Protein profile study of clinical samples of ovarian cancer using High Performance Liquid Chromatography-Laser Induced Fluorescence (HPLC-LIF)

Sameer Kumar Singh; Remila L. Martis; Sujatha; Rani A. Bhat; Pralhad Kushtagi; Lavanya Rai; V. B. Kartha; C. Santhosh

doi:10.1117/12.647321

Protein profile study of clinical samples of ovarian cancer using High Performance Liquid Chromatography-Laser Induced Fluorescence (HPLC-LIF)

Sameer Kumar Singh, Remila L. Martis, Sujatha, Rani A. Bhat, Pralhad Kushtagi, Lavanya Rai, V. B. Kartha, C. Santhosh

Research output: Contribution to journal › Article › peer-review

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Abstract

New techniques for the early detection of cancer are fast emerging. This is essential for more effective diagnosis and control of the disease. We have used a High Performance Liquid Chromatography-Laser Induced Fluorescence (HPLC-LIF) technique to record chromatograms of proteins in serum and ovarian tissue samples. The recorded chromatograms of normal, benign and malignant samples were analyzed using statistical (Principal Component Analysis) methods. It is shown that chromatograms of the samples can be classified into sets, and a model based on such a classification can be used to analyze protein profiles of test samples of serum and ovarian tissue for the detection of malignancies.

Original language	English
Article number	60920N
Journal	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	6092
DOIs	https://doi.org/10.1117/12.647321
Publication status	Published - 29-06-2006

All Science Journal Classification (ASJC) codes

Engineering(all)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Singh, S. K., Martis, R. L., Sujatha, Bhat, R. A., Kushtagi, P., Rai, L., Kartha, V. B., & Santhosh, C. (2006). Protein profile study of clinical samples of ovarian cancer using High Performance Liquid Chromatography-Laser Induced Fluorescence (HPLC-LIF). Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 6092, [60920N]. https://doi.org/10.1117/12.647321

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AU - Bhat, Rani A.

AU - Kushtagi, Pralhad

AU - Rai, Lavanya

AU - Kartha, V. B.

AU - Santhosh, C.

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Protein profile study of clinical samples of ovarian cancer using High Performance Liquid Chromatography-Laser Induced Fluorescence (HPLC-LIF)

Abstract

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