Prevalence and antibiotic susceptibility pattern of methicillin resistant Staphylococcus aureus in diabetic foot ulcer

M. S. Nandini, Kiran Madhusadhan

Research output: Contribution to journalArticle

Abstract

Diabetic foot ulcer(DFU) is the most common complication in diabetic patients, infection has led to increased mortality and sometimes may lead to amputation of limb. Staphylococcus aureus is the most common organism causing infection in DFU, and there is high prevalence of Methicillin-resistant Staphylococcus aureus (MRSA) among them. MRSA is a virulent organism causing delayed wound healing and mortality. To determine the prevalence of Methicillin resistant Staphylococcus aureus in diabetic foot ulcer and to determine antimicrobial susceptibility pattern among MRSA strains. A prospective study pus samples / wound swab were cultured from 100 patients who attented out patients and in patients at diabetic foot clinic with diabetic foot ulcer. Specimens were subjected to routine microbiological study, and antibiotic susceptibility was done by Kirby- Baurer disk diffusion test. Out of 100 wound samples 143organisms were isolated, of which 31(21.67%) were staphylococcus aureus. These isolates were tested for Methicillin susceptibility and was found that 13 (41.93%) were resistant and 18(57.8%) were susceptible. These MRSA strains showed high resistance to Ampicillin (100%), Penicillin (100%), tetracycline (70.3%), Amoxycillin (69.23%), and MRSA isolates were sensitive to Vancomycin (100%), Linezolid (100%) Erthromycin (66%) and Amoxycillin/clavulanic acid (69.3%). There is high prevalence of MRSA among diabetic foot ulcers.

Original languageEnglish
Pages (from-to)432-435
Number of pages4
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume6
Issue number6
Publication statusPublished - 01-01-2015

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Diabetic Foot
Methicillin
Methicillin-Resistant Staphylococcus aureus
Anti-Bacterial Agents
Linezolid
Staphylococcus aureus
Ampicillin Resistance
Amoxicillin-Potassium Clavulanate Combination
Suppuration
Mortality
Amoxicillin
Wounds and Injuries
Diabetes Complications
Vancomycin
Infection
Tetracycline
Amputation
Penicillins
Wound Healing
Ampicillin

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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abstract = "Diabetic foot ulcer(DFU) is the most common complication in diabetic patients, infection has led to increased mortality and sometimes may lead to amputation of limb. Staphylococcus aureus is the most common organism causing infection in DFU, and there is high prevalence of Methicillin-resistant Staphylococcus aureus (MRSA) among them. MRSA is a virulent organism causing delayed wound healing and mortality. To determine the prevalence of Methicillin resistant Staphylococcus aureus in diabetic foot ulcer and to determine antimicrobial susceptibility pattern among MRSA strains. A prospective study pus samples / wound swab were cultured from 100 patients who attented out patients and in patients at diabetic foot clinic with diabetic foot ulcer. Specimens were subjected to routine microbiological study, and antibiotic susceptibility was done by Kirby- Baurer disk diffusion test. Out of 100 wound samples 143organisms were isolated, of which 31(21.67{\%}) were staphylococcus aureus. These isolates were tested for Methicillin susceptibility and was found that 13 (41.93{\%}) were resistant and 18(57.8{\%}) were susceptible. These MRSA strains showed high resistance to Ampicillin (100{\%}), Penicillin (100{\%}), tetracycline (70.3{\%}), Amoxycillin (69.23{\%}), and MRSA isolates were sensitive to Vancomycin (100{\%}), Linezolid (100{\%}) Erthromycin (66{\%}) and Amoxycillin/clavulanic acid (69.3{\%}). There is high prevalence of MRSA among diabetic foot ulcers.",
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