Protective effect of metformin against tuberculosis infections in diabetic patients

an observational study of south Indian tertiary healthcare facility

Srujitha Marupuru, Padmanav Senapati, Swathi Pathadka, Sonal Sekhar Miraj, Mazhuvancherry Kesavan Unnikrishnan, Mohan K. Manu

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background World Health Organization estimated that people with diabetes (DM) are at 2–3 times higher risk for tuberculosis (TB). Studies have shown that DM not only increases the risk of active TB, but also puts co-affected persons at increased risk of poor outcomes. Objectives To determine the protective effect of metformin against TB in DM patients and also, to investigate the relationship between poor glycemic control and TB. Methods A case–control study was conducted over 8 months, where cases and controls were selected based on the inclusion and exclusion criteria of the study. The diabetics diagnosed with TB were selected as study group (SG = 152) and without TB were as control group (CG = 299). Exposure status of metformin in both groups were analyzed. Results The mean (SD) age of both CG and SG were 55.54 ± 11.82 and 52.80 ± 11.75, respectively. Majority of the subjects in the study were males. The mean hospital stay of SG and CG were 7 days and 6 days, respectively. Poor glycemic control (HbA1c > 8) observed in SG (51.7%) vs CG (31.4%). HbA1c value <7 is associated protective factor for TB occurrence [OR = 0.52 (95% CI 0.29–0.93)]. The protective effect of metformin against TB was 3.9-fold in diabetics (OR = 0.256, 0.16–0.40). Conclusion Poor glycemic control among diabetics is a risk factor for TB occurrence. The result shows metformin use is a protective agent against TB infection in diabetics. Hence, incorporation of metformin into standard clinical care would offer a therapeutic option for the prevention of TB.

Original languageEnglish
Pages (from-to)312-316
Number of pages5
JournalBrazilian Journal of Infectious Diseases
Volume21
Issue number3
DOIs
Publication statusPublished - 01-05-2017

Fingerprint

Metformin
Tertiary Healthcare
Observational Studies
Tuberculosis
Infection
Protective Agents
Length of Stay

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

@article{ca60b61ff9874ddd97b564bb8b95ea8e,
title = "Protective effect of metformin against tuberculosis infections in diabetic patients: an observational study of south Indian tertiary healthcare facility",
abstract = "Background World Health Organization estimated that people with diabetes (DM) are at 2–3 times higher risk for tuberculosis (TB). Studies have shown that DM not only increases the risk of active TB, but also puts co-affected persons at increased risk of poor outcomes. Objectives To determine the protective effect of metformin against TB in DM patients and also, to investigate the relationship between poor glycemic control and TB. Methods A case–control study was conducted over 8 months, where cases and controls were selected based on the inclusion and exclusion criteria of the study. The diabetics diagnosed with TB were selected as study group (SG = 152) and without TB were as control group (CG = 299). Exposure status of metformin in both groups were analyzed. Results The mean (SD) age of both CG and SG were 55.54 ± 11.82 and 52.80 ± 11.75, respectively. Majority of the subjects in the study were males. The mean hospital stay of SG and CG were 7 days and 6 days, respectively. Poor glycemic control (HbA1c > 8) observed in SG (51.7{\%}) vs CG (31.4{\%}). HbA1c value <7 is associated protective factor for TB occurrence [OR = 0.52 (95{\%} CI 0.29–0.93)]. The protective effect of metformin against TB was 3.9-fold in diabetics (OR = 0.256, 0.16–0.40). Conclusion Poor glycemic control among diabetics is a risk factor for TB occurrence. The result shows metformin use is a protective agent against TB infection in diabetics. Hence, incorporation of metformin into standard clinical care would offer a therapeutic option for the prevention of TB.",
author = "Srujitha Marupuru and Padmanav Senapati and Swathi Pathadka and Miraj, {Sonal Sekhar} and Unnikrishnan, {Mazhuvancherry Kesavan} and Manu, {Mohan K.}",
year = "2017",
month = "5",
day = "1",
doi = "10.1016/j.bjid.2017.01.001",
language = "English",
volume = "21",
pages = "312--316",
journal = "Brazilian Journal of Infectious Diseases",
issn = "1413-8670",
publisher = "Elsevier Editora Ltda",
number = "3",

}

Protective effect of metformin against tuberculosis infections in diabetic patients : an observational study of south Indian tertiary healthcare facility. / Marupuru, Srujitha; Senapati, Padmanav; Pathadka, Swathi; Miraj, Sonal Sekhar; Unnikrishnan, Mazhuvancherry Kesavan; Manu, Mohan K.

In: Brazilian Journal of Infectious Diseases, Vol. 21, No. 3, 01.05.2017, p. 312-316.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Protective effect of metformin against tuberculosis infections in diabetic patients

T2 - an observational study of south Indian tertiary healthcare facility

AU - Marupuru, Srujitha

AU - Senapati, Padmanav

AU - Pathadka, Swathi

AU - Miraj, Sonal Sekhar

AU - Unnikrishnan, Mazhuvancherry Kesavan

AU - Manu, Mohan K.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Background World Health Organization estimated that people with diabetes (DM) are at 2–3 times higher risk for tuberculosis (TB). Studies have shown that DM not only increases the risk of active TB, but also puts co-affected persons at increased risk of poor outcomes. Objectives To determine the protective effect of metformin against TB in DM patients and also, to investigate the relationship between poor glycemic control and TB. Methods A case–control study was conducted over 8 months, where cases and controls were selected based on the inclusion and exclusion criteria of the study. The diabetics diagnosed with TB were selected as study group (SG = 152) and without TB were as control group (CG = 299). Exposure status of metformin in both groups were analyzed. Results The mean (SD) age of both CG and SG were 55.54 ± 11.82 and 52.80 ± 11.75, respectively. Majority of the subjects in the study were males. The mean hospital stay of SG and CG were 7 days and 6 days, respectively. Poor glycemic control (HbA1c > 8) observed in SG (51.7%) vs CG (31.4%). HbA1c value <7 is associated protective factor for TB occurrence [OR = 0.52 (95% CI 0.29–0.93)]. The protective effect of metformin against TB was 3.9-fold in diabetics (OR = 0.256, 0.16–0.40). Conclusion Poor glycemic control among diabetics is a risk factor for TB occurrence. The result shows metformin use is a protective agent against TB infection in diabetics. Hence, incorporation of metformin into standard clinical care would offer a therapeutic option for the prevention of TB.

AB - Background World Health Organization estimated that people with diabetes (DM) are at 2–3 times higher risk for tuberculosis (TB). Studies have shown that DM not only increases the risk of active TB, but also puts co-affected persons at increased risk of poor outcomes. Objectives To determine the protective effect of metformin against TB in DM patients and also, to investigate the relationship between poor glycemic control and TB. Methods A case–control study was conducted over 8 months, where cases and controls were selected based on the inclusion and exclusion criteria of the study. The diabetics diagnosed with TB were selected as study group (SG = 152) and without TB were as control group (CG = 299). Exposure status of metformin in both groups were analyzed. Results The mean (SD) age of both CG and SG were 55.54 ± 11.82 and 52.80 ± 11.75, respectively. Majority of the subjects in the study were males. The mean hospital stay of SG and CG were 7 days and 6 days, respectively. Poor glycemic control (HbA1c > 8) observed in SG (51.7%) vs CG (31.4%). HbA1c value <7 is associated protective factor for TB occurrence [OR = 0.52 (95% CI 0.29–0.93)]. The protective effect of metformin against TB was 3.9-fold in diabetics (OR = 0.256, 0.16–0.40). Conclusion Poor glycemic control among diabetics is a risk factor for TB occurrence. The result shows metformin use is a protective agent against TB infection in diabetics. Hence, incorporation of metformin into standard clinical care would offer a therapeutic option for the prevention of TB.

UR - http://www.scopus.com/inward/record.url?scp=85016194243&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85016194243&partnerID=8YFLogxK

U2 - 10.1016/j.bjid.2017.01.001

DO - 10.1016/j.bjid.2017.01.001

M3 - Article

VL - 21

SP - 312

EP - 316

JO - Brazilian Journal of Infectious Diseases

JF - Brazilian Journal of Infectious Diseases

SN - 1413-8670

IS - 3

ER -