Prevalence of open-angle glaucoma in a rural south Indian population

Lingam Vijaya, Ronnie George, Pradeep G. Paul, Mani Baskaran, Hemamalini Arvind, Prema Raju, S. Ve Ramesh, Govindasamy Kumaramanickavel, Catherine McCarty

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Abstract

PURPOSE. To determine the prevalence of primary open-angle glaucoma (POAG) and the associated risk factors in a rural population in southern India. METHODS. Subjects aged 40 years or more (n = 3934) underwent a complete ophthalmic examination. Glaucoma was diagnosed according to the International Society of Geographical and Epidemiologic Ophthalmology classification. RESULTS. Complete data were available for 3924 subjects (response rate, 81.75%). In eyes with normal suprathreshold visual fields, the mean intraocular pressure was 14.29 ± 3.32 mm Hg (97.5th and 99.5th percentiles, 21 and 25 mm Hg, respectively). The mean vertical cup-to-disc ratio was 0.39 ± 0.17 (97.5th and 99.5th percentiles, 0.7 and 0.8, respectively). Sixty-four subjects had definite POAG (1.62%, 9.5% CI 1.42-1.82); 30 were men and 34 were women. Subjects with POAG (59.85 ± 10.43 years) were older (P < 0.001) than the study population (53.78 ± 10.71 years). In only one (1.5%) person was POAG diagnosed before the study. Two (3.12%) subjects were blind due to POAG; 21 (32.81%) subjects had a presenting IOP >21 mm Hg, and 43 (67.19%) had an IOP <21 mm Hg. The mean central corneal thickness in subjects with POAG (502.82 ± 35.29 μm) was not different from that of the normal study population (505.93 ± 31.11 μm). No association was found with diabetes mellitus, systemic hypertension, gender, and myopia. Increasing IOP (per mm Hg) was associated with the disease (OR 1.12; 95% CI, 1.08-1.16). The odds for POAG increased with advancing age after adjustment for gender. CONCLUSIONS. The prevalence of POAG in this population was 1.62%. The prevalence increased with age, and 98.5% were not aware of the disease.

Original languageEnglish
Pages (from-to)4461-4467
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume46
Issue number12
DOIs
Publication statusPublished - 01-12-2005

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Open Angle Glaucoma
Population
Myopia
Rural Population
Ophthalmology
Visual Fields
Intraocular Pressure
Glaucoma
Primary Open Angle Glaucoma
India
Diabetes Mellitus
Hypertension

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Vijaya, L., George, R., Paul, P. G., Baskaran, M., Arvind, H., Raju, P., ... McCarty, C. (2005). Prevalence of open-angle glaucoma in a rural south Indian population. Investigative Ophthalmology and Visual Science, 46(12), 4461-4467. https://doi.org/10.1167/iovs.04-1529
Vijaya, Lingam ; George, Ronnie ; Paul, Pradeep G. ; Baskaran, Mani ; Arvind, Hemamalini ; Raju, Prema ; Ve Ramesh, S. ; Kumaramanickavel, Govindasamy ; McCarty, Catherine. / Prevalence of open-angle glaucoma in a rural south Indian population. In: Investigative Ophthalmology and Visual Science. 2005 ; Vol. 46, No. 12. pp. 4461-4467.
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abstract = "PURPOSE. To determine the prevalence of primary open-angle glaucoma (POAG) and the associated risk factors in a rural population in southern India. METHODS. Subjects aged 40 years or more (n = 3934) underwent a complete ophthalmic examination. Glaucoma was diagnosed according to the International Society of Geographical and Epidemiologic Ophthalmology classification. RESULTS. Complete data were available for 3924 subjects (response rate, 81.75{\%}). In eyes with normal suprathreshold visual fields, the mean intraocular pressure was 14.29 ± 3.32 mm Hg (97.5th and 99.5th percentiles, 21 and 25 mm Hg, respectively). The mean vertical cup-to-disc ratio was 0.39 ± 0.17 (97.5th and 99.5th percentiles, 0.7 and 0.8, respectively). Sixty-four subjects had definite POAG (1.62{\%}, 9.5{\%} CI 1.42-1.82); 30 were men and 34 were women. Subjects with POAG (59.85 ± 10.43 years) were older (P < 0.001) than the study population (53.78 ± 10.71 years). In only one (1.5{\%}) person was POAG diagnosed before the study. Two (3.12{\%}) subjects were blind due to POAG; 21 (32.81{\%}) subjects had a presenting IOP >21 mm Hg, and 43 (67.19{\%}) had an IOP <21 mm Hg. The mean central corneal thickness in subjects with POAG (502.82 ± 35.29 μm) was not different from that of the normal study population (505.93 ± 31.11 μm). No association was found with diabetes mellitus, systemic hypertension, gender, and myopia. Increasing IOP (per mm Hg) was associated with the disease (OR 1.12; 95{\%} CI, 1.08-1.16). The odds for POAG increased with advancing age after adjustment for gender. CONCLUSIONS. The prevalence of POAG in this population was 1.62{\%}. The prevalence increased with age, and 98.5{\%} were not aware of the disease.",
author = "Lingam Vijaya and Ronnie George and Paul, {Pradeep G.} and Mani Baskaran and Hemamalini Arvind and Prema Raju and {Ve Ramesh}, S. and Govindasamy Kumaramanickavel and Catherine McCarty",
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Vijaya, L, George, R, Paul, PG, Baskaran, M, Arvind, H, Raju, P, Ve Ramesh, S, Kumaramanickavel, G & McCarty, C 2005, 'Prevalence of open-angle glaucoma in a rural south Indian population', Investigative Ophthalmology and Visual Science, vol. 46, no. 12, pp. 4461-4467. https://doi.org/10.1167/iovs.04-1529

Prevalence of open-angle glaucoma in a rural south Indian population. / Vijaya, Lingam; George, Ronnie; Paul, Pradeep G.; Baskaran, Mani; Arvind, Hemamalini; Raju, Prema; Ve Ramesh, S.; Kumaramanickavel, Govindasamy; McCarty, Catherine.

In: Investigative Ophthalmology and Visual Science, Vol. 46, No. 12, 01.12.2005, p. 4461-4467.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prevalence of open-angle glaucoma in a rural south Indian population

AU - Vijaya, Lingam

AU - George, Ronnie

AU - Paul, Pradeep G.

AU - Baskaran, Mani

AU - Arvind, Hemamalini

AU - Raju, Prema

AU - Ve Ramesh, S.

AU - Kumaramanickavel, Govindasamy

AU - McCarty, Catherine

PY - 2005/12/1

Y1 - 2005/12/1

N2 - PURPOSE. To determine the prevalence of primary open-angle glaucoma (POAG) and the associated risk factors in a rural population in southern India. METHODS. Subjects aged 40 years or more (n = 3934) underwent a complete ophthalmic examination. Glaucoma was diagnosed according to the International Society of Geographical and Epidemiologic Ophthalmology classification. RESULTS. Complete data were available for 3924 subjects (response rate, 81.75%). In eyes with normal suprathreshold visual fields, the mean intraocular pressure was 14.29 ± 3.32 mm Hg (97.5th and 99.5th percentiles, 21 and 25 mm Hg, respectively). The mean vertical cup-to-disc ratio was 0.39 ± 0.17 (97.5th and 99.5th percentiles, 0.7 and 0.8, respectively). Sixty-four subjects had definite POAG (1.62%, 9.5% CI 1.42-1.82); 30 were men and 34 were women. Subjects with POAG (59.85 ± 10.43 years) were older (P < 0.001) than the study population (53.78 ± 10.71 years). In only one (1.5%) person was POAG diagnosed before the study. Two (3.12%) subjects were blind due to POAG; 21 (32.81%) subjects had a presenting IOP >21 mm Hg, and 43 (67.19%) had an IOP <21 mm Hg. The mean central corneal thickness in subjects with POAG (502.82 ± 35.29 μm) was not different from that of the normal study population (505.93 ± 31.11 μm). No association was found with diabetes mellitus, systemic hypertension, gender, and myopia. Increasing IOP (per mm Hg) was associated with the disease (OR 1.12; 95% CI, 1.08-1.16). The odds for POAG increased with advancing age after adjustment for gender. CONCLUSIONS. The prevalence of POAG in this population was 1.62%. The prevalence increased with age, and 98.5% were not aware of the disease.

AB - PURPOSE. To determine the prevalence of primary open-angle glaucoma (POAG) and the associated risk factors in a rural population in southern India. METHODS. Subjects aged 40 years or more (n = 3934) underwent a complete ophthalmic examination. Glaucoma was diagnosed according to the International Society of Geographical and Epidemiologic Ophthalmology classification. RESULTS. Complete data were available for 3924 subjects (response rate, 81.75%). In eyes with normal suprathreshold visual fields, the mean intraocular pressure was 14.29 ± 3.32 mm Hg (97.5th and 99.5th percentiles, 21 and 25 mm Hg, respectively). The mean vertical cup-to-disc ratio was 0.39 ± 0.17 (97.5th and 99.5th percentiles, 0.7 and 0.8, respectively). Sixty-four subjects had definite POAG (1.62%, 9.5% CI 1.42-1.82); 30 were men and 34 were women. Subjects with POAG (59.85 ± 10.43 years) were older (P < 0.001) than the study population (53.78 ± 10.71 years). In only one (1.5%) person was POAG diagnosed before the study. Two (3.12%) subjects were blind due to POAG; 21 (32.81%) subjects had a presenting IOP >21 mm Hg, and 43 (67.19%) had an IOP <21 mm Hg. The mean central corneal thickness in subjects with POAG (502.82 ± 35.29 μm) was not different from that of the normal study population (505.93 ± 31.11 μm). No association was found with diabetes mellitus, systemic hypertension, gender, and myopia. Increasing IOP (per mm Hg) was associated with the disease (OR 1.12; 95% CI, 1.08-1.16). The odds for POAG increased with advancing age after adjustment for gender. CONCLUSIONS. The prevalence of POAG in this population was 1.62%. The prevalence increased with age, and 98.5% were not aware of the disease.

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