Protein kinase C-mediated sodium glucose transporter 1 activation in precondition-induced cardioprotection

Abhinav Kanwal, Sujatha Kasetti, Uday Kumar Putcha, Shailendra Asthana, Sanjay K. Banerjee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The concept of cardioprotection through preconditioning against ischemia-reperfusion (I/R) injury is well known and established. However, among different proposed mechanisms regarding the concept of ischemic preconditioning, protein kinase C (PKC)-mediated cardioprotection through ischemic preconditioning plays a key role in myocardial I/R injury. Thus, this study was designed to find the relationship between PKC and sodium glucose transporter 1 (SGLT1) in preconditioning-induced cardioprotection, which is ill reported till now. By applying a multifaceted approach, we demonstrated that PKC activates SGLT1, which curbed oxidative stress and apoptosis against I/R injury. PKC activation enhances cardiac glucose uptake through SGLT1 and seems essential in preventing I/R-induced cardiac injury, indicating a possible cross-talk between PKC and SGLT1.

Original languageEnglish
Pages (from-to)2929-2938
Number of pages10
JournalDrug Design, Development and Therapy
Volume10
DOIs
Publication statusPublished - 14-09-2016

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

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