Preparation, in vitro characterization, pharmacokinetic, and pharmacodynamic evaluation of chitosan-based plumbagin microspheres in mice bearing B16F1 melanoma

S.K. Mandala Rayabandla, K. Aithal, A. Anandam, G. Shavi, U. Nayanabhirama, K. Arumugam, P. Musmade, K. Bhat, S.R. Bola Sadashiva

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The present study was aimed to evaluate the anti-tumor efficacy and systemic toxicity of chitosan-based plumbagin microspheres in comparison to free plumbagin. The optimized formulation had a mean particle size of 106.35 μm with an encapsulation efficiency of 80.12%. Pharmacokinetic studies showed a 22.2-fold increase in elimination half-life (t1/2) of plumbagin from chitosan microspheres as compared to free plumbagin. Administration of plumbagin microspheres resulted in a significant tumor growth inhibition and reduced systemic toxicity. These results suggest that chitosan-based microspheres could be a promising strategy for the systemic delivery of anti-cancer agents like plumbagin. © 2010 Informa UK Ltd.
Original languageEnglish
Pages (from-to)103-113
Number of pages11
JournalDrug Delivery
Volume17
Issue number3
DOIs
Publication statusPublished - 2010

Fingerprint Dive into the research topics of 'Preparation, in vitro characterization, pharmacokinetic, and pharmacodynamic evaluation of chitosan-based plumbagin microspheres in mice bearing B16F1 melanoma'. Together they form a unique fingerprint.

  • Cite this