Protection of cyclophosphamide induced myelosuppression by alcoholic extract of pimenta dioica leaves in mice

Yogendra Nayak; D. Abhilash

Protection of cyclophosphamide induced myelosuppression by alcoholic extract of pimenta dioica leaves in mice

Research output: Contribution to journal › Article › peer-review

Abstract

The leaves of Pimenta dioica (L) Merril (Fam: Myrtaceae) were used as medicine for pain, arthritis, fever and stress in the folklore medicine at Kerala and Mangalore. The berries are commonly known as Allspice in culinary natives of Kerala and Mangalore. The high total phenolic content in the berries and leaves were reported for antioxidant activity: In the present study we tried the alcoholic extract of leaves for protection in cyclophospamide induced myelosuppression in Swiss mice. The oral doses (250, 500, 750 mg/kg/day) showed statistically significant protection of myelosuppression.

Original language	English
Pages (from-to)	719-723
Number of pages	5
Journal	Pharmacologyonline
Volume	3
Publication status	Published - 2008

All Science Journal Classification (ASJC) codes

Drug Discovery
Pharmacology

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title = "Protection of cyclophosphamide induced myelosuppression by alcoholic extract of pimenta dioica leaves in mice",

abstract = "The leaves of Pimenta dioica (L) Merril (Fam: Myrtaceae) were used as medicine for pain, arthritis, fever and stress in the folklore medicine at Kerala and Mangalore. The berries are commonly known as Allspice in culinary natives of Kerala and Mangalore. The high total phenolic content in the berries and leaves were reported for antioxidant activity: In the present study we tried the alcoholic extract of leaves for protection in cyclophospamide induced myelosuppression in Swiss mice. The oral doses (250, 500, 750 mg/kg/day) showed statistically significant protection of myelosuppression.",

author = "Yogendra Nayak and D. Abhilash",

year = "2008",

language = "English",

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pages = "719--723",

journal = "Pharmacologyonline",

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AU - Nayak, Yogendra

AU - Abhilash, D.

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N2 - The leaves of Pimenta dioica (L) Merril (Fam: Myrtaceae) were used as medicine for pain, arthritis, fever and stress in the folklore medicine at Kerala and Mangalore. The berries are commonly known as Allspice in culinary natives of Kerala and Mangalore. The high total phenolic content in the berries and leaves were reported for antioxidant activity: In the present study we tried the alcoholic extract of leaves for protection in cyclophospamide induced myelosuppression in Swiss mice. The oral doses (250, 500, 750 mg/kg/day) showed statistically significant protection of myelosuppression.

AB - The leaves of Pimenta dioica (L) Merril (Fam: Myrtaceae) were used as medicine for pain, arthritis, fever and stress in the folklore medicine at Kerala and Mangalore. The berries are commonly known as Allspice in culinary natives of Kerala and Mangalore. The high total phenolic content in the berries and leaves were reported for antioxidant activity: In the present study we tried the alcoholic extract of leaves for protection in cyclophospamide induced myelosuppression in Swiss mice. The oral doses (250, 500, 750 mg/kg/day) showed statistically significant protection of myelosuppression.

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