To study the possible antiulcer effects of water extracts of Moringa oleifera in two animal models of ulcers. The water extract of leaves was prepared and tested for antiulcer activity at the dose level of 200mg and 400 mg/kg PO in pyloric ligation and ibuprofen induced gastric ulcer models. The effect of the extract was compared famotidine(3.6 mg/kg PO). The antiulcer effects of the drugs were assessed on the parameters such as number, size and index of ulcers and the volume, acidity and pH of gastric juice. The extract of Moringa oleifera and famotidine significantly (p<0.001) reduced ulcer index in the model employed. Both Moringa oleifera extract and famotidine reduced significantly (p<0.001) the free and total acidity of gastric juice. Moringa oleifera possesses gastric ulcer protective principles.
|Number of pages||6|
|Journal||Research Journal of Pharmaceutical, Biological and Chemical Sciences|
|Publication status||Published - 04-2011|
All Science Journal Classification (ASJC) codes
- Pharmacology, Toxicology and Pharmaceutics(all)
- Biochemistry, Genetics and Molecular Biology(all)