Preventive role of vitamin E and vitamin C in combination on cadmium induced oxidative stress on rat testis

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Abstract

Cadmium (Cd) is an industrial pollutant that affects the male reproductive system. The purpose of present study was to investigate the protective role of vitamin E & vitamin C on cadmium induced testicular damage. Rats were divided into four groups with 8 rats in each. The Gr. I rats were administered with the single dose of normal saline intraperitoneally. Group II received Vitamin E & Vitamin C orally for 30days.Group III received a single dose of 1mg/kg bw cadmium chloride and Group IV vitamin E and vitamin C for 30 days prior to cadmium administration. After the desired protocol, rats were sacrificed & both the testes were removed for biochemical & histopathological evaluation. In the present study, the level of lipid peroxidation (LPO) was significantly high & GSH & SOD were low in cadmium treated rats compared to normal control. Pre-treatment with vitamin E & C showed a protective effect by decreasing LPO & increasing GSH & SOD level. The morphological changes like atrophy of tubules, edema & decreased spermatogenesis in the testis of rats exposed to cadmium chloride. But, antioxidant showed the normal architecture of the testis. Thus, present study showed that pre-treatment with vitamin E & C combination was beneficial in protecting the testis from cadmium induced toxicity.

Original languageEnglish
Pages (from-to)1999-2002
Number of pages4
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume7
Issue number4
Publication statusPublished - 01-07-2016

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Oxidative stress
Vitamin E
Cadmium
Ascorbic Acid
Testis
Rats
Oxidative Stress
Cadmium Chloride
Lipid Peroxidation
Lipids
Spermatogenesis
Atrophy
Toxicity
Edema
Antioxidants

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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title = "Preventive role of vitamin E and vitamin C in combination on cadmium induced oxidative stress on rat testis",
abstract = "Cadmium (Cd) is an industrial pollutant that affects the male reproductive system. The purpose of present study was to investigate the protective role of vitamin E & vitamin C on cadmium induced testicular damage. Rats were divided into four groups with 8 rats in each. The Gr. I rats were administered with the single dose of normal saline intraperitoneally. Group II received Vitamin E & Vitamin C orally for 30days.Group III received a single dose of 1mg/kg bw cadmium chloride and Group IV vitamin E and vitamin C for 30 days prior to cadmium administration. After the desired protocol, rats were sacrificed & both the testes were removed for biochemical & histopathological evaluation. In the present study, the level of lipid peroxidation (LPO) was significantly high & GSH & SOD were low in cadmium treated rats compared to normal control. Pre-treatment with vitamin E & C showed a protective effect by decreasing LPO & increasing GSH & SOD level. The morphological changes like atrophy of tubules, edema & decreased spermatogenesis in the testis of rats exposed to cadmium chloride. But, antioxidant showed the normal architecture of the testis. Thus, present study showed that pre-treatment with vitamin E & C combination was beneficial in protecting the testis from cadmium induced toxicity.",
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T1 - Preventive role of vitamin E and vitamin C in combination on cadmium induced oxidative stress on rat testis

AU - Kini, Rekha D.

AU - Kumar, Nayanatara Arun

AU - Anupama, N.

AU - Bhagyalakshmi, K.

AU - Shetty, B. Sneha

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Cadmium (Cd) is an industrial pollutant that affects the male reproductive system. The purpose of present study was to investigate the protective role of vitamin E & vitamin C on cadmium induced testicular damage. Rats were divided into four groups with 8 rats in each. The Gr. I rats were administered with the single dose of normal saline intraperitoneally. Group II received Vitamin E & Vitamin C orally for 30days.Group III received a single dose of 1mg/kg bw cadmium chloride and Group IV vitamin E and vitamin C for 30 days prior to cadmium administration. After the desired protocol, rats were sacrificed & both the testes were removed for biochemical & histopathological evaluation. In the present study, the level of lipid peroxidation (LPO) was significantly high & GSH & SOD were low in cadmium treated rats compared to normal control. Pre-treatment with vitamin E & C showed a protective effect by decreasing LPO & increasing GSH & SOD level. The morphological changes like atrophy of tubules, edema & decreased spermatogenesis in the testis of rats exposed to cadmium chloride. But, antioxidant showed the normal architecture of the testis. Thus, present study showed that pre-treatment with vitamin E & C combination was beneficial in protecting the testis from cadmium induced toxicity.

AB - Cadmium (Cd) is an industrial pollutant that affects the male reproductive system. The purpose of present study was to investigate the protective role of vitamin E & vitamin C on cadmium induced testicular damage. Rats were divided into four groups with 8 rats in each. The Gr. I rats were administered with the single dose of normal saline intraperitoneally. Group II received Vitamin E & Vitamin C orally for 30days.Group III received a single dose of 1mg/kg bw cadmium chloride and Group IV vitamin E and vitamin C for 30 days prior to cadmium administration. After the desired protocol, rats were sacrificed & both the testes were removed for biochemical & histopathological evaluation. In the present study, the level of lipid peroxidation (LPO) was significantly high & GSH & SOD were low in cadmium treated rats compared to normal control. Pre-treatment with vitamin E & C showed a protective effect by decreasing LPO & increasing GSH & SOD level. The morphological changes like atrophy of tubules, edema & decreased spermatogenesis in the testis of rats exposed to cadmium chloride. But, antioxidant showed the normal architecture of the testis. Thus, present study showed that pre-treatment with vitamin E & C combination was beneficial in protecting the testis from cadmium induced toxicity.

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