Protein kinases as drug targets in human and animal diseases

Suvarna G. Kini, Vikas Garg, Sarada Prasanna, Revathi Rajappan, Muhammad Mubeen

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Almost thirty percent of the protein targets currently under exploration and study constitute the protein kinases which have always attracted the pharmaceutical companies as they are easy targets for drug development. Although the kinases will remain major focus of oncology for many years to come in the development of anticancer drugs, the number of kinase inhibitors as therapeutic targets for the treatment of several other diseases which are undergoing clinical trials are exponentially increasin. In this review, we discuss very briefly the different types of protein kinases that have been used as targets for developing drugs for cancer, inflammation, autoimmune disease, heart disease andanimal diseases.

Original languageEnglish
Pages (from-to)99-106
Number of pages8
JournalCurrent Enzyme Inhibition
Volume13
Issue number2
DOIs
Publication statusPublished - 01-08-2017

Fingerprint

Animal Diseases
Protein Kinases
Animals
Pharmaceutical Preparations
Phosphotransferases
Oncology
Autoimmune Diseases
Heart Diseases
Clinical Trials
Inflammation
Industry
Neoplasms
Proteins
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Drug Discovery

Cite this

Kini, Suvarna G. ; Garg, Vikas ; Prasanna, Sarada ; Rajappan, Revathi ; Mubeen, Muhammad. / Protein kinases as drug targets in human and animal diseases. In: Current Enzyme Inhibition. 2017 ; Vol. 13, No. 2. pp. 99-106.
@article{08330c1946f148e2b6a834487ebab03b,
title = "Protein kinases as drug targets in human and animal diseases",
abstract = "Almost thirty percent of the protein targets currently under exploration and study constitute the protein kinases which have always attracted the pharmaceutical companies as they are easy targets for drug development. Although the kinases will remain major focus of oncology for many years to come in the development of anticancer drugs, the number of kinase inhibitors as therapeutic targets for the treatment of several other diseases which are undergoing clinical trials are exponentially increasin. In this review, we discuss very briefly the different types of protein kinases that have been used as targets for developing drugs for cancer, inflammation, autoimmune disease, heart disease andanimal diseases.",
author = "Kini, {Suvarna G.} and Vikas Garg and Sarada Prasanna and Revathi Rajappan and Muhammad Mubeen",
year = "2017",
month = "8",
day = "1",
doi = "10.2174/1573408013666161128144216",
language = "English",
volume = "13",
pages = "99--106",
journal = "Current Enzyme Inhibition",
issn = "1573-4080",
publisher = "Bentham Science Publishers B.V.",
number = "2",

}

Protein kinases as drug targets in human and animal diseases. / Kini, Suvarna G.; Garg, Vikas; Prasanna, Sarada; Rajappan, Revathi; Mubeen, Muhammad.

In: Current Enzyme Inhibition, Vol. 13, No. 2, 01.08.2017, p. 99-106.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Protein kinases as drug targets in human and animal diseases

AU - Kini, Suvarna G.

AU - Garg, Vikas

AU - Prasanna, Sarada

AU - Rajappan, Revathi

AU - Mubeen, Muhammad

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Almost thirty percent of the protein targets currently under exploration and study constitute the protein kinases which have always attracted the pharmaceutical companies as they are easy targets for drug development. Although the kinases will remain major focus of oncology for many years to come in the development of anticancer drugs, the number of kinase inhibitors as therapeutic targets for the treatment of several other diseases which are undergoing clinical trials are exponentially increasin. In this review, we discuss very briefly the different types of protein kinases that have been used as targets for developing drugs for cancer, inflammation, autoimmune disease, heart disease andanimal diseases.

AB - Almost thirty percent of the protein targets currently under exploration and study constitute the protein kinases which have always attracted the pharmaceutical companies as they are easy targets for drug development. Although the kinases will remain major focus of oncology for many years to come in the development of anticancer drugs, the number of kinase inhibitors as therapeutic targets for the treatment of several other diseases which are undergoing clinical trials are exponentially increasin. In this review, we discuss very briefly the different types of protein kinases that have been used as targets for developing drugs for cancer, inflammation, autoimmune disease, heart disease andanimal diseases.

UR - http://www.scopus.com/inward/record.url?scp=85025138279&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85025138279&partnerID=8YFLogxK

U2 - 10.2174/1573408013666161128144216

DO - 10.2174/1573408013666161128144216

M3 - Review article

VL - 13

SP - 99

EP - 106

JO - Current Enzyme Inhibition

JF - Current Enzyme Inhibition

SN - 1573-4080

IS - 2

ER -