Abstract

Background: Little data exist on the progression of recurrent acute (RAP) and chronic pancreatitis (CP) from regions from where the entity of tropical chronic pancreatitis was originally described. The study aimed to follow up patients with RAP and CP seen at a southern Indian centre for progression of disease over time. Methods: Prospectively enrolled patients with RAP and CP were followed up, and the alcoholic and idiopathic subgroups were assessed for progression of structural and functional changes in the organ. Results: One hundred and forty patients (RAP = 44; 31.4 %, CP = 96; 68.5 %) were followed up over a median 12.2 (interquartile range 12.0–16.8) months. The cause was alcohol in 31 (22.1 %) and not evident in 109 (77.8 %). The disease progressed from RAP to CP in 7 (15.9 %), 6 (16.2 %) out of 37 in the idiopathic and 1 (14.2 %; p = 1.00) out of 7 in the alcoholic subgroups. Three (42.8 %) and 1 (14.2 %) developed steatorrhea and diabetes mellitus (DM), respectively, and 2 (4.5 %) developed calcification. Established CP progressed in 19 (19.7 %), 1 (1.0 %), 5 (5.2 %), 2 (2.0 %) and 11 (11.4 %) newly developed DM, steatorrhea, calcification and duct dilation during follow up. Among the idiopathic and alcoholic CP, disease progression was seen in 15 (20.8 %) out of 72 and 4 (16.6 %) out of 24 respectively. Conclusions: Idiopathic RAP and CP progressed during the short-term follow up. This is similar to other etiological forms of pancreatitis, as described from elsewhere in the world.

Original languageEnglish
Pages (from-to)425-431
Number of pages7
JournalIndian Journal of Gastroenterology
Volume35
Issue number6
DOIs
Publication statusPublished - 01-11-2016

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Chronic Pancreatitis
Steatorrhea
Disease Progression
Diabetes Mellitus
Alcoholic Pancreatitis
Alcoholics
Pancreatitis
Dilatation
Chronic Disease
Alcohols

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

@article{553a5c15ac1c4847bf364eca6dbb5882,
title = "Progression of recurrent acute and chronic pancreatitis: A short-term follow up study from a southern Indian centre",
abstract = "Background: Little data exist on the progression of recurrent acute (RAP) and chronic pancreatitis (CP) from regions from where the entity of tropical chronic pancreatitis was originally described. The study aimed to follow up patients with RAP and CP seen at a southern Indian centre for progression of disease over time. Methods: Prospectively enrolled patients with RAP and CP were followed up, and the alcoholic and idiopathic subgroups were assessed for progression of structural and functional changes in the organ. Results: One hundred and forty patients (RAP = 44; 31.4 {\%}, CP = 96; 68.5 {\%}) were followed up over a median 12.2 (interquartile range 12.0–16.8) months. The cause was alcohol in 31 (22.1 {\%}) and not evident in 109 (77.8 {\%}). The disease progressed from RAP to CP in 7 (15.9 {\%}), 6 (16.2 {\%}) out of 37 in the idiopathic and 1 (14.2 {\%}; p = 1.00) out of 7 in the alcoholic subgroups. Three (42.8 {\%}) and 1 (14.2 {\%}) developed steatorrhea and diabetes mellitus (DM), respectively, and 2 (4.5 {\%}) developed calcification. Established CP progressed in 19 (19.7 {\%}), 1 (1.0 {\%}), 5 (5.2 {\%}), 2 (2.0 {\%}) and 11 (11.4 {\%}) newly developed DM, steatorrhea, calcification and duct dilation during follow up. Among the idiopathic and alcoholic CP, disease progression was seen in 15 (20.8 {\%}) out of 72 and 4 (16.6 {\%}) out of 24 respectively. Conclusions: Idiopathic RAP and CP progressed during the short-term follow up. This is similar to other etiological forms of pancreatitis, as described from elsewhere in the world.",
author = "Kamath, {M. Ganesh} and Pai, {C. Ganesh} and Asha Kamath",
year = "2016",
month = "11",
day = "1",
doi = "10.1007/s12664-016-0700-x",
language = "English",
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pages = "425--431",
journal = "Indian Journal of Gastroenterology",
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number = "6",

}

TY - JOUR

T1 - Progression of recurrent acute and chronic pancreatitis

T2 - A short-term follow up study from a southern Indian centre

AU - Kamath, M. Ganesh

AU - Pai, C. Ganesh

AU - Kamath, Asha

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Background: Little data exist on the progression of recurrent acute (RAP) and chronic pancreatitis (CP) from regions from where the entity of tropical chronic pancreatitis was originally described. The study aimed to follow up patients with RAP and CP seen at a southern Indian centre for progression of disease over time. Methods: Prospectively enrolled patients with RAP and CP were followed up, and the alcoholic and idiopathic subgroups were assessed for progression of structural and functional changes in the organ. Results: One hundred and forty patients (RAP = 44; 31.4 %, CP = 96; 68.5 %) were followed up over a median 12.2 (interquartile range 12.0–16.8) months. The cause was alcohol in 31 (22.1 %) and not evident in 109 (77.8 %). The disease progressed from RAP to CP in 7 (15.9 %), 6 (16.2 %) out of 37 in the idiopathic and 1 (14.2 %; p = 1.00) out of 7 in the alcoholic subgroups. Three (42.8 %) and 1 (14.2 %) developed steatorrhea and diabetes mellitus (DM), respectively, and 2 (4.5 %) developed calcification. Established CP progressed in 19 (19.7 %), 1 (1.0 %), 5 (5.2 %), 2 (2.0 %) and 11 (11.4 %) newly developed DM, steatorrhea, calcification and duct dilation during follow up. Among the idiopathic and alcoholic CP, disease progression was seen in 15 (20.8 %) out of 72 and 4 (16.6 %) out of 24 respectively. Conclusions: Idiopathic RAP and CP progressed during the short-term follow up. This is similar to other etiological forms of pancreatitis, as described from elsewhere in the world.

AB - Background: Little data exist on the progression of recurrent acute (RAP) and chronic pancreatitis (CP) from regions from where the entity of tropical chronic pancreatitis was originally described. The study aimed to follow up patients with RAP and CP seen at a southern Indian centre for progression of disease over time. Methods: Prospectively enrolled patients with RAP and CP were followed up, and the alcoholic and idiopathic subgroups were assessed for progression of structural and functional changes in the organ. Results: One hundred and forty patients (RAP = 44; 31.4 %, CP = 96; 68.5 %) were followed up over a median 12.2 (interquartile range 12.0–16.8) months. The cause was alcohol in 31 (22.1 %) and not evident in 109 (77.8 %). The disease progressed from RAP to CP in 7 (15.9 %), 6 (16.2 %) out of 37 in the idiopathic and 1 (14.2 %; p = 1.00) out of 7 in the alcoholic subgroups. Three (42.8 %) and 1 (14.2 %) developed steatorrhea and diabetes mellitus (DM), respectively, and 2 (4.5 %) developed calcification. Established CP progressed in 19 (19.7 %), 1 (1.0 %), 5 (5.2 %), 2 (2.0 %) and 11 (11.4 %) newly developed DM, steatorrhea, calcification and duct dilation during follow up. Among the idiopathic and alcoholic CP, disease progression was seen in 15 (20.8 %) out of 72 and 4 (16.6 %) out of 24 respectively. Conclusions: Idiopathic RAP and CP progressed during the short-term follow up. This is similar to other etiological forms of pancreatitis, as described from elsewhere in the world.

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U2 - 10.1007/s12664-016-0700-x

DO - 10.1007/s12664-016-0700-x

M3 - Article

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AN - SCOPUS:84992425360

VL - 35

SP - 425

EP - 431

JO - Indian Journal of Gastroenterology

JF - Indian Journal of Gastroenterology

SN - 0254-8860

IS - 6

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