Protein carbonyl content and thiols in patients with Rheumatoid arthritis

Sreekantha, R. Kowsalya, S. S. Avinash, Vinod Chandran, Remya, M. Amareshwara

Research output: Contribution to journalArticle

Abstract

Objectives: Proteins modified under oxidative stress seem to play a pivotal role in pathogenesis of several diseases. The present study was undertaken to know the relation between protein carbonylation and antioxidants in the form of glutathione and albumin in rheumatoid arthritis patients. Methods: Protein carbonylation & glutathione levels were measured in plasma in all the 30 patients and 25 controls using spectrophotometric methods along with total protein and albumin. Results: There was significant increase in protein carbonylation content (P<0.001) associated with a significant decrease in glutathione and albumin levels (P<0.001) in patients compared to healthy controls. A significant negative correlation of protein carbonylation with glutathione and albumin was also noted. Conclusion: Thus our study suggests a possible role for oxidatively modified proteins in form of protein carbonyls in mediation of inflammation in rheumatoid arthritis leading to increased consumption of available antioxidants in the body.

Original languageEnglish
Pages (from-to)555-557
Number of pages3
JournalBiomedicine
Volume31
Issue number4
Publication statusPublished - 01-10-2011
Externally publishedYes

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Protein Carbonylation
Sulfhydryl Compounds
Glutathione
Albumins
Rheumatoid Arthritis
Carbonylation
Proteins
Antioxidants
Oxidative Stress
Inflammation
Oxidative stress
Plasmas

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Sreekantha, Kowsalya, R., Avinash, S. S., Chandran, V., Remya, & Amareshwara, M. (2011). Protein carbonyl content and thiols in patients with Rheumatoid arthritis. Biomedicine, 31(4), 555-557.
Sreekantha ; Kowsalya, R. ; Avinash, S. S. ; Chandran, Vinod ; Remya ; Amareshwara, M. / Protein carbonyl content and thiols in patients with Rheumatoid arthritis. In: Biomedicine. 2011 ; Vol. 31, No. 4. pp. 555-557.
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Sreekantha, Kowsalya, R, Avinash, SS, Chandran, V, Remya & Amareshwara, M 2011, 'Protein carbonyl content and thiols in patients with Rheumatoid arthritis', Biomedicine, vol. 31, no. 4, pp. 555-557.

Protein carbonyl content and thiols in patients with Rheumatoid arthritis. / Sreekantha; Kowsalya, R.; Avinash, S. S.; Chandran, Vinod; Remya; Amareshwara, M.

In: Biomedicine, Vol. 31, No. 4, 01.10.2011, p. 555-557.

Research output: Contribution to journalArticle

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AU - Avinash, S. S.

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AB - Objectives: Proteins modified under oxidative stress seem to play a pivotal role in pathogenesis of several diseases. The present study was undertaken to know the relation between protein carbonylation and antioxidants in the form of glutathione and albumin in rheumatoid arthritis patients. Methods: Protein carbonylation & glutathione levels were measured in plasma in all the 30 patients and 25 controls using spectrophotometric methods along with total protein and albumin. Results: There was significant increase in protein carbonylation content (P<0.001) associated with a significant decrease in glutathione and albumin levels (P<0.001) in patients compared to healthy controls. A significant negative correlation of protein carbonylation with glutathione and albumin was also noted. Conclusion: Thus our study suggests a possible role for oxidatively modified proteins in form of protein carbonyls in mediation of inflammation in rheumatoid arthritis leading to increased consumption of available antioxidants in the body.

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Sreekantha, Kowsalya R, Avinash SS, Chandran V, Remya, Amareshwara M. Protein carbonyl content and thiols in patients with Rheumatoid arthritis. Biomedicine. 2011 Oct 1;31(4):555-557.