Abstract
Implantable methotrexate films using poly(D,L-lactic acid) and poly(L-lactic acid) (PLA) of different molecular weights were prepared. The in vitro drug release was dependent on the drug loading and molecular weight of the PLA. By blending these polymers in different ratios, the drug release could be controlled and modified. The antitumor efficacy in Sarcoma-180 tumor-bearing mice revealed that the implantable film was more efficacious than subcutaneous injection of plain methotrexate.
| Original language | English |
|---|---|
| Pages (from-to) | 101-106 |
| Number of pages | 6 |
| Journal | Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents |
| Volume | 4 |
| Issue number | 2 |
| Publication status | Published - 04-1997 |
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All Science Journal Classification (ASJC) codes
- Pharmaceutical Science
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Preparation, characterization, and antitumor efficacy of biodegradable poly(lactic acid) methotrexate implantable films. / Singh, U. V.; Pandey, S.; Umadevi, P.; Udupa, N.
In: Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents, Vol. 4, No. 2, 04.1997, p. 101-106.Research output: Contribution to journal › Article
TY - JOUR
T1 - Preparation, characterization, and antitumor efficacy of biodegradable poly(lactic acid) methotrexate implantable films
AU - Singh, U. V.
AU - Pandey, S.
AU - Umadevi, P.
AU - Udupa, N.
PY - 1997/4
Y1 - 1997/4
N2 - Implantable methotrexate films using poly(D,L-lactic acid) and poly(L-lactic acid) (PLA) of different molecular weights were prepared. The in vitro drug release was dependent on the drug loading and molecular weight of the PLA. By blending these polymers in different ratios, the drug release could be controlled and modified. The antitumor efficacy in Sarcoma-180 tumor-bearing mice revealed that the implantable film was more efficacious than subcutaneous injection of plain methotrexate.
AB - Implantable methotrexate films using poly(D,L-lactic acid) and poly(L-lactic acid) (PLA) of different molecular weights were prepared. The in vitro drug release was dependent on the drug loading and molecular weight of the PLA. By blending these polymers in different ratios, the drug release could be controlled and modified. The antitumor efficacy in Sarcoma-180 tumor-bearing mice revealed that the implantable film was more efficacious than subcutaneous injection of plain methotrexate.
UR - http://www.scopus.com/inward/record.url?scp=0030958449&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030958449&partnerID=8YFLogxK
M3 - Article
VL - 4
SP - 101
EP - 106
JO - Drug Delivery
JF - Drug Delivery
SN - 1071-7544
IS - 2
ER -