Protective Role of Co-administration of Vitamin D in Monosodium Glutamate Induced Obesity in Female Rats

Padmanabha Nandan, Arun Kumar Nayanatara, Roopesh Poojary, K. Bhagyalakshmi, M. Nirupama, Rekha D. Kini

Research output: Contribution to journalArticle

Abstract

Purpose: Obesity in females is an emerging health problem. The consumption of MSG has been considered as a risk factor for obesity. The tastemakers in Chinese and fast foods, such as fish sauce and soy sauce, contain very high levels of glutamate. The deficiency of Vitamin D is associated with obesity and metabolic syndrome. Therefore, the present study aimed to determine the effect of co-administration of Vitamin D on body weight control in MSG-induced obese rats. Methods: Eighteen adult female Wistar rats were randomly divided into three groups equally. The first group (Group I) was treated with saline served as the control; the second group (Group II) received a daily oral dose of 5 g/kg Body weight of MSG; the third group (Group III) received the same dose of MSG along with calcitriol (0.2 mcg/kg BW) for 15 days. Results: The body weight, food, and water intake were measured. MSG treated rats showed a significant increase (P < 0.001) in the body weight, food, and water intake but significant decrease (P < 0.001) was observed in the rats treated with MSG along with Vitamin D. Conclusion: Ingestion of Vitamin D suppresses body weight gain in MSG-induced obese rats. Active agents in Vitamin D are useful for the prevention and treatment of obesity. Foods tested with high glutamate levels can be fortified with minute quantities of calcitriol to combat the adverse effects without compromising on the taste of the food processed. The fortification of junk foods might also combat largely prevalent Vitamin D deficiency in India.

Original languageEnglish
JournalJournal of the National Medical Association
DOIs
Publication statusPublished - 11-01-2018

Fingerprint

Sodium Glutamate
Vitamin D
Obesity
Body Weight
Vitamin D Deficiency
Body Water
Eating
Calcitriol
Food
Drinking
Glutamic Acid
Fast Foods
Soy Foods
Weight Gain
Wistar Rats
India
Fishes
Health

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{cc9a5e272702452798ab639050e66663,
title = "Protective Role of Co-administration of Vitamin D in Monosodium Glutamate Induced Obesity in Female Rats",
abstract = "Purpose: Obesity in females is an emerging health problem. The consumption of MSG has been considered as a risk factor for obesity. The tastemakers in Chinese and fast foods, such as fish sauce and soy sauce, contain very high levels of glutamate. The deficiency of Vitamin D is associated with obesity and metabolic syndrome. Therefore, the present study aimed to determine the effect of co-administration of Vitamin D on body weight control in MSG-induced obese rats. Methods: Eighteen adult female Wistar rats were randomly divided into three groups equally. The first group (Group I) was treated with saline served as the control; the second group (Group II) received a daily oral dose of 5 g/kg Body weight of MSG; the third group (Group III) received the same dose of MSG along with calcitriol (0.2 mcg/kg BW) for 15 days. Results: The body weight, food, and water intake were measured. MSG treated rats showed a significant increase (P < 0.001) in the body weight, food, and water intake but significant decrease (P < 0.001) was observed in the rats treated with MSG along with Vitamin D. Conclusion: Ingestion of Vitamin D suppresses body weight gain in MSG-induced obese rats. Active agents in Vitamin D are useful for the prevention and treatment of obesity. Foods tested with high glutamate levels can be fortified with minute quantities of calcitriol to combat the adverse effects without compromising on the taste of the food processed. The fortification of junk foods might also combat largely prevalent Vitamin D deficiency in India.",
author = "Padmanabha Nandan and Nayanatara, {Arun Kumar} and Roopesh Poojary and K. Bhagyalakshmi and M. Nirupama and Kini, {Rekha D.}",
year = "2018",
month = "1",
day = "11",
doi = "10.1016/j.jnma.2017.03.006",
language = "English",
journal = "Journal of the National Medical Association",
issn = "1943-4693",
publisher = "National Medical Association",

}

TY - JOUR

T1 - Protective Role of Co-administration of Vitamin D in Monosodium Glutamate Induced Obesity in Female Rats

AU - Nandan, Padmanabha

AU - Nayanatara, Arun Kumar

AU - Poojary, Roopesh

AU - Bhagyalakshmi, K.

AU - Nirupama, M.

AU - Kini, Rekha D.

PY - 2018/1/11

Y1 - 2018/1/11

N2 - Purpose: Obesity in females is an emerging health problem. The consumption of MSG has been considered as a risk factor for obesity. The tastemakers in Chinese and fast foods, such as fish sauce and soy sauce, contain very high levels of glutamate. The deficiency of Vitamin D is associated with obesity and metabolic syndrome. Therefore, the present study aimed to determine the effect of co-administration of Vitamin D on body weight control in MSG-induced obese rats. Methods: Eighteen adult female Wistar rats were randomly divided into three groups equally. The first group (Group I) was treated with saline served as the control; the second group (Group II) received a daily oral dose of 5 g/kg Body weight of MSG; the third group (Group III) received the same dose of MSG along with calcitriol (0.2 mcg/kg BW) for 15 days. Results: The body weight, food, and water intake were measured. MSG treated rats showed a significant increase (P < 0.001) in the body weight, food, and water intake but significant decrease (P < 0.001) was observed in the rats treated with MSG along with Vitamin D. Conclusion: Ingestion of Vitamin D suppresses body weight gain in MSG-induced obese rats. Active agents in Vitamin D are useful for the prevention and treatment of obesity. Foods tested with high glutamate levels can be fortified with minute quantities of calcitriol to combat the adverse effects without compromising on the taste of the food processed. The fortification of junk foods might also combat largely prevalent Vitamin D deficiency in India.

AB - Purpose: Obesity in females is an emerging health problem. The consumption of MSG has been considered as a risk factor for obesity. The tastemakers in Chinese and fast foods, such as fish sauce and soy sauce, contain very high levels of glutamate. The deficiency of Vitamin D is associated with obesity and metabolic syndrome. Therefore, the present study aimed to determine the effect of co-administration of Vitamin D on body weight control in MSG-induced obese rats. Methods: Eighteen adult female Wistar rats were randomly divided into three groups equally. The first group (Group I) was treated with saline served as the control; the second group (Group II) received a daily oral dose of 5 g/kg Body weight of MSG; the third group (Group III) received the same dose of MSG along with calcitriol (0.2 mcg/kg BW) for 15 days. Results: The body weight, food, and water intake were measured. MSG treated rats showed a significant increase (P < 0.001) in the body weight, food, and water intake but significant decrease (P < 0.001) was observed in the rats treated with MSG along with Vitamin D. Conclusion: Ingestion of Vitamin D suppresses body weight gain in MSG-induced obese rats. Active agents in Vitamin D are useful for the prevention and treatment of obesity. Foods tested with high glutamate levels can be fortified with minute quantities of calcitriol to combat the adverse effects without compromising on the taste of the food processed. The fortification of junk foods might also combat largely prevalent Vitamin D deficiency in India.

UR - http://www.scopus.com/inward/record.url?scp=85017456186&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017456186&partnerID=8YFLogxK

U2 - 10.1016/j.jnma.2017.03.006

DO - 10.1016/j.jnma.2017.03.006

M3 - Article

JO - Journal of the National Medical Association

JF - Journal of the National Medical Association

SN - 1943-4693

ER -