Prevalence of open-angle glaucoma in a rural south Indian population

Lingam Vijaya, Ronnie George, Pradeep G. Paul, Mani Baskaran, Hemamalini Arvind, Prema Raju, S. Ve Ramesh, Govindasamy Kumaramanickavel, Catherine McCarty

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Abstract

PURPOSE. To determine the prevalence of primary open-angle glaucoma (POAG) and the associated risk factors in a rural population in southern India. METHODS. Subjects aged 40 years or more (n = 3934) underwent a complete ophthalmic examination. Glaucoma was diagnosed according to the International Society of Geographical and Epidemiologic Ophthalmology classification. RESULTS. Complete data were available for 3924 subjects (response rate, 81.75%). In eyes with normal suprathreshold visual fields, the mean intraocular pressure was 14.29 ± 3.32 mm Hg (97.5th and 99.5th percentiles, 21 and 25 mm Hg, respectively). The mean vertical cup-to-disc ratio was 0.39 ± 0.17 (97.5th and 99.5th percentiles, 0.7 and 0.8, respectively). Sixty-four subjects had definite POAG (1.62%, 9.5% CI 1.42-1.82); 30 were men and 34 were women. Subjects with POAG (59.85 ± 10.43 years) were older (P < 0.001) than the study population (53.78 ± 10.71 years). In only one (1.5%) person was POAG diagnosed before the study. Two (3.12%) subjects were blind due to POAG; 21 (32.81%) subjects had a presenting IOP >21 mm Hg, and 43 (67.19%) had an IOP <21 mm Hg. The mean central corneal thickness in subjects with POAG (502.82 ± 35.29 μm) was not different from that of the normal study population (505.93 ± 31.11 μm). No association was found with diabetes mellitus, systemic hypertension, gender, and myopia. Increasing IOP (per mm Hg) was associated with the disease (OR 1.12; 95% CI, 1.08-1.16). The odds for POAG increased with advancing age after adjustment for gender. CONCLUSIONS. The prevalence of POAG in this population was 1.62%. The prevalence increased with age, and 98.5% were not aware of the disease.

Original languageEnglish
Pages (from-to)4461-4467
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume46
Issue number12
DOIs
Publication statusPublished - 01-12-2005

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All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Vijaya, L., George, R., Paul, P. G., Baskaran, M., Arvind, H., Raju, P., Ve Ramesh, S., Kumaramanickavel, G., & McCarty, C. (2005). Prevalence of open-angle glaucoma in a rural south Indian population. Investigative Ophthalmology and Visual Science, 46(12), 4461-4467. https://doi.org/10.1167/iovs.04-1529