Protein oxidation

A potential cause of hypoalbuminemia in oral cancer

Vinod Chandran, M. Anitha, S. S. Avinash, Gayathri M. Rao, Beena V. Shetty, K. Sudha

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This study examined the role of the free radical induced protein oxidation and decreased antioxidant defense mechanism as a causative agent of hypoalbuminemia in patients with oral cancer. Plasma advanced oxidation protein products (AOPP) and % hemolysis were estimated as protein oxidation indicators. Antioxidant status was evaluated by determining GSH, total thiols, albumin and total antioxidant activity in plasma. The parameters were estimated by spectrophotometric methods. Data was compared with the samples collected from age and sex matched controls. It was observed that there was a significant increase in protein oxidation products and a non significant decrease in plasma protein thiols in oral cancer patients. However, the decrease in plasma total thiols was significant compared to normal subjects. The decrease in blood GSH, plasma GSH, plasma total protein and albumin were significant in these patients compared to controls. Total antioxidant activity of oral cancer patients decreased significantly compared to controls. Oxidative stress, weak antioxidant defense or both can be considered to be important players in causing hypoalbuminemia in multimechanistic pathogenesis of oral cancer.

Original languageEnglish
Pages (from-to)227-230
Number of pages4
JournalBiomedical Research
Volume23
Issue number2
Publication statusPublished - 01-04-2012

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Hypoalbuminemia
Mouth Neoplasms
Antioxidants
Plasmas
Oxidation
Sulfhydryl Compounds
Proteins
Blood Proteins
Albumins
Advanced Oxidation Protein Products
Oxidative stress
Hemolysis
Serum Albumin
Free Radicals
Oxidative Stress
Blood

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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Protein oxidation : A potential cause of hypoalbuminemia in oral cancer. / Chandran, Vinod; Anitha, M.; Avinash, S. S.; Rao, Gayathri M.; Shetty, Beena V.; Sudha, K.

In: Biomedical Research, Vol. 23, No. 2, 01.04.2012, p. 227-230.

Research output: Contribution to journalArticle

TY - JOUR

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T2 - A potential cause of hypoalbuminemia in oral cancer

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AU - Sudha, K.

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AB - This study examined the role of the free radical induced protein oxidation and decreased antioxidant defense mechanism as a causative agent of hypoalbuminemia in patients with oral cancer. Plasma advanced oxidation protein products (AOPP) and % hemolysis were estimated as protein oxidation indicators. Antioxidant status was evaluated by determining GSH, total thiols, albumin and total antioxidant activity in plasma. The parameters were estimated by spectrophotometric methods. Data was compared with the samples collected from age and sex matched controls. It was observed that there was a significant increase in protein oxidation products and a non significant decrease in plasma protein thiols in oral cancer patients. However, the decrease in plasma total thiols was significant compared to normal subjects. The decrease in blood GSH, plasma GSH, plasma total protein and albumin were significant in these patients compared to controls. Total antioxidant activity of oral cancer patients decreased significantly compared to controls. Oxidative stress, weak antioxidant defense or both can be considered to be important players in causing hypoalbuminemia in multimechanistic pathogenesis of oral cancer.

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