Prenatal diagnosis of intracranial tumors and the difficulties in prognostication: A report of three cases

Akhila Vasudeva, Sapna V. Amin, Rajagopal Kadavigere, Katta M. Girisha, Lavanya Rai

Research output: Contribution to journalArticle

Abstract

Prenatal diagnosis of intracranial tumors generally implies a poor prognosis. We present three such cases, where prognostication was difficult. We attempted to correlate our prenatal counseling with postnatal follow-up/postabortal diagnosis. In the first case, tumor was diagnosed at 37 weeks. Ultrasound and fetal/neonatal MRI suggested a malignant intraventricular tumor. Anticipating guarded prognosis, parents refused neurosurgical intervention. At 1 year, child has normal neurodevelopment. Further magnetic resonance imagings (MRIs) show tumor shrinkage, pointing to a benign tumor. In case two, a choroid plexus tumor was diagnosed at midtrimester anomaly scan. Since it was difficult to rule out a malignant tumor, pregnancy was terminated. However, MRI, autopsy, and histopathology confirmed a choroid plexus papilloma, which is known to have good prognosis. In case three, prenatal MRI showed features of neurological involvement in tuberous sclerosis. However child has no neurological manifestations at 1 year of age. Hence, prognostication of prenatally diagnosed brain tumors remains a challenge.

Original languageEnglish
Pages (from-to)88-91
Number of pages4
JournalInternational Journal of Infertility and Fetal Medicine
Volume6
Issue number2
DOIs
Publication statusPublished - 01-05-2015

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Prenatal Diagnosis
Magnetic Resonance Imaging
Neoplasms
Choroid Plexus Neoplasms
Choroid Plexus Papilloma
Tuberous Sclerosis
Second Pregnancy Trimester
Neurologic Manifestations
Brain Neoplasms
Counseling
Autopsy
Parents
Pregnancy

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine

Cite this

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abstract = "Prenatal diagnosis of intracranial tumors generally implies a poor prognosis. We present three such cases, where prognostication was difficult. We attempted to correlate our prenatal counseling with postnatal follow-up/postabortal diagnosis. In the first case, tumor was diagnosed at 37 weeks. Ultrasound and fetal/neonatal MRI suggested a malignant intraventricular tumor. Anticipating guarded prognosis, parents refused neurosurgical intervention. At 1 year, child has normal neurodevelopment. Further magnetic resonance imagings (MRIs) show tumor shrinkage, pointing to a benign tumor. In case two, a choroid plexus tumor was diagnosed at midtrimester anomaly scan. Since it was difficult to rule out a malignant tumor, pregnancy was terminated. However, MRI, autopsy, and histopathology confirmed a choroid plexus papilloma, which is known to have good prognosis. In case three, prenatal MRI showed features of neurological involvement in tuberous sclerosis. However child has no neurological manifestations at 1 year of age. Hence, prognostication of prenatally diagnosed brain tumors remains a challenge.",
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Prenatal diagnosis of intracranial tumors and the difficulties in prognostication : A report of three cases. / Vasudeva, Akhila; Amin, Sapna V.; Kadavigere, Rajagopal; Girisha, Katta M.; Rai, Lavanya.

In: International Journal of Infertility and Fetal Medicine, Vol. 6, No. 2, 01.05.2015, p. 88-91.

Research output: Contribution to journalArticle

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