Protective effect of Tinospora cordifolia on experimentally induced gastric ulcers in rats

K. L. Bairy, K. Roopa, S. Malini, C. M. Rao

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objectives: To study the possible antiulcer effects of alcoholic extract of Tinospora cordifolia in different animal models of ulcers. Methods and materials: The alcoholic extract of the whole plant was prepared and tested for antiulcer activity at the dose of 400 mg/Kg PO in pyloric ligation, ibuprofen and cold restraint induced gastric ulcer models. The effect of the extract was compared with famotidine (3.6mg Kg PO). Besides, the effect was also compared with misoprostal (7.2 μg/kg PO) in case of ibuprofen induced ulcer model. The antiulcer effects of the drugs were assessed on the parameters such as number, size and index of ulcers and the volume, acidity, and pH of gastric juice. Result: The extract of Tinospora cordifolia, famotidine and misoprostol significantly (p<0.05) reduced ulcer index in the models employed. While the antiulcer effect of the extract was comparable to that of the standard drugs in ibuprofen and stress induced ulcer models, its effect was significantly (p<0.05) lesser than that of famotidine in pyloric ligation method. Conclusion: Tinospora cordifolia possesses gastric ulcer protective principles.

Original languageEnglish
Pages (from-to)49-53
Number of pages5
JournalJournal of Natural Remedies
Volume2
Issue number1
Publication statusPublished - 2002

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Tinospora
Stomach Ulcer
Ulcer
Famotidine
Ibuprofen
Ligation
Misoprostol
Gastric Juice
Plant Extracts
Pharmaceutical Preparations
Animal Models

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

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abstract = "Objectives: To study the possible antiulcer effects of alcoholic extract of Tinospora cordifolia in different animal models of ulcers. Methods and materials: The alcoholic extract of the whole plant was prepared and tested for antiulcer activity at the dose of 400 mg/Kg PO in pyloric ligation, ibuprofen and cold restraint induced gastric ulcer models. The effect of the extract was compared with famotidine (3.6mg Kg PO). Besides, the effect was also compared with misoprostal (7.2 μg/kg PO) in case of ibuprofen induced ulcer model. The antiulcer effects of the drugs were assessed on the parameters such as number, size and index of ulcers and the volume, acidity, and pH of gastric juice. Result: The extract of Tinospora cordifolia, famotidine and misoprostol significantly (p<0.05) reduced ulcer index in the models employed. While the antiulcer effect of the extract was comparable to that of the standard drugs in ibuprofen and stress induced ulcer models, its effect was significantly (p<0.05) lesser than that of famotidine in pyloric ligation method. Conclusion: Tinospora cordifolia possesses gastric ulcer protective principles.",
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Protective effect of Tinospora cordifolia on experimentally induced gastric ulcers in rats. / Bairy, K. L.; Roopa, K.; Malini, S.; Rao, C. M.

In: Journal of Natural Remedies, Vol. 2, No. 1, 2002, p. 49-53.

Research output: Contribution to journalArticle

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T1 - Protective effect of Tinospora cordifolia on experimentally induced gastric ulcers in rats

AU - Bairy, K. L.

AU - Roopa, K.

AU - Malini, S.

AU - Rao, C. M.

PY - 2002

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N2 - Objectives: To study the possible antiulcer effects of alcoholic extract of Tinospora cordifolia in different animal models of ulcers. Methods and materials: The alcoholic extract of the whole plant was prepared and tested for antiulcer activity at the dose of 400 mg/Kg PO in pyloric ligation, ibuprofen and cold restraint induced gastric ulcer models. The effect of the extract was compared with famotidine (3.6mg Kg PO). Besides, the effect was also compared with misoprostal (7.2 μg/kg PO) in case of ibuprofen induced ulcer model. The antiulcer effects of the drugs were assessed on the parameters such as number, size and index of ulcers and the volume, acidity, and pH of gastric juice. Result: The extract of Tinospora cordifolia, famotidine and misoprostol significantly (p<0.05) reduced ulcer index in the models employed. While the antiulcer effect of the extract was comparable to that of the standard drugs in ibuprofen and stress induced ulcer models, its effect was significantly (p<0.05) lesser than that of famotidine in pyloric ligation method. Conclusion: Tinospora cordifolia possesses gastric ulcer protective principles.

AB - Objectives: To study the possible antiulcer effects of alcoholic extract of Tinospora cordifolia in different animal models of ulcers. Methods and materials: The alcoholic extract of the whole plant was prepared and tested for antiulcer activity at the dose of 400 mg/Kg PO in pyloric ligation, ibuprofen and cold restraint induced gastric ulcer models. The effect of the extract was compared with famotidine (3.6mg Kg PO). Besides, the effect was also compared with misoprostal (7.2 μg/kg PO) in case of ibuprofen induced ulcer model. The antiulcer effects of the drugs were assessed on the parameters such as number, size and index of ulcers and the volume, acidity, and pH of gastric juice. Result: The extract of Tinospora cordifolia, famotidine and misoprostol significantly (p<0.05) reduced ulcer index in the models employed. While the antiulcer effect of the extract was comparable to that of the standard drugs in ibuprofen and stress induced ulcer models, its effect was significantly (p<0.05) lesser than that of famotidine in pyloric ligation method. Conclusion: Tinospora cordifolia possesses gastric ulcer protective principles.

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