Prevalence of angle-closure disease in a rural southern Indian population

Lingam Vijaya, Ronnie George, Hemamalini Arvind, M. Baskaran, Pradeep G. Paul, S. Ve Ramesh, Prema Raju, Govindasamy Kumaramanickavel, Catherine McCarty

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Abstract

Objective: To estimate the prevalence of primary angle-closure glaucoma, primary angle closure (PAC), and primary angle-closure suspect (PACS) and its associated risk factors in a rural population in southern India. Methods: Three thousand and nine hundred thirty-four (81.95%) of 4800 enumerated subjects aged 40 years or older underwent a complete ophthalmic examination, including compression gonioscopy. Glaucoma was diagnosed using International Society of Geographical and Epidemiological Ophthalmology classification. Results: Data were analyzed for 3924 subjects (81.75%). Primary angle-closure glaucoma was diagnosed in 34 subjects (0.87%; 95% confidence interval [CI], 0.58 to 1.16) (27 women, 7 men). The mean intraocular pressure was 20.71 ± 9.24 mm Hg. One subject (2.94%) was blind. Twenty-eight subjects (0.71%; 95% CI, 0.45 to 0.98) were diagnosed to have PAC (21 women, 7 men). Eleven subjects (39.3%) had an intraocular pressure greater than 21 mm Hg, 13 subjects (46.43%) had peripheral anterior synechiae, and 4 subjects (14.29%) had both. Two hundred forty-six subjects (6.27%; 95% CI, 5.51 to 7.03) had PACS (168 women, 78 men). Primary angle closure and primary angle-closure glaucoma were more common in women (age-adjusted odds ratio, 3.02; 95% CI, 1.66 to 5.51) with an increasing prevalence with age. Increasing intraocular pressure was associated with the disease (odds ratio, 1.14; 95% CI, 1.09 to 1.19). There was no association with hypertension and hyperopia. Axial length and anterior chamber depth were longer in the normal group than in the 3 groups with angle closure (P<.05). Women had shorter axial lengths than men (P<.001) in the angle closure groups. Conclusions: The overall prevalence of primary angle closures (PAC and primary angle-closure glaucoma) in a rural population of southern India was 1.58%. There was a female preponderance, and the disease tends to be asymptomatic.

Original languageEnglish
Pages (from-to)403-409
Number of pages7
JournalArchives of Ophthalmology
Volume124
Issue number3
DOIs
Publication statusPublished - 01-03-2006

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Angle Closure Glaucoma
Confidence Intervals
Intraocular Pressure
Population
Rural Population
India
Odds Ratio
Gonioscopy
Hyperopia
Anterior Chamber
Ophthalmology
Glaucoma
Hypertension

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Vijaya, L., George, R., Arvind, H., Baskaran, M., Paul, P. G., Ramesh, S. V., ... McCarty, C. (2006). Prevalence of angle-closure disease in a rural southern Indian population. Archives of Ophthalmology, 124(3), 403-409. https://doi.org/10.1001/archopht.124.3.403
Vijaya, Lingam ; George, Ronnie ; Arvind, Hemamalini ; Baskaran, M. ; Paul, Pradeep G. ; Ramesh, S. Ve ; Raju, Prema ; Kumaramanickavel, Govindasamy ; McCarty, Catherine. / Prevalence of angle-closure disease in a rural southern Indian population. In: Archives of Ophthalmology. 2006 ; Vol. 124, No. 3. pp. 403-409.
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abstract = "Objective: To estimate the prevalence of primary angle-closure glaucoma, primary angle closure (PAC), and primary angle-closure suspect (PACS) and its associated risk factors in a rural population in southern India. Methods: Three thousand and nine hundred thirty-four (81.95{\%}) of 4800 enumerated subjects aged 40 years or older underwent a complete ophthalmic examination, including compression gonioscopy. Glaucoma was diagnosed using International Society of Geographical and Epidemiological Ophthalmology classification. Results: Data were analyzed for 3924 subjects (81.75{\%}). Primary angle-closure glaucoma was diagnosed in 34 subjects (0.87{\%}; 95{\%} confidence interval [CI], 0.58 to 1.16) (27 women, 7 men). The mean intraocular pressure was 20.71 ± 9.24 mm Hg. One subject (2.94{\%}) was blind. Twenty-eight subjects (0.71{\%}; 95{\%} CI, 0.45 to 0.98) were diagnosed to have PAC (21 women, 7 men). Eleven subjects (39.3{\%}) had an intraocular pressure greater than 21 mm Hg, 13 subjects (46.43{\%}) had peripheral anterior synechiae, and 4 subjects (14.29{\%}) had both. Two hundred forty-six subjects (6.27{\%}; 95{\%} CI, 5.51 to 7.03) had PACS (168 women, 78 men). Primary angle closure and primary angle-closure glaucoma were more common in women (age-adjusted odds ratio, 3.02; 95{\%} CI, 1.66 to 5.51) with an increasing prevalence with age. Increasing intraocular pressure was associated with the disease (odds ratio, 1.14; 95{\%} CI, 1.09 to 1.19). There was no association with hypertension and hyperopia. Axial length and anterior chamber depth were longer in the normal group than in the 3 groups with angle closure (P<.05). Women had shorter axial lengths than men (P<.001) in the angle closure groups. Conclusions: The overall prevalence of primary angle closures (PAC and primary angle-closure glaucoma) in a rural population of southern India was 1.58{\%}. There was a female preponderance, and the disease tends to be asymptomatic.",
author = "Lingam Vijaya and Ronnie George and Hemamalini Arvind and M. Baskaran and Paul, {Pradeep G.} and Ramesh, {S. Ve} and Prema Raju and Govindasamy Kumaramanickavel and Catherine McCarty",
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Vijaya, L, George, R, Arvind, H, Baskaran, M, Paul, PG, Ramesh, SV, Raju, P, Kumaramanickavel, G & McCarty, C 2006, 'Prevalence of angle-closure disease in a rural southern Indian population', Archives of Ophthalmology, vol. 124, no. 3, pp. 403-409. https://doi.org/10.1001/archopht.124.3.403

Prevalence of angle-closure disease in a rural southern Indian population. / Vijaya, Lingam; George, Ronnie; Arvind, Hemamalini; Baskaran, M.; Paul, Pradeep G.; Ramesh, S. Ve; Raju, Prema; Kumaramanickavel, Govindasamy; McCarty, Catherine.

In: Archives of Ophthalmology, Vol. 124, No. 3, 01.03.2006, p. 403-409.

Research output: Contribution to journalArticle

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T1 - Prevalence of angle-closure disease in a rural southern Indian population

AU - Vijaya, Lingam

AU - George, Ronnie

AU - Arvind, Hemamalini

AU - Baskaran, M.

AU - Paul, Pradeep G.

AU - Ramesh, S. Ve

AU - Raju, Prema

AU - Kumaramanickavel, Govindasamy

AU - McCarty, Catherine

PY - 2006/3/1

Y1 - 2006/3/1

N2 - Objective: To estimate the prevalence of primary angle-closure glaucoma, primary angle closure (PAC), and primary angle-closure suspect (PACS) and its associated risk factors in a rural population in southern India. Methods: Three thousand and nine hundred thirty-four (81.95%) of 4800 enumerated subjects aged 40 years or older underwent a complete ophthalmic examination, including compression gonioscopy. Glaucoma was diagnosed using International Society of Geographical and Epidemiological Ophthalmology classification. Results: Data were analyzed for 3924 subjects (81.75%). Primary angle-closure glaucoma was diagnosed in 34 subjects (0.87%; 95% confidence interval [CI], 0.58 to 1.16) (27 women, 7 men). The mean intraocular pressure was 20.71 ± 9.24 mm Hg. One subject (2.94%) was blind. Twenty-eight subjects (0.71%; 95% CI, 0.45 to 0.98) were diagnosed to have PAC (21 women, 7 men). Eleven subjects (39.3%) had an intraocular pressure greater than 21 mm Hg, 13 subjects (46.43%) had peripheral anterior synechiae, and 4 subjects (14.29%) had both. Two hundred forty-six subjects (6.27%; 95% CI, 5.51 to 7.03) had PACS (168 women, 78 men). Primary angle closure and primary angle-closure glaucoma were more common in women (age-adjusted odds ratio, 3.02; 95% CI, 1.66 to 5.51) with an increasing prevalence with age. Increasing intraocular pressure was associated with the disease (odds ratio, 1.14; 95% CI, 1.09 to 1.19). There was no association with hypertension and hyperopia. Axial length and anterior chamber depth were longer in the normal group than in the 3 groups with angle closure (P<.05). Women had shorter axial lengths than men (P<.001) in the angle closure groups. Conclusions: The overall prevalence of primary angle closures (PAC and primary angle-closure glaucoma) in a rural population of southern India was 1.58%. There was a female preponderance, and the disease tends to be asymptomatic.

AB - Objective: To estimate the prevalence of primary angle-closure glaucoma, primary angle closure (PAC), and primary angle-closure suspect (PACS) and its associated risk factors in a rural population in southern India. Methods: Three thousand and nine hundred thirty-four (81.95%) of 4800 enumerated subjects aged 40 years or older underwent a complete ophthalmic examination, including compression gonioscopy. Glaucoma was diagnosed using International Society of Geographical and Epidemiological Ophthalmology classification. Results: Data were analyzed for 3924 subjects (81.75%). Primary angle-closure glaucoma was diagnosed in 34 subjects (0.87%; 95% confidence interval [CI], 0.58 to 1.16) (27 women, 7 men). The mean intraocular pressure was 20.71 ± 9.24 mm Hg. One subject (2.94%) was blind. Twenty-eight subjects (0.71%; 95% CI, 0.45 to 0.98) were diagnosed to have PAC (21 women, 7 men). Eleven subjects (39.3%) had an intraocular pressure greater than 21 mm Hg, 13 subjects (46.43%) had peripheral anterior synechiae, and 4 subjects (14.29%) had both. Two hundred forty-six subjects (6.27%; 95% CI, 5.51 to 7.03) had PACS (168 women, 78 men). Primary angle closure and primary angle-closure glaucoma were more common in women (age-adjusted odds ratio, 3.02; 95% CI, 1.66 to 5.51) with an increasing prevalence with age. Increasing intraocular pressure was associated with the disease (odds ratio, 1.14; 95% CI, 1.09 to 1.19). There was no association with hypertension and hyperopia. Axial length and anterior chamber depth were longer in the normal group than in the 3 groups with angle closure (P<.05). Women had shorter axial lengths than men (P<.001) in the angle closure groups. Conclusions: The overall prevalence of primary angle closures (PAC and primary angle-closure glaucoma) in a rural population of southern India was 1.58%. There was a female preponderance, and the disease tends to be asymptomatic.

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