Protective effects of selenomethionine against cisplatin-induced renal toxicity in mice and rats

M Rao, M.N.A. Rao

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The effect of selenomethionine on the toxicity of cisplatin has been studied in mice and rats. When selenomethionine (0.5-4 mg kg-1) was administered intraperitoneally to mice 1 h before intraperitoneal cisplatin (6 mg kg-1), the toxicity of cisplatin, as measured by loss of body weight and blood urea nitrogen and serum creatinine levels, was reduced significantly. The protection was dose-dependent but less when given orally. Similar results were obtained with rats. Deterioration of renal function was characterized by reduced creatinine clearance, and increased excretion of urinary protein was significantly reversed. Partial but significant protection was also observed against capsulation-induced reduction of white blood-cell count. Protective properties were further demonstrated by increased survival of mice pretreated with selenomethionine compared with the lethality observed for animals given cisplatin only. These results suggested that selenomethionine protects against cisplatin-induced renal and other toxicity. The study has many clinical implications in cancer chemotherapy and needs further investigation.
Original languageUndefined/Unknown
Pages (from-to)687-691
Number of pages5
JournalJournal of Pharmacy and Pharmacology
Volume50
Issue number6
Publication statusPublished - 1998

Cite this

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title = "Protective effects of selenomethionine against cisplatin-induced renal toxicity in mice and rats",
abstract = "The effect of selenomethionine on the toxicity of cisplatin has been studied in mice and rats. When selenomethionine (0.5-4 mg kg-1) was administered intraperitoneally to mice 1 h before intraperitoneal cisplatin (6 mg kg-1), the toxicity of cisplatin, as measured by loss of body weight and blood urea nitrogen and serum creatinine levels, was reduced significantly. The protection was dose-dependent but less when given orally. Similar results were obtained with rats. Deterioration of renal function was characterized by reduced creatinine clearance, and increased excretion of urinary protein was significantly reversed. Partial but significant protection was also observed against capsulation-induced reduction of white blood-cell count. Protective properties were further demonstrated by increased survival of mice pretreated with selenomethionine compared with the lethality observed for animals given cisplatin only. These results suggested that selenomethionine protects against cisplatin-induced renal and other toxicity. The study has many clinical implications in cancer chemotherapy and needs further investigation.",
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Protective effects of selenomethionine against cisplatin-induced renal toxicity in mice and rats. / Rao, M; Rao, M.N.A.

In: Journal of Pharmacy and Pharmacology, Vol. 50, No. 6, 1998, p. 687-691.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Protective effects of selenomethionine against cisplatin-induced renal toxicity in mice and rats

AU - Rao, M

AU - Rao, M.N.A.

N1 - cited By 30

PY - 1998

Y1 - 1998

N2 - The effect of selenomethionine on the toxicity of cisplatin has been studied in mice and rats. When selenomethionine (0.5-4 mg kg-1) was administered intraperitoneally to mice 1 h before intraperitoneal cisplatin (6 mg kg-1), the toxicity of cisplatin, as measured by loss of body weight and blood urea nitrogen and serum creatinine levels, was reduced significantly. The protection was dose-dependent but less when given orally. Similar results were obtained with rats. Deterioration of renal function was characterized by reduced creatinine clearance, and increased excretion of urinary protein was significantly reversed. Partial but significant protection was also observed against capsulation-induced reduction of white blood-cell count. Protective properties were further demonstrated by increased survival of mice pretreated with selenomethionine compared with the lethality observed for animals given cisplatin only. These results suggested that selenomethionine protects against cisplatin-induced renal and other toxicity. The study has many clinical implications in cancer chemotherapy and needs further investigation.

AB - The effect of selenomethionine on the toxicity of cisplatin has been studied in mice and rats. When selenomethionine (0.5-4 mg kg-1) was administered intraperitoneally to mice 1 h before intraperitoneal cisplatin (6 mg kg-1), the toxicity of cisplatin, as measured by loss of body weight and blood urea nitrogen and serum creatinine levels, was reduced significantly. The protection was dose-dependent but less when given orally. Similar results were obtained with rats. Deterioration of renal function was characterized by reduced creatinine clearance, and increased excretion of urinary protein was significantly reversed. Partial but significant protection was also observed against capsulation-induced reduction of white blood-cell count. Protective properties were further demonstrated by increased survival of mice pretreated with selenomethionine compared with the lethality observed for animals given cisplatin only. These results suggested that selenomethionine protects against cisplatin-induced renal and other toxicity. The study has many clinical implications in cancer chemotherapy and needs further investigation.

M3 - Article

VL - 50

SP - 687

EP - 691

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

SN - 0022-3573

IS - 6

ER -