Preparation of mucoadhesive microspheres for nasal delivery by spray drying

M. Rathananand, D. Kumar, A. Shirwaikar, R. Kumar, D. Sampath Kumar, R. Prasad

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

In this study the suitability of spray drying as a method for the formulation of mucoadhesive microspheres for nasal delivery was evaluated. The microspheres were produced from mucoadhesive polymers including chitosan salt, hydroxypropylmethylcellulose, hydroxypropylcellulose, sodium alginate and contained levocetirizine dihydrochloride as the model drug. The microspheres formed were evaluated for particle size distribution, drug loading, production yield, in vitro release characteristics and suitability for nasal drug delivery in terms of particle size and release properties. The conditions of the spray dryer were optimized for production yield and particle size.
Original languageEnglish
Pages (from-to)651-657
Number of pages7
JournalIndian Journal of Pharmaceutical Sciences
Volume69
Issue number5
Publication statusPublished - 2007

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Nasal Sprays
Microspheres
Particle Size
Nose
Pharmaceutical Preparations
Chitosan
Polymers
Salts

Cite this

Rathananand, M., Kumar, D., Shirwaikar, A., Kumar, R., Sampath Kumar, D., & Prasad, R. (2007). Preparation of mucoadhesive microspheres for nasal delivery by spray drying. Indian Journal of Pharmaceutical Sciences, 69(5), 651-657.
Rathananand, M. ; Kumar, D. ; Shirwaikar, A. ; Kumar, R. ; Sampath Kumar, D. ; Prasad, R. / Preparation of mucoadhesive microspheres for nasal delivery by spray drying. In: Indian Journal of Pharmaceutical Sciences. 2007 ; Vol. 69, No. 5. pp. 651-657.
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author = "M. Rathananand and D. Kumar and A. Shirwaikar and R. Kumar and {Sampath Kumar}, D. and R. Prasad",
note = "Cited By :16 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Rathananand, M.; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal - 576 104, India; email: mlrcops2002@yahoo.co.in Chemicals/CAS: alginic acid, 28961-37-7, 29894-36-8, 9005-32-7, 9005-38-3; chitosan, 9012-76-4; hydroxypropylcellulose, 9004-64-2; hydroxypropylmethylcellulose, 9004-65-3; levocetirizine, 130018-77-8 Manufacturers: symed laboratory, India References: Chien, Y.W., Kenneth, S.E., Chang, S.F., (1989) Nasal systemic delivery, pp. 1-297. , Inc. Marcel Dekker: New York;; Chein, Y.W., Chang, S.F., Intranasal drug delivery for systemic medications (1987) Crit Rev Ther Drug Carrier Syst, 4, pp. 67-194; Chein, Y.W., Chang, S.F., (1985) Transnasal systemic medications: Fundamentals concepts and biomedical assessment, , Chein YW. editors, Elsevier Science Publishers: Amsterdam;; Chang, S.F., Chein, Y.W., Intranasal drug administration for systemic medication (1984) Pharm Int, 5, p. 287; Illum L. Nasal drug delivery-possibilities, problems and solutions. J Control Release 2003;87:187-98; Nagai, T., Machida, Y., Mucosal adhesive dosage forms (1985) Pharm Int, 6, pp. 196-200; Kamath, K.R., Park, K., Mucosal Adhesive preparations (1994) Encyclopedia of Pharmaceutical Technology, p. 133. , Swabrick J. Boylan JC. editors, Marcel Dekker: New York;; Jimenez-Castellanous, M.R., Zia, H., Rhodes, C.T., Mucoadhesive drug delivery (1993) Drug Dev Ind Pharm, 19, pp. 143-194; Morimoto, K., Yamaguchi, H., Iwakura, Y., Morisaka, K., Ohashi, Y., Nakai, Y., Effects of viscous hyaluronate sodium solutions on the nasal absorption of vasopressin and an analogue (1991) Pharm Res, 8, pp. 471-474; Ikeda, K., Murata, K., Kobayashi, M., Noda, K., Enhancement of bioavailability of dopamine via nasal route in beagle dogs (1992) Chem Pharm Bull, 40, pp. 2155-2158; Nagai T, Nishimoto Y, Nambu N, Sekine K. Powder dosage form of insulin for nasal administration. J Control Release 1984;1:15-22; Illum, L., Farraj, N.F., Davis, S.S., Nasal administration of Gentamicin using a novel Microsphere delivery system (1988) Int J Pharm, 46, pp. 261-265; van der Lubben, I.M., van Opdorp, F.A., Hengeveld, M.R., Onderwater, J.J., Koerten, H.K., Verhoef, J.C., Transport of chitosan microparticles for mucosal Vaccine delivery in a Human intestinal M-cell model (2002) J Drug Target, 10, pp. 449-456; Ozbas-Turan, S., Akbuga, J., Aral, C., Controlled release of interleukin-2 from chitosan microspheres (2002) J Pharm Sci, 91, pp. 1245-1251; Has{\cc}i{\cc}ek, C., G{\"o}n{\"u}l, N., Erk, N., Mucoadhesive microspheres containing gentamicin sulfate for nasal administration: Preparation and in vitro characterization (2003) Farmaco, 58, pp. 11-16; He, P., Davis, S.S., Illum, L., In vitro evaluation of the mucoadhesive properties of chitosan microspheres (1998) Int J Pharm, 166, pp. 75-88; Bruschi, M.L., Cardoso, M.L., Lucchesi, M.B., Gremi{\~a}o, M.P., Gelatinmicroparticles containing propolis obtained by spray-drying technique: Preparation and characterization (2003) Int J Pharm, 264, pp. 45-55; Lim ST, Martin GP, Berry DJ, Brown MB. Preparation and evaluation of the in vitro drug release properties and mucoadhesion of novel microspheres of hyaluronic acid and chitosan. J Control Release 2000;66:281-92; Morimoto, K., Katsumata, H., Yabuta, T., Iwanaga, K., Kakemi, M., Tabata, Y., Evaluation of gelatin microspheres for nasal and intramuscular administrations of salmon calcitonin (2001) Eur J Pharm Sci, 13, pp. 179-185; Vidgren, P., Vidgren, M., Arppe, J., Hakuli, T., Laine, E., Paronen, P., In vitro evaluation of spray-dried mucoadhesive microspheres for nasal administration (1992) Drug Develop Ind Pharm, 18, pp. 581-597; Huang, Y.C., Yeh, M.K., Chiang, C.H., Formulation factors in preparing BTM-chitosan microspheres by spray drying method (2002) Int J Pharm, 242, pp. 239-242",
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Rathananand, M, Kumar, D, Shirwaikar, A, Kumar, R, Sampath Kumar, D & Prasad, R 2007, 'Preparation of mucoadhesive microspheres for nasal delivery by spray drying', Indian Journal of Pharmaceutical Sciences, vol. 69, no. 5, pp. 651-657.

Preparation of mucoadhesive microspheres for nasal delivery by spray drying. / Rathananand, M.; Kumar, D.; Shirwaikar, A.; Kumar, R.; Sampath Kumar, D.; Prasad, R.

In: Indian Journal of Pharmaceutical Sciences, Vol. 69, No. 5, 2007, p. 651-657.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Preparation of mucoadhesive microspheres for nasal delivery by spray drying

AU - Rathananand, M.

AU - Kumar, D.

AU - Shirwaikar, A.

AU - Kumar, R.

AU - Sampath Kumar, D.

AU - Prasad, R.

N1 - Cited By :16 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Rathananand, M.; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal - 576 104, India; email: mlrcops2002@yahoo.co.in Chemicals/CAS: alginic acid, 28961-37-7, 29894-36-8, 9005-32-7, 9005-38-3; chitosan, 9012-76-4; hydroxypropylcellulose, 9004-64-2; hydroxypropylmethylcellulose, 9004-65-3; levocetirizine, 130018-77-8 Manufacturers: symed laboratory, India References: Chien, Y.W., Kenneth, S.E., Chang, S.F., (1989) Nasal systemic delivery, pp. 1-297. , Inc. Marcel Dekker: New York;; Chein, Y.W., Chang, S.F., Intranasal drug delivery for systemic medications (1987) Crit Rev Ther Drug Carrier Syst, 4, pp. 67-194; Chein, Y.W., Chang, S.F., (1985) Transnasal systemic medications: Fundamentals concepts and biomedical assessment, , Chein YW. editors, Elsevier Science Publishers: Amsterdam;; Chang, S.F., Chein, Y.W., Intranasal drug administration for systemic medication (1984) Pharm Int, 5, p. 287; Illum L. Nasal drug delivery-possibilities, problems and solutions. J Control Release 2003;87:187-98; Nagai, T., Machida, Y., Mucosal adhesive dosage forms (1985) Pharm Int, 6, pp. 196-200; Kamath, K.R., Park, K., Mucosal Adhesive preparations (1994) Encyclopedia of Pharmaceutical Technology, p. 133. , Swabrick J. Boylan JC. editors, Marcel Dekker: New York;; Jimenez-Castellanous, M.R., Zia, H., Rhodes, C.T., Mucoadhesive drug delivery (1993) Drug Dev Ind Pharm, 19, pp. 143-194; Morimoto, K., Yamaguchi, H., Iwakura, Y., Morisaka, K., Ohashi, Y., Nakai, Y., Effects of viscous hyaluronate sodium solutions on the nasal absorption of vasopressin and an analogue (1991) Pharm Res, 8, pp. 471-474; Ikeda, K., Murata, K., Kobayashi, M., Noda, K., Enhancement of bioavailability of dopamine via nasal route in beagle dogs (1992) Chem Pharm Bull, 40, pp. 2155-2158; Nagai T, Nishimoto Y, Nambu N, Sekine K. Powder dosage form of insulin for nasal administration. J Control Release 1984;1:15-22; Illum, L., Farraj, N.F., Davis, S.S., Nasal administration of Gentamicin using a novel Microsphere delivery system (1988) Int J Pharm, 46, pp. 261-265; van der Lubben, I.M., van Opdorp, F.A., Hengeveld, M.R., Onderwater, J.J., Koerten, H.K., Verhoef, J.C., Transport of chitosan microparticles for mucosal Vaccine delivery in a Human intestinal M-cell model (2002) J Drug Target, 10, pp. 449-456; Ozbas-Turan, S., Akbuga, J., Aral, C., Controlled release of interleukin-2 from chitosan microspheres (2002) J Pharm Sci, 91, pp. 1245-1251; Hasçiçek, C., Gönül, N., Erk, N., Mucoadhesive microspheres containing gentamicin sulfate for nasal administration: Preparation and in vitro characterization (2003) Farmaco, 58, pp. 11-16; He, P., Davis, S.S., Illum, L., In vitro evaluation of the mucoadhesive properties of chitosan microspheres (1998) Int J Pharm, 166, pp. 75-88; Bruschi, M.L., Cardoso, M.L., Lucchesi, M.B., Gremião, M.P., Gelatinmicroparticles containing propolis obtained by spray-drying technique: Preparation and characterization (2003) Int J Pharm, 264, pp. 45-55; Lim ST, Martin GP, Berry DJ, Brown MB. Preparation and evaluation of the in vitro drug release properties and mucoadhesion of novel microspheres of hyaluronic acid and chitosan. J Control Release 2000;66:281-92; Morimoto, K., Katsumata, H., Yabuta, T., Iwanaga, K., Kakemi, M., Tabata, Y., Evaluation of gelatin microspheres for nasal and intramuscular administrations of salmon calcitonin (2001) Eur J Pharm Sci, 13, pp. 179-185; Vidgren, P., Vidgren, M., Arppe, J., Hakuli, T., Laine, E., Paronen, P., In vitro evaluation of spray-dried mucoadhesive microspheres for nasal administration (1992) Drug Develop Ind Pharm, 18, pp. 581-597; Huang, Y.C., Yeh, M.K., Chiang, C.H., Formulation factors in preparing BTM-chitosan microspheres by spray drying method (2002) Int J Pharm, 242, pp. 239-242

PY - 2007

Y1 - 2007

N2 - In this study the suitability of spray drying as a method for the formulation of mucoadhesive microspheres for nasal delivery was evaluated. The microspheres were produced from mucoadhesive polymers including chitosan salt, hydroxypropylmethylcellulose, hydroxypropylcellulose, sodium alginate and contained levocetirizine dihydrochloride as the model drug. The microspheres formed were evaluated for particle size distribution, drug loading, production yield, in vitro release characteristics and suitability for nasal drug delivery in terms of particle size and release properties. The conditions of the spray dryer were optimized for production yield and particle size.

AB - In this study the suitability of spray drying as a method for the formulation of mucoadhesive microspheres for nasal delivery was evaluated. The microspheres were produced from mucoadhesive polymers including chitosan salt, hydroxypropylmethylcellulose, hydroxypropylcellulose, sodium alginate and contained levocetirizine dihydrochloride as the model drug. The microspheres formed were evaluated for particle size distribution, drug loading, production yield, in vitro release characteristics and suitability for nasal drug delivery in terms of particle size and release properties. The conditions of the spray dryer were optimized for production yield and particle size.

M3 - Article

VL - 69

SP - 651

EP - 657

JO - Indian Journal of Pharmaceutical Sciences

JF - Indian Journal of Pharmaceutical Sciences

SN - 0250-474X

IS - 5

ER -