Abstract

Deregulated miR-379/miR-656 cluster expression is considered as important for carcinogenesis and can be used as a potential prognostic marker. Hence, the meta-analysis was conducted to test the utility of miR-379/miR-656 cluster as a prognostic marker in various cancers. A literature search was performed using Web of Science, PubMed and Cochrane Library to obtain relevant studies and were subjected to various subgroup and bioinformatics analyses. Selected twenty-three studies contained 13 cancer types comprising of 3294 patients from 7 nations. Univariate and multivariate data showed an association of high expression of miRNAs with the poor prognosis of cancer patients (p < 0.001). The subgroup analysis showed that lung cancer, breast cancer and papillary renal cell carcinoma (p < 0.001) have a negative association with the survival of patients. Our study is the first meta-analysis showing the association of miR-379/miR-656 cluster expression and overall survival, suggesting its potential as a prognostic indicator in multiple cancers.

Original languageEnglish
JournalClinical and Experimental Metastasis
DOIs
Publication statusAccepted/In press - 01-01-2019

Fingerprint

MicroRNAs
Meta-Analysis
Carcinoma
Neoplasms
Breast Neoplasms
Survival
Computational Biology
Renal Cell Carcinoma
PubMed
Libraries
Lung Neoplasms
Carcinogenesis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

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title = "Prognostic role of 14q32.31 miRNA cluster in various carcinomas: a systematic review and meta-analysis",
abstract = "Deregulated miR-379/miR-656 cluster expression is considered as important for carcinogenesis and can be used as a potential prognostic marker. Hence, the meta-analysis was conducted to test the utility of miR-379/miR-656 cluster as a prognostic marker in various cancers. A literature search was performed using Web of Science, PubMed and Cochrane Library to obtain relevant studies and were subjected to various subgroup and bioinformatics analyses. Selected twenty-three studies contained 13 cancer types comprising of 3294 patients from 7 nations. Univariate and multivariate data showed an association of high expression of miRNAs with the poor prognosis of cancer patients (p < 0.001). The subgroup analysis showed that lung cancer, breast cancer and papillary renal cell carcinoma (p < 0.001) have a negative association with the survival of patients. Our study is the first meta-analysis showing the association of miR-379/miR-656 cluster expression and overall survival, suggesting its potential as a prognostic indicator in multiple cancers.",
author = "Jishnu, {Padacherri Vethil} and Pradyumna Jayaram and Vaibhav Shukla and Varghese, {Vinay Koshy} and Deeksha Pandey and Krishna Sharan and Sanjiban Chakrabarty and Kapaettu Satyamoorthy and Kabekkodu, {Shama Prasada}",
year = "2019",
month = "1",
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doi = "10.1007/s10585-019-10013-2",
language = "English",
journal = "Clinical and Experimental Metastasis",
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}

Prognostic role of 14q32.31 miRNA cluster in various carcinomas : a systematic review and meta-analysis. / Jishnu, Padacherri Vethil; Jayaram, Pradyumna; Shukla, Vaibhav; Varghese, Vinay Koshy; Pandey, Deeksha; Sharan, Krishna; Chakrabarty, Sanjiban; Satyamoorthy, Kapaettu; Kabekkodu, Shama Prasada.

In: Clinical and Experimental Metastasis, 01.01.2019.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Prognostic role of 14q32.31 miRNA cluster in various carcinomas

T2 - a systematic review and meta-analysis

AU - Jishnu, Padacherri Vethil

AU - Jayaram, Pradyumna

AU - Shukla, Vaibhav

AU - Varghese, Vinay Koshy

AU - Pandey, Deeksha

AU - Sharan, Krishna

AU - Chakrabarty, Sanjiban

AU - Satyamoorthy, Kapaettu

AU - Kabekkodu, Shama Prasada

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Deregulated miR-379/miR-656 cluster expression is considered as important for carcinogenesis and can be used as a potential prognostic marker. Hence, the meta-analysis was conducted to test the utility of miR-379/miR-656 cluster as a prognostic marker in various cancers. A literature search was performed using Web of Science, PubMed and Cochrane Library to obtain relevant studies and were subjected to various subgroup and bioinformatics analyses. Selected twenty-three studies contained 13 cancer types comprising of 3294 patients from 7 nations. Univariate and multivariate data showed an association of high expression of miRNAs with the poor prognosis of cancer patients (p < 0.001). The subgroup analysis showed that lung cancer, breast cancer and papillary renal cell carcinoma (p < 0.001) have a negative association with the survival of patients. Our study is the first meta-analysis showing the association of miR-379/miR-656 cluster expression and overall survival, suggesting its potential as a prognostic indicator in multiple cancers.

AB - Deregulated miR-379/miR-656 cluster expression is considered as important for carcinogenesis and can be used as a potential prognostic marker. Hence, the meta-analysis was conducted to test the utility of miR-379/miR-656 cluster as a prognostic marker in various cancers. A literature search was performed using Web of Science, PubMed and Cochrane Library to obtain relevant studies and were subjected to various subgroup and bioinformatics analyses. Selected twenty-three studies contained 13 cancer types comprising of 3294 patients from 7 nations. Univariate and multivariate data showed an association of high expression of miRNAs with the poor prognosis of cancer patients (p < 0.001). The subgroup analysis showed that lung cancer, breast cancer and papillary renal cell carcinoma (p < 0.001) have a negative association with the survival of patients. Our study is the first meta-analysis showing the association of miR-379/miR-656 cluster expression and overall survival, suggesting its potential as a prognostic indicator in multiple cancers.

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