic disorder but averse to abortion of the affected fetuses after prenatal diagnosis, are likely to be the best candidates to undergo this procedure. This article reviews the technique, indications, benefits, and limitations of pre-implantation genetic testing in clinical practice.",
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Preimplantation diagnosis of genetic diseases. / Adiga, S. K.; Kalthur, G.; Kumar, Pratap; Girisha, K. M.

In: Journal of Postgraduate Medicine, Vol. 56, No. 4, 10.2010, p. 317-320.

Research output: Contribution to journalReview article

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