Preliminary aphrodisiac activity of hybanthus enneaspermus in rats

V.B. Narayanswamy, M. Manjunatha Setty, S. Malini, A. Shirwaikar

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Orally administered ethanol (300 mg/kg) and aqueous (300 mg/kg) extracts of Hybanthus enneaspermus (L) F. Muell were evaluated for its aphrodisiac activity in sexually inactive male rats both in a single dose regimen and in a chronic regimen as a daily dose for 28 days. Mount and intromission latency and number of mounts, intromissions and ejaculations were the parameters used for assessing sexual arousal and performance. Following a single dose administration, the aqueous extract produced a decrease in the mounting and intromission latency, with an increase in the ejaculatory and intromission frequency. In the chronic model, both the alcohol and aqueous extracts increased the number of mounts, ejaculations and intromissions with decrease in the mounting and intromission latency. Treatment with aqueous extract also elevated the testosterone levels in sexually inactive male rats. The findings suggest that H. ennaespermus may exert aphrodisiac activity in sexually inactive male rats.
Original languageEnglish
Pages (from-to)152-161
Number of pages10
JournalPharmacologyonline
Volume1
Publication statusPublished - 2007

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Violaceae
Aphrodisiacs
Ejaculation
Arousal
Testosterone
Ethanol
Alcohols

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Narayanswamy, V. B., Manjunatha Setty, M., Malini, S., & Shirwaikar, A. (2007). Preliminary aphrodisiac activity of hybanthus enneaspermus in rats. Pharmacologyonline, 1, 152-161.
Narayanswamy, V.B. ; Manjunatha Setty, M. ; Malini, S. ; Shirwaikar, A. / Preliminary aphrodisiac activity of hybanthus enneaspermus in rats. In: Pharmacologyonline. 2007 ; Vol. 1. pp. 152-161.
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abstract = "Orally administered ethanol (300 mg/kg) and aqueous (300 mg/kg) extracts of Hybanthus enneaspermus (L) F. Muell were evaluated for its aphrodisiac activity in sexually inactive male rats both in a single dose regimen and in a chronic regimen as a daily dose for 28 days. Mount and intromission latency and number of mounts, intromissions and ejaculations were the parameters used for assessing sexual arousal and performance. Following a single dose administration, the aqueous extract produced a decrease in the mounting and intromission latency, with an increase in the ejaculatory and intromission frequency. In the chronic model, both the alcohol and aqueous extracts increased the number of mounts, ejaculations and intromissions with decrease in the mounting and intromission latency. Treatment with aqueous extract also elevated the testosterone levels in sexually inactive male rats. The findings suggest that H. ennaespermus may exert aphrodisiac activity in sexually inactive male rats.",
author = "V.B. Narayanswamy and {Manjunatha Setty}, M. and S. Malini and A. Shirwaikar",
note = "Cited By :4 Export Date: 10 November 2017 Correspondence Address: Shirwaikar, A.; Dept. of Pharmacognosy, College of Pharmaceutical Sciences, Manipal - 576 119 Karnataka, India; email: annie.shirwaikar@cops.manipal.edu Chemicals/CAS: alcohol, 64-17-5; levodopa, 59-92-7; testosterone, 58-22-0 References: Singh, N.P., (1988) Flora of Eastern, 1, pp. 141-142. , Karnataka, 1st ed, Mittal Publications, New Delhi, pp; Chopra, R.N., Nayar, S.L., Chopra, I.C., (1956) Glossary of Indian medicinal plants, p. 136. , Council of Industrial and Scientific Research, New Delhi, pp; Yoganarasimhan, S.N., Medicinal Plants of India-Tamilnadu (2000) Regional Research, 2, p. 276. , Centre, Bangalore, pp; Kirthikar, R., Basu, B.D., (1991) Indian medicinal plants, 2, pp. 1361-1363. , 2nd ed, Periodical Express Book Agency, New Delhi, pp; Rajakuruna, N., Harris, C.S., Towers, G.H.N., Antimicrobial activity of plants collected from Serpentine outcrops in Sri Lanka (2002) Pharm. Biol, 40, pp. 235-244; Weniger, B., Lagnika, L., Vonthron-Senecheau, C., Adjobimey, T., Gbenou, J., Moudachirou, Brun, M., Anton, R., Sanni, A., 2004. J. Ethnopharmacol., 90, pp. 279-284; Majumder, P.L., Basu, A., Mal, D., Chemical constituents of Hybanthus enneaspermus (1979) Ind. J. Chem, 17 B, pp. 297-298; Prakash, E., Sha Valli Khan, P.S., Sairam Reddy, P., Rao, K.R., Regeneration of plants from seed derived callus of Hybanthus enneaspermus (L) Muell. A rare ethno botanical herb (1999) Plant Cell Rep, 18, pp. 873-878; Retnam, K.R., De Britto, A.J., Phytochemical analysis of a medicinal plant Hybanthus enneaspermus (L) F. Muell (2003) J. Econ. Taxon. Bot, 27 (PART 3), pp. 701-706; Turner, M.A., (1965) Screening methods in Pharmacology, p. 26. , Academic press, New York, p; Narayanasamy, V.B., Dinesh Kumar, C., Manjunath Setty, M., Shirwaikar, A., (2006) Natural Product Sciences, 12 (2), pp. 104-108; Vedavathi, S., Mrudhula, V., Sudhakar, A., 1997. Tribal Medicines of Chittor (Dist.) A.P. India, Herbal Folklore Research Center, Thirupathi, pp. 86; Ghosh, M.N., (1984) Fundamentals of Experimental Pharmacology, p. 153. , Scientific book agency, Calcutta, pp; Venkataraman, B.V., Joseph, T., Effect of L-dopa on copulatory behavior in rats (1979) Ind. J. Pharm. Sci, 11, pp. 119-125; Burses, J.O., Buresova, J.P., Huston, (1983) Techniques and Basic Experiment for the study of Brain and Behavior, pp. 117-120. , New York, Elsevier Science Publishers B.V. Amsterdam, pp; Daniel B.1987, Pharmacological analysis of male rat sexual behavior, Neurosci.And Biobehave.Rev. 11:365-369; Masters, W.H., Johnson, V.E., (1966) Human Sexual Response, Boston Little, pp. 3-8. , Brown and Company, Boston, pp",
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Narayanswamy, VB, Manjunatha Setty, M, Malini, S & Shirwaikar, A 2007, 'Preliminary aphrodisiac activity of hybanthus enneaspermus in rats', Pharmacologyonline, vol. 1, pp. 152-161.

Preliminary aphrodisiac activity of hybanthus enneaspermus in rats. / Narayanswamy, V.B.; Manjunatha Setty, M.; Malini, S.; Shirwaikar, A.

In: Pharmacologyonline, Vol. 1, 2007, p. 152-161.

Research output: Contribution to journalArticle

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AU - Manjunatha Setty, M.

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