Protective effect of ascorbic acid and Ginkgo biloba against learning and memory deficits caused by fluoride

Raghu Jetti, Cv Raghuveer, Mallikarjuna C Rao

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Fluoride is present in the ground water, World Health Organization permitted level of fluoride in the ground water is 0.5 ppm. Tooth pastes, mouth washes, tea and sea fish are the sources of fluoride. Exposure to these multiple sources results in several adverse effects in addition to the fluorosis. The present study aimed to test the effect of vitamin C and Ginkgo biloba against the behavioural deficits caused by fluoride. Rats were divided into five groups with six animals in each group (n = 6). Control group received ordinary tap water with 0.5 ppm of fluoride, the remaining groups received 100 ppm of fluoride for 30 days prior to fluoride exposure. Two groups of animals received 100 mg/kg body weight of vitamin C and G. biloba for 15 days prior to fluoride exposure. After 45 days, behavioural studies (T-Maze, passive avoidance) were conducted on the experimental animals. The results of the present study showed no behavioural deficits in the control group of animals however, the rats that received fluoride water exhibited impairment in their spatial learning and memory deficits. The deficits are not marked in the vitamin C and G. biloba groups. To conclude chronic exposure to high levels of fluoride causes severe impairment in the spatial learning and memory, these deficits can be ameliorated with the vitamin C and G. biloba.

Original languageEnglish
Pages (from-to)183-187
Number of pages5
JournalToxicology and Industrial Health
Volume32
Issue number1
DOIs
Publication statusPublished - 2016

Fingerprint

Ginkgo biloba
Memory Disorders
Fluorides
Ascorbic Acid
Learning
Data storage equipment
Riboflavin
Animals
Groundwater
Rats
Control Groups
Water
Tea
Ointments
Oceans and Seas
Fish
Mouth
Tooth
Fishes
Body Weight

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

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title = "Protective effect of ascorbic acid and Ginkgo biloba against learning and memory deficits caused by fluoride",
abstract = "Fluoride is present in the ground water, World Health Organization permitted level of fluoride in the ground water is 0.5 ppm. Tooth pastes, mouth washes, tea and sea fish are the sources of fluoride. Exposure to these multiple sources results in several adverse effects in addition to the fluorosis. The present study aimed to test the effect of vitamin C and Ginkgo biloba against the behavioural deficits caused by fluoride. Rats were divided into five groups with six animals in each group (n = 6). Control group received ordinary tap water with 0.5 ppm of fluoride, the remaining groups received 100 ppm of fluoride for 30 days prior to fluoride exposure. Two groups of animals received 100 mg/kg body weight of vitamin C and G. biloba for 15 days prior to fluoride exposure. After 45 days, behavioural studies (T-Maze, passive avoidance) were conducted on the experimental animals. The results of the present study showed no behavioural deficits in the control group of animals however, the rats that received fluoride water exhibited impairment in their spatial learning and memory deficits. The deficits are not marked in the vitamin C and G. biloba groups. To conclude chronic exposure to high levels of fluoride causes severe impairment in the spatial learning and memory, these deficits can be ameliorated with the vitamin C and G. biloba.",
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Protective effect of ascorbic acid and Ginkgo biloba against learning and memory deficits caused by fluoride. / Jetti, Raghu; Raghuveer, Cv; Rao, Mallikarjuna C.

In: Toxicology and Industrial Health, Vol. 32, No. 1, 2016, p. 183-187.

Research output: Contribution to journalArticle

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