Preparation of mucoadhesive microspheres for nasal delivery by spray drying

M. Rathananand, D. Kumar, A. Shirwaikar, R. Kumar, D. Sampath Kumar, R. Prasad

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

In this study the suitability of spray drying as a method for the formulation of mucoadhesive microspheres for nasal delivery was evaluated. The microspheres were produced from mucoadhesive polymers including chitosan salt, hydroxypropylmethylcellulose, hydroxypropylcellulose, sodium alginate and contained levocetirizine dihydrochloride as the model drug. The microspheres formed were evaluated for particle size distribution, drug loading, production yield, in vitro release characteristics and suitability for nasal drug delivery in terms of particle size and release properties. The conditions of the spray dryer were optimized for production yield and particle size.
Original languageEnglish
Pages (from-to)651-657
Number of pages7
JournalIndian Journal of Pharmaceutical Sciences
Volume69
Issue number5
Publication statusPublished - 2007

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