Prospective randomized controlled trial to compare 3-dimensional conformal radiotherapy to intensity-modulated radiotherapy in head and neck squamous cell carcinoma: Long-term results

Sarbani Ghosh-Laskar, Prahlad H. Yathiraj, Debnarayana Dutta, Venkatesh Rangarajan, Nilendu Purandare, Tejpal Gupta, Ashwini Budrukkar, Vedang Murthy, Sadhana Kannan, Jai Prakash Agarwal

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background Grade ≥2 acute xerostomia between 3D conformal radiotherapy (RT) and intensity-modulated radiotherapy (IMRT) was evaluated in patients with head and neck squamous cell carcinomas (HNSCCs) treated radically. Methods Between 2005 and 2007, 59 patients with HNSCC (T1-3, N0-2b) were randomized to IMRT or 3D-RT. On RT, weekly xerostomia, dysphagia, dermatitis, and mucositis were graded by Radiation Therapy Oncology Group (RTOG) acute toxicity criteria. Patients underwent examination under anesthesia, positron emission tomography (PET)-CT, and toxicity assessments per protocol (NCT00652613) thereafter. Results Incidence of grade ≥2 xerostomia at 8 weeks posttreatment was significantly lower with IMRT compared with 3D conformal RT (24% vs 53%; p =.024). At subsequent follow-up, significantly fewer patients receiving IMRT had grade ≥2 xerostomia. Long-term weight loss was higher in patients in the 3D conformal RT arm compared to IMRT (50% vs 21%; p =.038). Disease-related outcomes between arms (median follow-up, 70 months) were similar. Conclusion IMRT significantly reduces incidence of acute and late grade ≥2 xerostomia in patients with HNSCC.

Original languageEnglish
Pages (from-to)E1481-E1487
JournalHead and Neck
Volume38
DOIs
Publication statusPublished - 01-04-2016

Fingerprint

Conformal Radiotherapy
Intensity-Modulated Radiotherapy
Xerostomia
Randomized Controlled Trials
Radiotherapy
Mucositis
Radiation Oncology
Incidence
Dermatitis
Deglutition Disorders
Positron-Emission Tomography
Carcinoma, squamous cell of head and neck
Weight Loss
Anesthesia

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Ghosh-Laskar, Sarbani ; Yathiraj, Prahlad H. ; Dutta, Debnarayana ; Rangarajan, Venkatesh ; Purandare, Nilendu ; Gupta, Tejpal ; Budrukkar, Ashwini ; Murthy, Vedang ; Kannan, Sadhana ; Agarwal, Jai Prakash. / Prospective randomized controlled trial to compare 3-dimensional conformal radiotherapy to intensity-modulated radiotherapy in head and neck squamous cell carcinoma : Long-term results. In: Head and Neck. 2016 ; Vol. 38. pp. E1481-E1487.
@article{6964cecf015e4d0aa984a8160ea3c70a,
title = "Prospective randomized controlled trial to compare 3-dimensional conformal radiotherapy to intensity-modulated radiotherapy in head and neck squamous cell carcinoma: Long-term results",
abstract = "Background Grade ≥2 acute xerostomia between 3D conformal radiotherapy (RT) and intensity-modulated radiotherapy (IMRT) was evaluated in patients with head and neck squamous cell carcinomas (HNSCCs) treated radically. Methods Between 2005 and 2007, 59 patients with HNSCC (T1-3, N0-2b) were randomized to IMRT or 3D-RT. On RT, weekly xerostomia, dysphagia, dermatitis, and mucositis were graded by Radiation Therapy Oncology Group (RTOG) acute toxicity criteria. Patients underwent examination under anesthesia, positron emission tomography (PET)-CT, and toxicity assessments per protocol (NCT00652613) thereafter. Results Incidence of grade ≥2 xerostomia at 8 weeks posttreatment was significantly lower with IMRT compared with 3D conformal RT (24{\%} vs 53{\%}; p =.024). At subsequent follow-up, significantly fewer patients receiving IMRT had grade ≥2 xerostomia. Long-term weight loss was higher in patients in the 3D conformal RT arm compared to IMRT (50{\%} vs 21{\%}; p =.038). Disease-related outcomes between arms (median follow-up, 70 months) were similar. Conclusion IMRT significantly reduces incidence of acute and late grade ≥2 xerostomia in patients with HNSCC.",
author = "Sarbani Ghosh-Laskar and Yathiraj, {Prahlad H.} and Debnarayana Dutta and Venkatesh Rangarajan and Nilendu Purandare and Tejpal Gupta and Ashwini Budrukkar and Vedang Murthy and Sadhana Kannan and Agarwal, {Jai Prakash}",
year = "2016",
month = "4",
day = "1",
doi = "10.1002/hed.24263",
language = "English",
volume = "38",
pages = "E1481--E1487",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "John Wiley and Sons Inc.",

}

Prospective randomized controlled trial to compare 3-dimensional conformal radiotherapy to intensity-modulated radiotherapy in head and neck squamous cell carcinoma : Long-term results. / Ghosh-Laskar, Sarbani; Yathiraj, Prahlad H.; Dutta, Debnarayana; Rangarajan, Venkatesh; Purandare, Nilendu; Gupta, Tejpal; Budrukkar, Ashwini; Murthy, Vedang; Kannan, Sadhana; Agarwal, Jai Prakash.

In: Head and Neck, Vol. 38, 01.04.2016, p. E1481-E1487.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prospective randomized controlled trial to compare 3-dimensional conformal radiotherapy to intensity-modulated radiotherapy in head and neck squamous cell carcinoma

T2 - Long-term results

AU - Ghosh-Laskar, Sarbani

AU - Yathiraj, Prahlad H.

AU - Dutta, Debnarayana

AU - Rangarajan, Venkatesh

AU - Purandare, Nilendu

AU - Gupta, Tejpal

AU - Budrukkar, Ashwini

AU - Murthy, Vedang

AU - Kannan, Sadhana

AU - Agarwal, Jai Prakash

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background Grade ≥2 acute xerostomia between 3D conformal radiotherapy (RT) and intensity-modulated radiotherapy (IMRT) was evaluated in patients with head and neck squamous cell carcinomas (HNSCCs) treated radically. Methods Between 2005 and 2007, 59 patients with HNSCC (T1-3, N0-2b) were randomized to IMRT or 3D-RT. On RT, weekly xerostomia, dysphagia, dermatitis, and mucositis were graded by Radiation Therapy Oncology Group (RTOG) acute toxicity criteria. Patients underwent examination under anesthesia, positron emission tomography (PET)-CT, and toxicity assessments per protocol (NCT00652613) thereafter. Results Incidence of grade ≥2 xerostomia at 8 weeks posttreatment was significantly lower with IMRT compared with 3D conformal RT (24% vs 53%; p =.024). At subsequent follow-up, significantly fewer patients receiving IMRT had grade ≥2 xerostomia. Long-term weight loss was higher in patients in the 3D conformal RT arm compared to IMRT (50% vs 21%; p =.038). Disease-related outcomes between arms (median follow-up, 70 months) were similar. Conclusion IMRT significantly reduces incidence of acute and late grade ≥2 xerostomia in patients with HNSCC.

AB - Background Grade ≥2 acute xerostomia between 3D conformal radiotherapy (RT) and intensity-modulated radiotherapy (IMRT) was evaluated in patients with head and neck squamous cell carcinomas (HNSCCs) treated radically. Methods Between 2005 and 2007, 59 patients with HNSCC (T1-3, N0-2b) were randomized to IMRT or 3D-RT. On RT, weekly xerostomia, dysphagia, dermatitis, and mucositis were graded by Radiation Therapy Oncology Group (RTOG) acute toxicity criteria. Patients underwent examination under anesthesia, positron emission tomography (PET)-CT, and toxicity assessments per protocol (NCT00652613) thereafter. Results Incidence of grade ≥2 xerostomia at 8 weeks posttreatment was significantly lower with IMRT compared with 3D conformal RT (24% vs 53%; p =.024). At subsequent follow-up, significantly fewer patients receiving IMRT had grade ≥2 xerostomia. Long-term weight loss was higher in patients in the 3D conformal RT arm compared to IMRT (50% vs 21%; p =.038). Disease-related outcomes between arms (median follow-up, 70 months) were similar. Conclusion IMRT significantly reduces incidence of acute and late grade ≥2 xerostomia in patients with HNSCC.

UR - http://www.scopus.com/inward/record.url?scp=84948163636&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948163636&partnerID=8YFLogxK

U2 - 10.1002/hed.24263

DO - 10.1002/hed.24263

M3 - Article

C2 - 26561342

AN - SCOPUS:84948163636

VL - 38

SP - E1481-E1487

JO - Head and Neck

JF - Head and Neck

SN - 1043-3074

ER -