Protection of cyclophosphamide induced myelosuppression by alcoholic extract of pimenta dioica leaves in mice

Yogendra Nayak, D. Abhilash

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4 Citations (Scopus)

Abstract

The leaves of Pimenta dioica (L) Merril (Fam: Myrtaceae) were used as medicine for pain, arthritis, fever and stress in the folklore medicine at Kerala and Mangalore. The berries are commonly known as Allspice in culinary natives of Kerala and Mangalore. The high total phenolic content in the berries and leaves were reported for antioxidant activity: In the present study we tried the alcoholic extract of leaves for protection in cyclophospamide induced myelosuppression in Swiss mice. The oral doses (250, 500, 750 mg/kg/day) showed statistically significant protection of myelosuppression.

Original languageEnglish
Pages (from-to)719-723
Number of pages5
JournalPharmacologyonline
Volume3
Publication statusPublished - 2008

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All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Pharmacology

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