Preparation, characterization and tissue disposition of niosomes containing isoniazid

Roopa Karki, G. C. Mamatha, G. Subramanya, N. Udupa

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Non-ionic surfactant vesicles (or niosomes) are now widely studied as alternates to liposomes. An increasing number of non-ionic surfactant has been found to form vesicles, capable of entrapping hydrophilic and hydrophobic molecules. Isoniazid encapsulated as formulation using ethanol injection method. A different ratio of cholesterol was used. The formulated systems were characterized for in vitro by size distribution analysis, drug entrapment efficiency and drug release profiles. In vivo drug disposition was evaluated in normal, healthy albino rats for niosomal formulation. The size range 2. 28 ±0. 008(Plain Span 60), 2. 311±0. 009 (Span60: Cholesterol, 40:50), 2. 15±0. 002 (span60: Cholesterol 50:50). The entrapment release 74. 12% (Plain Span 60), 80. 23%(Span60: Cholesterol, 40:50), 76. 26% (span60: Cholesterol, 50:50). In vitro release pattern indicated that about total drug content were released within 48 h. The drug disposition by niosomal drug delivery proved that the drug accumulated in visceral organs (lung, kidney, liver, spleen) was lower than free drug. This proved that niosomal drug delivery system has lesser toxicity than free drug. From the present investigation, it can be concluded that the prepared niosomal drug delivery system of antitubercular agent such as isoniazid has exceptional potential for development into a low dose performed with effective treatment for tuberculosis.

Original languageEnglish
Pages (from-to)224-227
Number of pages4
JournalRasayan Journal of Chemistry
Volume1
Issue number2
Publication statusPublished - 2008

Fingerprint

Cholesterol
Isoniazid
Liposomes
Tissue
Pharmaceutical Preparations
Nonionic surfactants
Drug Delivery Systems
Surface-Active Agents
Drug delivery
Antitubercular Agents
Liver
Toxicity
Rats
Ethanol
Drug-Related Side Effects and Adverse Reactions
Molecules
Tuberculosis
Spleen
Kidney
Lung

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry
  • Chemical Engineering(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Energy(all)

Cite this

Karki, Roopa ; Mamatha, G. C. ; Subramanya, G. ; Udupa, N. / Preparation, characterization and tissue disposition of niosomes containing isoniazid. In: Rasayan Journal of Chemistry. 2008 ; Vol. 1, No. 2. pp. 224-227.
@article{73404bc641e84ccf985bc756cda0b469,
title = "Preparation, characterization and tissue disposition of niosomes containing isoniazid",
abstract = "Non-ionic surfactant vesicles (or niosomes) are now widely studied as alternates to liposomes. An increasing number of non-ionic surfactant has been found to form vesicles, capable of entrapping hydrophilic and hydrophobic molecules. Isoniazid encapsulated as formulation using ethanol injection method. A different ratio of cholesterol was used. The formulated systems were characterized for in vitro by size distribution analysis, drug entrapment efficiency and drug release profiles. In vivo drug disposition was evaluated in normal, healthy albino rats for niosomal formulation. The size range 2. 28 ±0. 008(Plain Span 60), 2. 311±0. 009 (Span60: Cholesterol, 40:50), 2. 15±0. 002 (span60: Cholesterol 50:50). The entrapment release 74. 12{\%} (Plain Span 60), 80. 23{\%}(Span60: Cholesterol, 40:50), 76. 26{\%} (span60: Cholesterol, 50:50). In vitro release pattern indicated that about total drug content were released within 48 h. The drug disposition by niosomal drug delivery proved that the drug accumulated in visceral organs (lung, kidney, liver, spleen) was lower than free drug. This proved that niosomal drug delivery system has lesser toxicity than free drug. From the present investigation, it can be concluded that the prepared niosomal drug delivery system of antitubercular agent such as isoniazid has exceptional potential for development into a low dose performed with effective treatment for tuberculosis.",
author = "Roopa Karki and Mamatha, {G. C.} and G. Subramanya and N. Udupa",
year = "2008",
language = "English",
volume = "1",
pages = "224--227",
journal = "Rasayan Journal of Chemistry",
issn = "0974-1496",
publisher = "Rasayan Journal",
number = "2",

}

Preparation, characterization and tissue disposition of niosomes containing isoniazid. / Karki, Roopa; Mamatha, G. C.; Subramanya, G.; Udupa, N.

In: Rasayan Journal of Chemistry, Vol. 1, No. 2, 2008, p. 224-227.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Preparation, characterization and tissue disposition of niosomes containing isoniazid

AU - Karki, Roopa

AU - Mamatha, G. C.

AU - Subramanya, G.

AU - Udupa, N.

PY - 2008

Y1 - 2008

N2 - Non-ionic surfactant vesicles (or niosomes) are now widely studied as alternates to liposomes. An increasing number of non-ionic surfactant has been found to form vesicles, capable of entrapping hydrophilic and hydrophobic molecules. Isoniazid encapsulated as formulation using ethanol injection method. A different ratio of cholesterol was used. The formulated systems were characterized for in vitro by size distribution analysis, drug entrapment efficiency and drug release profiles. In vivo drug disposition was evaluated in normal, healthy albino rats for niosomal formulation. The size range 2. 28 ±0. 008(Plain Span 60), 2. 311±0. 009 (Span60: Cholesterol, 40:50), 2. 15±0. 002 (span60: Cholesterol 50:50). The entrapment release 74. 12% (Plain Span 60), 80. 23%(Span60: Cholesterol, 40:50), 76. 26% (span60: Cholesterol, 50:50). In vitro release pattern indicated that about total drug content were released within 48 h. The drug disposition by niosomal drug delivery proved that the drug accumulated in visceral organs (lung, kidney, liver, spleen) was lower than free drug. This proved that niosomal drug delivery system has lesser toxicity than free drug. From the present investigation, it can be concluded that the prepared niosomal drug delivery system of antitubercular agent such as isoniazid has exceptional potential for development into a low dose performed with effective treatment for tuberculosis.

AB - Non-ionic surfactant vesicles (or niosomes) are now widely studied as alternates to liposomes. An increasing number of non-ionic surfactant has been found to form vesicles, capable of entrapping hydrophilic and hydrophobic molecules. Isoniazid encapsulated as formulation using ethanol injection method. A different ratio of cholesterol was used. The formulated systems were characterized for in vitro by size distribution analysis, drug entrapment efficiency and drug release profiles. In vivo drug disposition was evaluated in normal, healthy albino rats for niosomal formulation. The size range 2. 28 ±0. 008(Plain Span 60), 2. 311±0. 009 (Span60: Cholesterol, 40:50), 2. 15±0. 002 (span60: Cholesterol 50:50). The entrapment release 74. 12% (Plain Span 60), 80. 23%(Span60: Cholesterol, 40:50), 76. 26% (span60: Cholesterol, 50:50). In vitro release pattern indicated that about total drug content were released within 48 h. The drug disposition by niosomal drug delivery proved that the drug accumulated in visceral organs (lung, kidney, liver, spleen) was lower than free drug. This proved that niosomal drug delivery system has lesser toxicity than free drug. From the present investigation, it can be concluded that the prepared niosomal drug delivery system of antitubercular agent such as isoniazid has exceptional potential for development into a low dose performed with effective treatment for tuberculosis.

UR - http://www.scopus.com/inward/record.url?scp=78149366034&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78149366034&partnerID=8YFLogxK

M3 - Article

VL - 1

SP - 224

EP - 227

JO - Rasayan Journal of Chemistry

JF - Rasayan Journal of Chemistry

SN - 0974-1496

IS - 2

ER -