Preparation and characterization of novel tamarind gum-based hydrogels for antimicrobial drug delivery applications

Vivek Sharma, Pratyush Patnaik, K. Senthilguru, Suraj K. Nayak, Irshaan Syed, Vinay K. Singh, Preetam Sarkar, Goutam Thakur, Kunal Pal

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Abstract

Tamarind gum (TG) polysaccharide has shown great potential in food and pharmaceutical applications due to their viscosity-modulating properties. In this study, TG hydrogels of varied concentrations were developed by physical gelation method. The prepared hydrogels were characterized by microscopy, XRD, FTIR, mechanical, electrical and drug release studies. Microscopic studies showed formation of globular structures throughout the matrix. XRD and FTIR studies suggested an increase in the associative interactions when the TG content was increased, which in turn resulted in the alteration in the mechanical properties. An increase in the intrinsic ionic conductivity was predicted from the electrical studies. This increase in intrinsic ionic conductivity modulated the release of the drug from the hydrogels. The drug was released in its active form. In gist, it can be concluded that the physical hydrogels prepared using TG may be explored as matrices for drug delivery applications.

Original languageEnglish
Pages (from-to)2101-2113
Number of pages13
JournalChemical Papers
Volume72
Issue number8
DOIs
Publication statusPublished - 01-08-2018

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering
  • Materials Chemistry

Cite this

Sharma, V., Patnaik, P., Senthilguru, K., Nayak, S. K., Syed, I., Singh, V. K., ... Pal, K. (2018). Preparation and characterization of novel tamarind gum-based hydrogels for antimicrobial drug delivery applications. Chemical Papers, 72(8), 2101-2113. https://doi.org/10.1007/s11696-018-0414-x