Pro-healing effects of morin, a natural antioxidant, on normal and dexamethasone-impaired wounds

Rekha Raghuveer Shenoy, Arun Theerthahalli Sudheendra, Pawan Ganesh Nayak, Piya Paul, Nampurath Gopalan Kutty, Chamallamudi Mallikarjuna Rao

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: The aim of the study was to investigate the effects of morin on skin breaking strength, hydroxyproline, lysyl oxidase, DNA and RNA content of experimentally infl icted wounds in rats. Methods: This study was performed on albino rats of either sex at the Central Animal Research Facility (CARF), Manipal University. Results: Morin showed signifi cant wound contraction on day 7 as compared to control with mean closure of 47.44 ± 6.07 % in excision wound model. Granulation tissue breaking strength was signifi cantly increased (p < 0.05) in the morin treated group with 180.2 ± 7.94 g when compared to control at 151.2 ± 6.99 g. There was a signifi cant increase in hydroxyproline content with the morin treated group when compared to control with 3.41 ± 0.33 μ g/mg of granulation tissue. Similarly, the wound parameters were improved with the morin treated group in dexamethasone delayed healing. Conclusions: Our results suggest that morin treatment accelerates the healing process delayed by concurrent use of steroids.

Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalJournal of Basic and Clinical Physiology and Pharmacology
Volume22
Issue number4
DOIs
Publication statusPublished - 12-2011

Fingerprint

Dexamethasone
Antioxidants
Wounds and Injuries
Granulation Tissue
Protein-Lysine 6-Oxidase
Hydroxyproline
morin
Steroids
RNA
Skin
DNA

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Physiology

Cite this

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title = "Pro-healing effects of morin, a natural antioxidant, on normal and dexamethasone-impaired wounds",
abstract = "Background: The aim of the study was to investigate the effects of morin on skin breaking strength, hydroxyproline, lysyl oxidase, DNA and RNA content of experimentally infl icted wounds in rats. Methods: This study was performed on albino rats of either sex at the Central Animal Research Facility (CARF), Manipal University. Results: Morin showed signifi cant wound contraction on day 7 as compared to control with mean closure of 47.44 ± 6.07 {\%} in excision wound model. Granulation tissue breaking strength was signifi cantly increased (p < 0.05) in the morin treated group with 180.2 ± 7.94 g when compared to control at 151.2 ± 6.99 g. There was a signifi cant increase in hydroxyproline content with the morin treated group when compared to control with 3.41 ± 0.33 μ g/mg of granulation tissue. Similarly, the wound parameters were improved with the morin treated group in dexamethasone delayed healing. Conclusions: Our results suggest that morin treatment accelerates the healing process delayed by concurrent use of steroids.",
author = "Shenoy, {Rekha Raghuveer} and Sudheendra, {Arun Theerthahalli} and Nayak, {Pawan Ganesh} and Piya Paul and Kutty, {Nampurath Gopalan} and Rao, {Chamallamudi Mallikarjuna}",
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Pro-healing effects of morin, a natural antioxidant, on normal and dexamethasone-impaired wounds. / Shenoy, Rekha Raghuveer; Sudheendra, Arun Theerthahalli; Nayak, Pawan Ganesh; Paul, Piya; Kutty, Nampurath Gopalan; Rao, Chamallamudi Mallikarjuna.

In: Journal of Basic and Clinical Physiology and Pharmacology, Vol. 22, No. 4, 12.2011, p. 131-135.

Research output: Contribution to journalArticle

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AU - Shenoy, Rekha Raghuveer

AU - Sudheendra, Arun Theerthahalli

AU - Nayak, Pawan Ganesh

AU - Paul, Piya

AU - Kutty, Nampurath Gopalan

AU - Rao, Chamallamudi Mallikarjuna

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Y1 - 2011/12

N2 - Background: The aim of the study was to investigate the effects of morin on skin breaking strength, hydroxyproline, lysyl oxidase, DNA and RNA content of experimentally infl icted wounds in rats. Methods: This study was performed on albino rats of either sex at the Central Animal Research Facility (CARF), Manipal University. Results: Morin showed signifi cant wound contraction on day 7 as compared to control with mean closure of 47.44 ± 6.07 % in excision wound model. Granulation tissue breaking strength was signifi cantly increased (p < 0.05) in the morin treated group with 180.2 ± 7.94 g when compared to control at 151.2 ± 6.99 g. There was a signifi cant increase in hydroxyproline content with the morin treated group when compared to control with 3.41 ± 0.33 μ g/mg of granulation tissue. Similarly, the wound parameters were improved with the morin treated group in dexamethasone delayed healing. Conclusions: Our results suggest that morin treatment accelerates the healing process delayed by concurrent use of steroids.

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