Preparation, characterization, and antitumor efficacy of biodegradable poly(lactic acid) methotrexate implantable films

U. V. Singh; S. Pandey; P. Umadevi; N. Udupa

Preparation, characterization, and antitumor efficacy of biodegradable poly(lactic acid) methotrexate implantable films

U. V. Singh, S. Pandey, P. Umadevi, N. Udupa

Research output: Contribution to journal › Article › peer-review

Abstract

Implantable methotrexate films using poly(D,L-lactic acid) and poly(L-lactic acid) (PLA) of different molecular weights were prepared. The in vitro drug release was dependent on the drug loading and molecular weight of the PLA. By blending these polymers in different ratios, the drug release could be controlled and modified. The antitumor efficacy in Sarcoma-180 tumor-bearing mice revealed that the implantable film was more efficacious than subcutaneous injection of plain methotrexate.

Original language	English
Pages (from-to)	101-106
Number of pages	6
Journal	Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents
Volume	4
Issue number	2
Publication status	Published - 04-1997

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

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title = "Preparation, characterization, and antitumor efficacy of biodegradable poly(lactic acid) methotrexate implantable films",

abstract = "Implantable methotrexate films using poly(D,L-lactic acid) and poly(L-lactic acid) (PLA) of different molecular weights were prepared. The in vitro drug release was dependent on the drug loading and molecular weight of the PLA. By blending these polymers in different ratios, the drug release could be controlled and modified. The antitumor efficacy in Sarcoma-180 tumor-bearing mice revealed that the implantable film was more efficacious than subcutaneous injection of plain methotrexate.",

author = "Singh, {U. V.} and S. Pandey and P. Umadevi and N. Udupa",

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AB - Implantable methotrexate films using poly(D,L-lactic acid) and poly(L-lactic acid) (PLA) of different molecular weights were prepared. The in vitro drug release was dependent on the drug loading and molecular weight of the PLA. By blending these polymers in different ratios, the drug release could be controlled and modified. The antitumor efficacy in Sarcoma-180 tumor-bearing mice revealed that the implantable film was more efficacious than subcutaneous injection of plain methotrexate.

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