Protein thiols and butryrylcholinestrase in saliva of oral cancer patients

Yousef Rezaei Chianeh, Rashmi Manjunath, Krishnananda Prabhu, Donald Fernandes, M. Vidyasagar, Asha Kamath

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Oral squamous cell carcinoma is one of the most common malignancies recognized. Biomarkers which can predict presence of cancer and its progression can help in better management of these disorders. Over production of lipid peroxidation byproducts and disturbances in antioxidant defense system have been implicated in the pathogenesis of several diseases including oral cancer. Studies have shown a correlation of butyrylcholinesterase (BChE), with tumourigenesis, cell proliferation and cell differentiation. Earlier we have observed a significant elevation in plasma BChE and protein thiols in oral cancer patients which correlated well with stages of cancer. As it was not clear whether the above markers will be altered in saliva of oral cancer patients this study was undertaken. Institutional Ethics Committee gave permission to carry out this study. Total of 55 subjects comprising healthy controls (n = 30) and biopsy proven oral cancer patients (n = 25) consented to participate in this study. Salivary samples from cases were taken before any definitive treatment. Protein thiols and BChE were estimated in salivary samples using validated assay methods. Oral cancer patients had a significant increase in pre-treatment salivary BChE levels (p ≤ 0.001) and a significant decrease (p ≤ 0.001) in salivary thiols as compared to respective values in controls. Salivary protein thiols and BChE may have a role in pathophysiology of oral cancer. Saliva can be used as a potential non-invasive screening tool in oral cancer patients.

Original languageEnglish
Pages (from-to)238-241
Number of pages4
JournalIndian Journal of Clinical Biochemistry
Volume29
Issue number2
DOIs
Publication statusPublished - 2014

Fingerprint

Butyrylcholinesterase
Mouth Neoplasms
Saliva
Sulfhydryl Compounds
Proteins
Salivary Proteins and Peptides
Biopsy
Cell proliferation
Biomarkers
Neoplasms
Ethics Committees
Byproducts
Assays
Screening
Antioxidants
Lipids
Plasmas
Lipid Peroxidation
Blood Proteins
Cell Differentiation

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

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abstract = "Oral squamous cell carcinoma is one of the most common malignancies recognized. Biomarkers which can predict presence of cancer and its progression can help in better management of these disorders. Over production of lipid peroxidation byproducts and disturbances in antioxidant defense system have been implicated in the pathogenesis of several diseases including oral cancer. Studies have shown a correlation of butyrylcholinesterase (BChE), with tumourigenesis, cell proliferation and cell differentiation. Earlier we have observed a significant elevation in plasma BChE and protein thiols in oral cancer patients which correlated well with stages of cancer. As it was not clear whether the above markers will be altered in saliva of oral cancer patients this study was undertaken. Institutional Ethics Committee gave permission to carry out this study. Total of 55 subjects comprising healthy controls (n = 30) and biopsy proven oral cancer patients (n = 25) consented to participate in this study. Salivary samples from cases were taken before any definitive treatment. Protein thiols and BChE were estimated in salivary samples using validated assay methods. Oral cancer patients had a significant increase in pre-treatment salivary BChE levels (p ≤ 0.001) and a significant decrease (p ≤ 0.001) in salivary thiols as compared to respective values in controls. Salivary protein thiols and BChE may have a role in pathophysiology of oral cancer. Saliva can be used as a potential non-invasive screening tool in oral cancer patients.",
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Protein thiols and butryrylcholinestrase in saliva of oral cancer patients. / Chianeh, Yousef Rezaei; Manjunath, Rashmi; Prabhu, Krishnananda; Fernandes, Donald; Vidyasagar, M.; Kamath, Asha.

In: Indian Journal of Clinical Biochemistry, Vol. 29, No. 2, 2014, p. 238-241.

Research output: Contribution to journalArticle

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AU - Manjunath, Rashmi

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AU - Kamath, Asha

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