Prenatal inflammation induced alterations in spatial learning and memory abilities in adult offspring

Mitigated by physical exercise and environmental enrichment

Thangarajan Rajesh, Ramesh Rao Tantradi, Kiranmai S. Rai, Sivakumar Gopalakrishnan, M. G. Ramesh Babu, Murali Adiga, R. Huban Thomas, Pugazandhi Bhaktavatchalam

Research output: Contribution to journalArticle

Abstract

Prenatal inflammation results in chronic cognitive deficits, including learning and memory impairments in offspring. This study investigated the effects of treadmill exercise followed by environmental enrichment in mitigating the learning and memory impairments in young adult rats that were prenatally exposed to lipopolysaccharide induced inflammation. Pregnant Wistar dams were injected intraperitoneally either saline (control group; 0.5ml; n=6) or LPS group (n=18) (0.5mg/Kg) on alternate days from embryonic day 14 till delivery. After delivery, pups were divided into following groups: (1) Control, (2) LPS, (3) LPS-exercise, (4) LPS-environmental enrichment and (5) LPS-exercise-environmental enrichment. Group 3, 4 and 5 were subjected either to the treadmill exercise or environmental enrichment or both respectively, on postnatal days 15 to 60 followed by an assessment of spatial abilities by Morris water maze test. The young adult rats exposed to prenatal inflammation and subjected to treadmill exercise followed by environmental enrichment displayed significant shorter latency to reach the target quadrant. Also, they spent longer duration in the target quadrant in probe trial compared to the age- matched groups subjected either to exercise or environmental enrichment and LPS group. The exercise and enriched environment during the adolescent period could be an alternative strategy to mitigate cognitive deficits in an individual who were exposed to prenatal inflammation.

Original languageEnglish
Pages (from-to)1681-1688
Number of pages8
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume7
Issue number6
Publication statusPublished - 01-11-2016

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Exercise equipment
Aptitude
Adult Children
Exercise
Inflammation
Data storage equipment
Rats
Dams
Lipopolysaccharides
Young Adult
Learning
Water
Control Groups
Spatial Learning
Spatial Memory
Research Design
Age Groups

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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title = "Prenatal inflammation induced alterations in spatial learning and memory abilities in adult offspring: Mitigated by physical exercise and environmental enrichment",
abstract = "Prenatal inflammation results in chronic cognitive deficits, including learning and memory impairments in offspring. This study investigated the effects of treadmill exercise followed by environmental enrichment in mitigating the learning and memory impairments in young adult rats that were prenatally exposed to lipopolysaccharide induced inflammation. Pregnant Wistar dams were injected intraperitoneally either saline (control group; 0.5ml; n=6) or LPS group (n=18) (0.5mg/Kg) on alternate days from embryonic day 14 till delivery. After delivery, pups were divided into following groups: (1) Control, (2) LPS, (3) LPS-exercise, (4) LPS-environmental enrichment and (5) LPS-exercise-environmental enrichment. Group 3, 4 and 5 were subjected either to the treadmill exercise or environmental enrichment or both respectively, on postnatal days 15 to 60 followed by an assessment of spatial abilities by Morris water maze test. The young adult rats exposed to prenatal inflammation and subjected to treadmill exercise followed by environmental enrichment displayed significant shorter latency to reach the target quadrant. Also, they spent longer duration in the target quadrant in probe trial compared to the age- matched groups subjected either to exercise or environmental enrichment and LPS group. The exercise and enriched environment during the adolescent period could be an alternative strategy to mitigate cognitive deficits in an individual who were exposed to prenatal inflammation.",
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Prenatal inflammation induced alterations in spatial learning and memory abilities in adult offspring : Mitigated by physical exercise and environmental enrichment. / Rajesh, Thangarajan; Tantradi, Ramesh Rao; Rai, Kiranmai S.; Gopalakrishnan, Sivakumar; Ramesh Babu, M. G.; Adiga, Murali; Huban Thomas, R.; Bhaktavatchalam, Pugazandhi.

In: Research Journal of Pharmaceutical, Biological and Chemical Sciences, Vol. 7, No. 6, 01.11.2016, p. 1681-1688.

Research output: Contribution to journalArticle

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AU - Rajesh, Thangarajan

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