Pro-healing effects of morin, a natural antioxidant, on normal and dexamethasone-impaired wounds

Rekha Raghuveer Shenoy, Arun Theerthahalli Sudheendra, Pawan Ganesh Nayak, Piya Paul, Nampurath Gopalan Kutty, Chamallamudi Mallikarjuna Rao

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Abstract

Background: The aim of the study was to investigate the effects of morin on skin breaking strength, hydroxyproline, lysyl oxidase, DNA and RNA content of experimentally infl icted wounds in rats. Methods: This study was performed on albino rats of either sex at the Central Animal Research Facility (CARF), Manipal University. Results: Morin showed signifi cant wound contraction on day 7 as compared to control with mean closure of 47.44 ± 6.07 % in excision wound model. Granulation tissue breaking strength was signifi cantly increased (p < 0.05) in the morin treated group with 180.2 ± 7.94 g when compared to control at 151.2 ± 6.99 g. There was a signifi cant increase in hydroxyproline content with the morin treated group when compared to control with 3.41 ± 0.33 μ g/mg of granulation tissue. Similarly, the wound parameters were improved with the morin treated group in dexamethasone delayed healing. Conclusions: Our results suggest that morin treatment accelerates the healing process delayed by concurrent use of steroids.

Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalJournal of Basic and Clinical Physiology and Pharmacology
Volume22
Issue number4
DOIs
Publication statusPublished - 12-2011

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Physiology

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