Proniosomes as a novel drug carrier for the delivery of ketoprofen

P. Aneesha, M. Vivek Ghate, Reema Narayan, Shajan Abraham

Research output: Contribution to journalArticle

Abstract

Nanotechnology is an advancing technology expected to bring revolutionary changes in the field of life sciences including drug delivery, diagnostics, neutraceuticals and biomedicals for implants and prosthesis. One of the advancement in nanotechnology is the preparation of proniosomes derived niosomes. Proniosomes are solid colloidal particles which may be hydrated immediately before use to yield aqueous niosomal dispersions similar to those produced by conventional methods. These ‘proniosomes’ minimize problems of niosomes physical stability such as aggregation, fusion and leaking and provide additional convenience in transportation, distribution, storage, and dosing. Ketoprofen loaded maltodextrin based proniosomes were prepared by slurry method with different surfactant to cholesterol ratio. The proniosome formulations were evaluated for flow property, morphological and size analysis studies. The niosomal suspensions were further evaluated for entrapment efficiency, in vitro release study, kinetic data analysis and stability study. The result from SEM analysis has confirmed the coating of surfactant on the surface of carrier. The formulation F4 which showed higher entrapment efficiency of 82.64% and in vitro release of 90.4% at the end of 12 hr was found to be best among the all 7 formulation. Release was best explained by the zero order kinetics. Kinetic analysis shows that the drug release follows super case II transport diffusion. Proniosome formulation has showed appropriate stability for six months when compared with reconstituted niosomes by storing the formulation at accelerated condition.

Original languageEnglish
Pages (from-to)1858-1863
Number of pages6
JournalAdvanced Science Letters
Volume23
Issue number3
DOIs
Publication statusPublished - 01-03-2017
Externally publishedYes

Fingerprint

Ketoprofen
Drug Carriers
Liposomes
Drugs
Nanotechnology
drug
nanotechnology
Surface-Active Agents
kinetics
Kinetics
surfactant
Formulation
Surface active agents
Surfactant
efficiency
life science
Biological Science Disciplines
life sciences
Cholesterol
Dietary Supplements

All Science Journal Classification (ASJC) codes

  • Health(social science)
  • Computer Science(all)
  • Education
  • Mathematics(all)
  • Environmental Science(all)
  • Engineering(all)
  • Energy(all)

Cite this

Aneesha, P. ; Ghate, M. Vivek ; Narayan, Reema ; Abraham, Shajan. / Proniosomes as a novel drug carrier for the delivery of ketoprofen. In: Advanced Science Letters. 2017 ; Vol. 23, No. 3. pp. 1858-1863.
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Aneesha, P, Ghate, MV, Narayan, R & Abraham, S 2017, 'Proniosomes as a novel drug carrier for the delivery of ketoprofen', Advanced Science Letters, vol. 23, no. 3, pp. 1858-1863. https://doi.org/10.1166/asl.2017.8496

Proniosomes as a novel drug carrier for the delivery of ketoprofen. / Aneesha, P.; Ghate, M. Vivek; Narayan, Reema; Abraham, Shajan.

In: Advanced Science Letters, Vol. 23, No. 3, 01.03.2017, p. 1858-1863.

Research output: Contribution to journalArticle

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