Protein thiols and thiobarbituric acid reactive substance status in colon cancer patients

B. Shivananda Nayak, Sneha Pinto

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective. Colon cancer is the most common malignancy found in the developed countries. Cancer initiation and progression is known to be associated with the formation of reactive oxygen species, formed in excess in the gastrointestinal tract. The aim of the study was to assess the levels of protein thiols and thiobarbituric acid reactive substances (TBARS) in patients with colon cancer. Material and methods. Serum samples were obtained from 60 subjects (M and F, mean age 50±15 years), 30 of which were from colon cancer patients and 30 from healthy individuals. All the serum samples were analyzed for carcinoembryonic antigen (CEA), protein thiols and TBARS. Results. The levels of protein thiols were significantly lower in colon cancer patients (p<0.001) than in the healthy controls. The TBARS levels in colon cancer patients were moderately high (p<0.05) in comparison with those of the controls. Conclusions. Low levels of protein thiols and elevated TBARS of colon cancer patients support the hypothesis that colon cancer is associated with reactive oxygen species. Therefore protein thiols and TBARS may serve as additive non-invasive biochemical markers of oxidative stress in colon cancer and this hypothesis needs to be further investigated.

Original languageEnglish
Pages (from-to)848-851
Number of pages4
JournalScandinavian Journal of Gastroenterology
Volume42
Issue number7
DOIs
Publication statusPublished - 15-06-2007
Externally publishedYes

Fingerprint

Thiobarbituric Acid Reactive Substances
Sulfhydryl Compounds
Colonic Neoplasms
Proteins
Reactive Oxygen Species
Carcinoembryonic Antigen
Serum
Developed Countries
Gastrointestinal Tract
Neoplasms
Oxidative Stress
Biomarkers

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

@article{b9ce607a32e24d409113f6095b1a0d27,
title = "Protein thiols and thiobarbituric acid reactive substance status in colon cancer patients",
abstract = "Objective. Colon cancer is the most common malignancy found in the developed countries. Cancer initiation and progression is known to be associated with the formation of reactive oxygen species, formed in excess in the gastrointestinal tract. The aim of the study was to assess the levels of protein thiols and thiobarbituric acid reactive substances (TBARS) in patients with colon cancer. Material and methods. Serum samples were obtained from 60 subjects (M and F, mean age 50±15 years), 30 of which were from colon cancer patients and 30 from healthy individuals. All the serum samples were analyzed for carcinoembryonic antigen (CEA), protein thiols and TBARS. Results. The levels of protein thiols were significantly lower in colon cancer patients (p<0.001) than in the healthy controls. The TBARS levels in colon cancer patients were moderately high (p<0.05) in comparison with those of the controls. Conclusions. Low levels of protein thiols and elevated TBARS of colon cancer patients support the hypothesis that colon cancer is associated with reactive oxygen species. Therefore protein thiols and TBARS may serve as additive non-invasive biochemical markers of oxidative stress in colon cancer and this hypothesis needs to be further investigated.",
author = "Nayak, {B. Shivananda} and Sneha Pinto",
year = "2007",
month = "6",
day = "15",
doi = "10.1080/00365520601137264",
language = "English",
volume = "42",
pages = "848--851",
journal = "Scandinavian Journal of Gastroenterology",
issn = "0036-5521",
publisher = "Informa Healthcare",
number = "7",

}

Protein thiols and thiobarbituric acid reactive substance status in colon cancer patients. / Nayak, B. Shivananda; Pinto, Sneha.

In: Scandinavian Journal of Gastroenterology, Vol. 42, No. 7, 15.06.2007, p. 848-851.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Protein thiols and thiobarbituric acid reactive substance status in colon cancer patients

AU - Nayak, B. Shivananda

AU - Pinto, Sneha

PY - 2007/6/15

Y1 - 2007/6/15

N2 - Objective. Colon cancer is the most common malignancy found in the developed countries. Cancer initiation and progression is known to be associated with the formation of reactive oxygen species, formed in excess in the gastrointestinal tract. The aim of the study was to assess the levels of protein thiols and thiobarbituric acid reactive substances (TBARS) in patients with colon cancer. Material and methods. Serum samples were obtained from 60 subjects (M and F, mean age 50±15 years), 30 of which were from colon cancer patients and 30 from healthy individuals. All the serum samples were analyzed for carcinoembryonic antigen (CEA), protein thiols and TBARS. Results. The levels of protein thiols were significantly lower in colon cancer patients (p<0.001) than in the healthy controls. The TBARS levels in colon cancer patients were moderately high (p<0.05) in comparison with those of the controls. Conclusions. Low levels of protein thiols and elevated TBARS of colon cancer patients support the hypothesis that colon cancer is associated with reactive oxygen species. Therefore protein thiols and TBARS may serve as additive non-invasive biochemical markers of oxidative stress in colon cancer and this hypothesis needs to be further investigated.

AB - Objective. Colon cancer is the most common malignancy found in the developed countries. Cancer initiation and progression is known to be associated with the formation of reactive oxygen species, formed in excess in the gastrointestinal tract. The aim of the study was to assess the levels of protein thiols and thiobarbituric acid reactive substances (TBARS) in patients with colon cancer. Material and methods. Serum samples were obtained from 60 subjects (M and F, mean age 50±15 years), 30 of which were from colon cancer patients and 30 from healthy individuals. All the serum samples were analyzed for carcinoembryonic antigen (CEA), protein thiols and TBARS. Results. The levels of protein thiols were significantly lower in colon cancer patients (p<0.001) than in the healthy controls. The TBARS levels in colon cancer patients were moderately high (p<0.05) in comparison with those of the controls. Conclusions. Low levels of protein thiols and elevated TBARS of colon cancer patients support the hypothesis that colon cancer is associated with reactive oxygen species. Therefore protein thiols and TBARS may serve as additive non-invasive biochemical markers of oxidative stress in colon cancer and this hypothesis needs to be further investigated.

UR - http://www.scopus.com/inward/record.url?scp=34250165391&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250165391&partnerID=8YFLogxK

U2 - 10.1080/00365520601137264

DO - 10.1080/00365520601137264

M3 - Article

C2 - 17558909

AN - SCOPUS:34250165391

VL - 42

SP - 848

EP - 851

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

SN - 0036-5521

IS - 7

ER -