Prevalence of vitamin D deficiency and its relationship with subclinical hypothyroidism

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Abstract

Vitamin D deficiency has been implicated in various diseases including cancer and auto immune diseases. The present study attempts to establish a relation between vitamin D deficiency, thyroid hormones and TSH in subclinical hypothyroidism.100 newly diagnosed patients with subclinical hypothyroidism were divided into three groups according to vitamin D levels. Mean plasma TSH and T3 values decreased with increasing vitamin D values and T4 increased with increasing vitamin D tertiles. However, intergroup comparison showed no statistically significant changes. In females, negative correlation between vitamin D and TSH was statistically significant (p=0.014).The prevalence of vitamin D deficiency, insufficiency and sufficiency in 100 patients was found to be 38%, 38% and 24%. The study indicates the prevalence of vitamin D deficiency in subclinical hypothyroidism, but further studies are needed to determine whether it is a causative factor in the pathogenesis of the disease or a consequence.

Original languageEnglish
JournalInternational Journal of Pharma and Bio Sciences
Volume4
Issue number4
Publication statusPublished - 01-10-2013

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Vitamin D Deficiency
Hypothyroidism
Vitamin D
Immune System Diseases
Thyroid Hormones
Cross-Sectional Studies
Neoplasms
Plasmas

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

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title = "Prevalence of vitamin D deficiency and its relationship with subclinical hypothyroidism",
abstract = "Vitamin D deficiency has been implicated in various diseases including cancer and auto immune diseases. The present study attempts to establish a relation between vitamin D deficiency, thyroid hormones and TSH in subclinical hypothyroidism.100 newly diagnosed patients with subclinical hypothyroidism were divided into three groups according to vitamin D levels. Mean plasma TSH and T3 values decreased with increasing vitamin D values and T4 increased with increasing vitamin D tertiles. However, intergroup comparison showed no statistically significant changes. In females, negative correlation between vitamin D and TSH was statistically significant (p=0.014).The prevalence of vitamin D deficiency, insufficiency and sufficiency in 100 patients was found to be 38{\%}, 38{\%} and 24{\%}. The study indicates the prevalence of vitamin D deficiency in subclinical hypothyroidism, but further studies are needed to determine whether it is a causative factor in the pathogenesis of the disease or a consequence.",
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AU - Hegde, Anupama

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AU - Kumarchandra, Reshma

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