Prevalence of Vitamin B12 and folic acid deficiency in HIV-positive patients and its association with neuropsychiatric symptoms and immunological response

Prabha Adhikari, Mukta Chowta, John Ramapuram, Satish Rao, Karthik Udupa, Sahana Acharya

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2 Citations (Scopus)

Abstract

Background: Deficiency of micronutrients is prevalent even before the development of symptoms of HIV disease and is associated with accelerated HIV disease progression. Aims: This study evaluates the prevalence of folate and Vitamin B12deficiency in HIV-positive patients with or without tuberculosis (TB) and its association with neuropsychiatric symptoms and immunological response. Settings and Design: Cross-sectional, observational study in an outpatient setting. Patients and Methods: Four groups of HIV-positive patients with TB (Group I), HIV-positive patients with neuropsychiatric symptoms (Group II), HIV-positive patients without neuropsychiatric symptoms or TB (Group III), and HIV-negative controls with neuropsychiatric symptoms (Group IV). Vitamin B12and folate estimation was done using carbonyl metallo-immunoassay method. Statistical Analysis Used: ANOVA, Kruskal-Wallis and Mann-Whitney, Pearson's correlation. Results: The prevalence of folic acid deficiency was 27.1% in the Group I, 31.9% in the Group II, 23.4% in the Group III, and 32% in the Group IV being higher in patients with neuropsychiatric symptoms in both HIV and non-HIV patients. The prevalence of Vitamin B12deficiency was 18.8% in Group I, 9.1% in Group II, 4.8% in Group III, and 16.7% in Group IV. The patients with folate deficiency had more severe depression and anxiety. Conclusion: Nearly, 30% of the HIV patients had a folic acid deficiency, and about 10% of the HIV patients had Vitamin B12deficiency. The folate deficiency was highest among neuropsychiatric patients with or without HIV infection and Vitamin B12deficiency was higher among HIV patients with TB.

Original languageEnglish
Pages (from-to)178-184
Number of pages7
JournalIndian Journal of Sexually Transmitted Diseases
Volume37
Issue number2
DOIs
Publication statusPublished - 01-07-2016

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Folic Acid Deficiency
Vitamin B 12
HIV
Vitamins
Folic Acid
Tuberculosis
Cross-Sectional Studies
Micronutrients
Immunoassay
HIV Infections
Observational Studies

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

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title = "Prevalence of Vitamin B12 and folic acid deficiency in HIV-positive patients and its association with neuropsychiatric symptoms and immunological response",
abstract = "Background: Deficiency of micronutrients is prevalent even before the development of symptoms of HIV disease and is associated with accelerated HIV disease progression. Aims: This study evaluates the prevalence of folate and Vitamin B12deficiency in HIV-positive patients with or without tuberculosis (TB) and its association with neuropsychiatric symptoms and immunological response. Settings and Design: Cross-sectional, observational study in an outpatient setting. Patients and Methods: Four groups of HIV-positive patients with TB (Group I), HIV-positive patients with neuropsychiatric symptoms (Group II), HIV-positive patients without neuropsychiatric symptoms or TB (Group III), and HIV-negative controls with neuropsychiatric symptoms (Group IV). Vitamin B12and folate estimation was done using carbonyl metallo-immunoassay method. Statistical Analysis Used: ANOVA, Kruskal-Wallis and Mann-Whitney, Pearson's correlation. Results: The prevalence of folic acid deficiency was 27.1{\%} in the Group I, 31.9{\%} in the Group II, 23.4{\%} in the Group III, and 32{\%} in the Group IV being higher in patients with neuropsychiatric symptoms in both HIV and non-HIV patients. The prevalence of Vitamin B12deficiency was 18.8{\%} in Group I, 9.1{\%} in Group II, 4.8{\%} in Group III, and 16.7{\%} in Group IV. The patients with folate deficiency had more severe depression and anxiety. Conclusion: Nearly, 30{\%} of the HIV patients had a folic acid deficiency, and about 10{\%} of the HIV patients had Vitamin B12deficiency. The folate deficiency was highest among neuropsychiatric patients with or without HIV infection and Vitamin B12deficiency was higher among HIV patients with TB.",
author = "Prabha Adhikari and Mukta Chowta and John Ramapuram and Satish Rao and Karthik Udupa and Sahana Acharya",
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T1 - Prevalence of Vitamin B12 and folic acid deficiency in HIV-positive patients and its association with neuropsychiatric symptoms and immunological response

AU - Adhikari, Prabha

AU - Chowta, Mukta

AU - Ramapuram, John

AU - Rao, Satish

AU - Udupa, Karthik

AU - Acharya, Sahana

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Background: Deficiency of micronutrients is prevalent even before the development of symptoms of HIV disease and is associated with accelerated HIV disease progression. Aims: This study evaluates the prevalence of folate and Vitamin B12deficiency in HIV-positive patients with or without tuberculosis (TB) and its association with neuropsychiatric symptoms and immunological response. Settings and Design: Cross-sectional, observational study in an outpatient setting. Patients and Methods: Four groups of HIV-positive patients with TB (Group I), HIV-positive patients with neuropsychiatric symptoms (Group II), HIV-positive patients without neuropsychiatric symptoms or TB (Group III), and HIV-negative controls with neuropsychiatric symptoms (Group IV). Vitamin B12and folate estimation was done using carbonyl metallo-immunoassay method. Statistical Analysis Used: ANOVA, Kruskal-Wallis and Mann-Whitney, Pearson's correlation. Results: The prevalence of folic acid deficiency was 27.1% in the Group I, 31.9% in the Group II, 23.4% in the Group III, and 32% in the Group IV being higher in patients with neuropsychiatric symptoms in both HIV and non-HIV patients. The prevalence of Vitamin B12deficiency was 18.8% in Group I, 9.1% in Group II, 4.8% in Group III, and 16.7% in Group IV. The patients with folate deficiency had more severe depression and anxiety. Conclusion: Nearly, 30% of the HIV patients had a folic acid deficiency, and about 10% of the HIV patients had Vitamin B12deficiency. The folate deficiency was highest among neuropsychiatric patients with or without HIV infection and Vitamin B12deficiency was higher among HIV patients with TB.

AB - Background: Deficiency of micronutrients is prevalent even before the development of symptoms of HIV disease and is associated with accelerated HIV disease progression. Aims: This study evaluates the prevalence of folate and Vitamin B12deficiency in HIV-positive patients with or without tuberculosis (TB) and its association with neuropsychiatric symptoms and immunological response. Settings and Design: Cross-sectional, observational study in an outpatient setting. Patients and Methods: Four groups of HIV-positive patients with TB (Group I), HIV-positive patients with neuropsychiatric symptoms (Group II), HIV-positive patients without neuropsychiatric symptoms or TB (Group III), and HIV-negative controls with neuropsychiatric symptoms (Group IV). Vitamin B12and folate estimation was done using carbonyl metallo-immunoassay method. Statistical Analysis Used: ANOVA, Kruskal-Wallis and Mann-Whitney, Pearson's correlation. Results: The prevalence of folic acid deficiency was 27.1% in the Group I, 31.9% in the Group II, 23.4% in the Group III, and 32% in the Group IV being higher in patients with neuropsychiatric symptoms in both HIV and non-HIV patients. The prevalence of Vitamin B12deficiency was 18.8% in Group I, 9.1% in Group II, 4.8% in Group III, and 16.7% in Group IV. The patients with folate deficiency had more severe depression and anxiety. Conclusion: Nearly, 30% of the HIV patients had a folic acid deficiency, and about 10% of the HIV patients had Vitamin B12deficiency. The folate deficiency was highest among neuropsychiatric patients with or without HIV infection and Vitamin B12deficiency was higher among HIV patients with TB.

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U2 - 10.4103/0253-7184.192117

DO - 10.4103/0253-7184.192117

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JO - Indian Journal of Sexually Transmitted Diseases

JF - Indian Journal of Sexually Transmitted Diseases

SN - 0253-7184

IS - 2

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