Preparation, characterization, and antitumor efficacy of biodegradable poly(lactic acid) methotrexate implantable films

U. V. Singh, S. Pandey, P. Umadevi, N. Udupa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Implantable methotrexate films using poly(D,L-lactic acid) and poly(L-lactic acid) (PLA) of different molecular weights were prepared. The in vitro drug release was dependent on the drug loading and molecular weight of the PLA. By blending these polymers in different ratios, the drug release could be controlled and modified. The antitumor efficacy in Sarcoma-180 tumor-bearing mice revealed that the implantable film was more efficacious than subcutaneous injection of plain methotrexate.

Original languageEnglish
Pages (from-to)101-106
Number of pages6
JournalDrug Delivery: Journal of Delivery and Targeting of Therapeutic Agents
Volume4
Issue number2
Publication statusPublished - 04-1997

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Methotrexate
Molecular Weight
Sarcoma 180
Subcutaneous Injections
Lactic Acid
Polymers
Pharmaceutical Preparations
Neoplasms
Drug Liberation
poly(lactic acid)
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

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Preparation, characterization, and antitumor efficacy of biodegradable poly(lactic acid) methotrexate implantable films. / Singh, U. V.; Pandey, S.; Umadevi, P.; Udupa, N.

In: Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents, Vol. 4, No. 2, 04.1997, p. 101-106.

Research output: Contribution to journalArticle

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