Protein kinase C-mediated sodium glucose transporter 1 activation in precondition-induced cardioprotection

Abhinav Kanwal, Sujatha Kasetti, Uday Kumar Putcha, Shailendra Asthana, Sanjay K. Banerjee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The concept of cardioprotection through preconditioning against ischemia-reperfusion (I/R) injury is well known and established. However, among different proposed mechanisms regarding the concept of ischemic preconditioning, protein kinase C (PKC)-mediated cardioprotection through ischemic preconditioning plays a key role in myocardial I/R injury. Thus, this study was designed to find the relationship between PKC and sodium glucose transporter 1 (SGLT1) in preconditioning-induced cardioprotection, which is ill reported till now. By applying a multifaceted approach, we demonstrated that PKC activates SGLT1, which curbed oxidative stress and apoptosis against I/R injury. PKC activation enhances cardiac glucose uptake through SGLT1 and seems essential in preventing I/R-induced cardiac injury, indicating a possible cross-talk between PKC and SGLT1.

Original languageEnglish
Pages (from-to)2929-2938
Number of pages10
JournalDrug Design, Development and Therapy
Volume10
DOIs
Publication statusPublished - 14-09-2016

Fingerprint

Sodium-Glucose Transporter 1
Protein Kinase C
Reperfusion Injury
Ischemic Preconditioning
Myocardial Reperfusion Injury
Reperfusion
Myocardial Ischemia
Oxidative Stress
Ischemia
Apoptosis
Glucose
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

Cite this

Kanwal, Abhinav ; Kasetti, Sujatha ; Putcha, Uday Kumar ; Asthana, Shailendra ; Banerjee, Sanjay K. / Protein kinase C-mediated sodium glucose transporter 1 activation in precondition-induced cardioprotection. In: Drug Design, Development and Therapy. 2016 ; Vol. 10. pp. 2929-2938.
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Protein kinase C-mediated sodium glucose transporter 1 activation in precondition-induced cardioprotection. / Kanwal, Abhinav; Kasetti, Sujatha; Putcha, Uday Kumar; Asthana, Shailendra; Banerjee, Sanjay K.

In: Drug Design, Development and Therapy, Vol. 10, 14.09.2016, p. 2929-2938.

Research output: Contribution to journalArticle

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