Protective effect of selenomethionine against cisplatin-induced nephrotoxicity in C57BL/6J mice bearing B16F1 melanoma without reducing antitumour activity

M. Rao, R. Kamath, M.N.A Rao

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Abstract

The effect of selenomethionine on cisplatin-induced nephrotoxicity and antitumour activity was studied in C57BL/6J mice bearing B16F1 melanoma. Intraperitoneal administration of 6 mg kg -1 cisplatin resulted in a significant reduction in body weight, elevation of blood urea nitrogen and serum creatinine levels on day 5. Selenomethionine, an antioxidant, protected tumour-bearing mice from cisplatin-induced nephrotoxicity, when given intraperitoneally 1 h before cisplatin. At a dose of 4 mg kg -1, selenomethionine gave 54%, 69% and 65% protection against reduction in body weight and elevation of blood urea nitrogen and serum creatinine levels, respectively. Significant protection was also observed at 1 mg kg -1. Administration of cisplatin alone to tumour-bearing mice resulted in significant antitumour activity as measured by tumour appearance, volume and weight. Pretreatment with selenomethionine (1 and 4 mg kg -1,) did not reduce the antitumour activity of cisplatin. These results suggest that selenomethionine protects against cisplatin-induced nephrotoxicity without interfering with antitumour activity.
Original languageUndefined/Unknown
Pages (from-to)549-552
Number of pages4
JournalPharmacy and Pharmacology Communications
Volume4
Issue number11
Publication statusPublished - 1998

Cite this

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title = "Protective effect of selenomethionine against cisplatin-induced nephrotoxicity in C57BL/6J mice bearing B16F1 melanoma without reducing antitumour activity",
abstract = "The effect of selenomethionine on cisplatin-induced nephrotoxicity and antitumour activity was studied in C57BL/6J mice bearing B16F1 melanoma. Intraperitoneal administration of 6 mg kg -1 cisplatin resulted in a significant reduction in body weight, elevation of blood urea nitrogen and serum creatinine levels on day 5. Selenomethionine, an antioxidant, protected tumour-bearing mice from cisplatin-induced nephrotoxicity, when given intraperitoneally 1 h before cisplatin. At a dose of 4 mg kg -1, selenomethionine gave 54{\%}, 69{\%} and 65{\%} protection against reduction in body weight and elevation of blood urea nitrogen and serum creatinine levels, respectively. Significant protection was also observed at 1 mg kg -1. Administration of cisplatin alone to tumour-bearing mice resulted in significant antitumour activity as measured by tumour appearance, volume and weight. Pretreatment with selenomethionine (1 and 4 mg kg -1,) did not reduce the antitumour activity of cisplatin. These results suggest that selenomethionine protects against cisplatin-induced nephrotoxicity without interfering with antitumour activity.",
author = "M. Rao and R. Kamath and M.N.A Rao",
note = "cited By 5",
year = "1998",
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volume = "4",
pages = "549--552",
journal = "Journal of Pharmacy and Pharmacology",
issn = "0022-3573",
publisher = "Pharmaceutical Press",
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TY - JOUR

T1 - Protective effect of selenomethionine against cisplatin-induced nephrotoxicity in C57BL/6J mice bearing B16F1 melanoma without reducing antitumour activity

AU - Rao, M.

AU - Kamath, R.

AU - Rao, M.N.A

N1 - cited By 5

PY - 1998

Y1 - 1998

N2 - The effect of selenomethionine on cisplatin-induced nephrotoxicity and antitumour activity was studied in C57BL/6J mice bearing B16F1 melanoma. Intraperitoneal administration of 6 mg kg -1 cisplatin resulted in a significant reduction in body weight, elevation of blood urea nitrogen and serum creatinine levels on day 5. Selenomethionine, an antioxidant, protected tumour-bearing mice from cisplatin-induced nephrotoxicity, when given intraperitoneally 1 h before cisplatin. At a dose of 4 mg kg -1, selenomethionine gave 54%, 69% and 65% protection against reduction in body weight and elevation of blood urea nitrogen and serum creatinine levels, respectively. Significant protection was also observed at 1 mg kg -1. Administration of cisplatin alone to tumour-bearing mice resulted in significant antitumour activity as measured by tumour appearance, volume and weight. Pretreatment with selenomethionine (1 and 4 mg kg -1,) did not reduce the antitumour activity of cisplatin. These results suggest that selenomethionine protects against cisplatin-induced nephrotoxicity without interfering with antitumour activity.

AB - The effect of selenomethionine on cisplatin-induced nephrotoxicity and antitumour activity was studied in C57BL/6J mice bearing B16F1 melanoma. Intraperitoneal administration of 6 mg kg -1 cisplatin resulted in a significant reduction in body weight, elevation of blood urea nitrogen and serum creatinine levels on day 5. Selenomethionine, an antioxidant, protected tumour-bearing mice from cisplatin-induced nephrotoxicity, when given intraperitoneally 1 h before cisplatin. At a dose of 4 mg kg -1, selenomethionine gave 54%, 69% and 65% protection against reduction in body weight and elevation of blood urea nitrogen and serum creatinine levels, respectively. Significant protection was also observed at 1 mg kg -1. Administration of cisplatin alone to tumour-bearing mice resulted in significant antitumour activity as measured by tumour appearance, volume and weight. Pretreatment with selenomethionine (1 and 4 mg kg -1,) did not reduce the antitumour activity of cisplatin. These results suggest that selenomethionine protects against cisplatin-induced nephrotoxicity without interfering with antitumour activity.

M3 - Article

VL - 4

SP - 549

EP - 552

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

SN - 0022-3573

IS - 11

ER -